In recent years clinical cancer genetics has become increasingly important. Several events, in particular the developments in DNA-based technology, have contributed to this evolution. Clinical cancer genetics has now matured to a medical discipline which is truly multidisciplinary in which clinical and molecular geneticists work together with clinical and medical oncologists as well as with psycho-social workers.Due to the multidisciplinary nature of clinical cancer genetics most papers are currently being published in a wide variety of journals on epidemiology, oncology and genetics. Familial Cancer provides a forum bringing these topics together focusing on the interests and needs of the clinician.The journal mainly concentrates on clinical cancer genetics. Most major areas in the field shall be included, such as epidemiology of familial cancer, molecular analysis and diagnosis, clinical expression, treatment and prevention, counselling and the health economics of familial cancer.
近年来，临床癌症遗传学变得越来越重要。几个事件，特别是基于DNA的技术的发展，促成了这一演变。临床癌症遗传学现在已经成熟为一门真正多学科的医学学科，其中临床和分子遗传学家与临床和医学肿瘤学家以及心理社会工作者一起工作。由于临床癌症遗传学的多学科性质，大多数论文目前发表在流行病学、肿瘤学和遗传学的各种杂志上。《家族癌症》提供了一个论坛，将这些主题集中在临床医生的兴趣和需求上。该杂志主要关注临床癌症遗传学。应包括该领域的大多数主要领域，如家族性癌症的流行病学、分子分析和诊断、临床表现、治疗和预防、咨询和家族性癌症的卫生经济学。
Hereditary gastric cancer: what’s new? Update 2013–2018
来源期刊：Familial CancerDOI：10.1007/s10689-019-00127-7
Moving into the mainstream: healthcare professionals’ views of implementing treatment focussed genetic testing in breast cancer care
来源期刊：Familial CancerDOI：10.1007/s10689-019-00122-y
Inequities in multi-gene hereditary cancer testing: lower diagnostic yield and higher VUS rate in individuals who identify as Hispanic, African or Asian and Pacific Islander as compared to European
来源期刊：Familial CancerDOI：10.1007/s10689-019-00144-6
Implication of DNA repair genes in Lynch-like syndrome
来源期刊：Familial CancerDOI：10.1007/s10689-019-00128-6
Novel candidates in early-onset familial colorectal cancer
来源期刊：Familial CancerDOI：10.1007/s10689-019-00145-5
Hereditary diffuse gastric cancer: cancer risk and the personal cost of preventive surgery
来源期刊：Familial CancerDOI：10.1007/s10689-019-00133-9
Ability of known susceptibility SNPs to predict colorectal cancer risk for persons with and without a family history
来源期刊：Familial CancerDOI：10.1007/s10689-019-00136-6
Long-term positive psychological outcomes in an Australian pancreatic cancer screening program
来源期刊：Familial CancerDOI：10.1007/s10689-019-00147-3
Should unaffected female BRCA2 pathogenic variant carriers be told there is little or no advantage from risk reducing mastectomy?
来源期刊：Familial CancerDOI：10.1007/s10689-019-00142-8
Renal cell carcinoma in young FH mutation carriers: case series and review of the literature
来源期刊：Familial CancerDOI：10.1007/s10689-019-00155-3
‘We don’t know for sure’: discussion of uncertainty concerning multigene panel testing during initial cancer genetic consultations
来源期刊：Familial CancerDOI：10.1007/s10689-019-00154-4
Genetic counseling referral for ovarian cancer patients: a call to action
来源期刊：Familial CancerDOI：10.1007/s10689-019-00129-5
Pediatric craniopharyngioma in association with familial adenomatous polyposis
来源期刊：Familial CancerDOI：10.1007/s10689-019-00126-8
The incidence of consecutive manifestations in Von Hippel-Lindau disease
来源期刊：Familial CancerDOI：10.1007/s10689-019-00131-x
Radiotherapy-induced malignancies in breast cancer patients with TP53 pathogenic germline variants (Li–Fraumeni syndrome)
来源期刊：Familial CancerDOI：10.1007/s10689-019-00153-5
TP53 variants of uncertain significance: increasing challenges in variant interpretation and genetic counseling
来源期刊：Familial CancerDOI：10.1007/s10689-019-00140-w
Health behaviours and beliefs in individuals with familial pancreatic cancer
来源期刊：Familial CancerDOI：10.1007/s10689-019-00143-7
Mutated SON putatively causes a cancer syndrome comprising high-risk medulloblastoma combined with café-au-lait spots
来源期刊：Familial CancerDOI：10.1007/s10689-019-00121-z
Phenotypic confirmation of oligodontia, colorectal polyposis and cancer in a family carrying an exon 7 nonsense variant in the AXIN2 gene
来源期刊：Familial CancerDOI：10.1007/s10689-019-00120-0
Implementation of a Systematic Tumor Screening Program for Lynch Syndrome in an Integrated Health Care Setting
来源期刊：Familial CancerDOI：10.1007/s10689-019-00123-x
Progress report: familial pancreatic cancer
来源期刊：Familial CancerDOI：10.1007/s10689-019-00125-9
Exploring the preferences of involved health professionals regarding the implementation of an online decision aid to support couples during reproductive decision-making in hereditary cancer: a mixed methods approach
来源期刊：Familial CancerDOI：10.1007/s10689-019-00119-7
Multiple primary malignancies associated with a germline SMARCB1 pathogenic variant
来源期刊：Familial CancerDOI：10.1007/s10689-019-00138-4
Energy balance related lifestyle factors and risk of endometrial and colorectal cancer among individuals with lynch syndrome: a systematic review
来源期刊：Familial CancerDOI：10.1007/s10689-019-00135-7
MLH1 promoter hypermethylation: are you absolutely sure about the absence of MLH1 germline mutation? About a new case
来源期刊：Familial CancerDOI：10.1007/s10689-019-00151-7
The (ir)relevance of the abandoned criterion II for the diagnosis of serrated polyposis syndrome: a retrospective cohort study
来源期刊：Familial CancerDOI：10.1007/s10689-019-00156-2
Population frequencies of pathogenic alleles of BRCA1 and BRCA2: analysis of 173 Danish breast cancer pedigrees using the BOADICEA model
来源期刊：Familial CancerDOI：10.1007/s10689-019-00141-9
Lynch syndrome with exclusive skin involvement: time to consider a molecular definition?
来源期刊：Familial CancerDOI：10.1007/s10689-019-00139-3
Targeted next generation sequencing screening of Lynch syndrome in Tunisian population
来源期刊：Familial CancerDOI：10.1007/s10689-019-00130-y
A unique case of two somatic APC mutations in an early onset cribriform-morular variant of papillary thyroid carcinoma and overview of the literature
来源期刊：Familial CancerDOI：10.1007/s10689-019-00146-4
International society for gastrointestinal hereditary tumours—InSiGHT
来源期刊：Familial CancerDOI：10.1007/s10689-019-00124-w
Assessing a single SNP located at TERT/CLPTM1L multi-cancer risk region as a genetic modifier for risk of pancreatic cancer and melanoma in Dutch CDKN2A mutation carriers
来源期刊：Familial CancerDOI：10.1007/s10689-019-00137-5
De novo pathogenic germline variant in PALB2 in a patient with pancreatic cancer
来源期刊：Familial CancerDOI：10.1007/s10689-019-00157-1
Clear cell chondrosarcoma in Von Hippel-Lindau disease
来源期刊：Familial CancerDOI：10.1007/s10689-019-00149-1
Endoscopic full thickness resection for early colon cancer in Lynch syndrome
来源期刊：Familial CancerDOI：10.1007/s10689-019-00132-w
