The European Journal of Pharmacology publishes research papers covering all aspects of experimental pharmacology with focus on the mechanism of action of structurally identified compounds affecting biological systems.The scope includes:Behavioural pharmacologyNeuropharmacology and analgesiaCardiovascular pharmacologyPulmonary, gastrointestinal and urogenital pharmacologyEndocrine pharmacologyImmunopharmacology and inflammationMolecular and cellular pharmacologyRegenerative pharmacologyBiologicals and biotherapeuticsTranslational pharmacologyNutriceutical pharmacology.
《欧洲药理学杂志》发表的研究论文涵盖了实验药理学的各个方面,重点是结构确定的化合物影响生物系统的作用机制,范围包括:行为药理学神经药理学和镇痛心血管药理学肺、胃肠和泌尿生殖药理学内分泌药理学免疫药理学和炎症分子和细胞药理学再生药理学生物制剂和生物治疗转化药理学营养药理学。
Sevoflurane inhibits the migration and invasion of colorectal cancer cells through regulating ERK/MMP‐9 pathway by up‐regulating miR‐203
来源期刊:European Journal of PharmacologyDOI:10.1016/j.ejphar.2019.01.025
Current overview on the clinical update of Bcl-2 anti-apoptotic inhibitors for cancer therapy.
来源期刊:European journal of pharmacologyDOI:10.1016/j.ejphar.2019.172655
Auranofin lethality to prostate cancer includes inhibition of proteasomal deubiquitinases and disrupted androgen receptor signaling
来源期刊:European Journal of PharmacologyDOI:10.1016/j.ejphar.2019.01.004
Old wine in new bottles: Drug repurposing in oncology.
来源期刊:European journal of pharmacologyDOI:10.1016/j.ejphar.2019.172784
Parecoxib, a selective blocker of cyclooxygenase‐2, directly inhibits neuronal delayed‐rectifier K+ current, M‐type K+ current and Na+ current
来源期刊:European Journal of PharmacologyDOI:10.1016/j.ejphar.2018.12.005
Klotho inhibits angiotensin II-induced cardiac hypertrophy, fibrosis, and dysfunction in mice through suppression of transforming growth factor-β1 signaling pathway.
来源期刊:European journal of pharmacologyDOI:10.1016/j.ejphar.2019.172549
Anticancer effect of pan‐PI3K inhibitor on multiple myeloma cells: Shedding new light on the mechanisms involved in BKM120 resistance
来源期刊:European Journal of PharmacologyDOI:10.1016/j.ejphar.2018.10.036
Empagliflozin restores lowered exercise endurance capacity via the activation of skeletal muscle fatty acid oxidation in a murine model of heart failure.
来源期刊:European journal of pharmacologyDOI:10.1016/j.ejphar.2019.172810
Puerarin inhibits vascular calcification of uremic rats.
来源期刊:European journal of pharmacologyDOI:10.1016/j.ejphar.2019.05.023
(-)-Myrtenol accelerates healing of acetic acid-induced gastric ulcers in rats and in human gastric adenocarcinoma cells.
来源期刊:European journal of pharmacologyDOI:10.1016/j.ejphar.2019.04.025
Glabridin resensitizes p‐glycoprotein‐overexpressing multidrug‐resistant cancer cells to conventional chemotherapeutic agents
来源期刊:European Journal of PharmacologyDOI:10.1016/j.ejphar.2019.04.002
Vitamin D protects against diabetic nephropathy: Evidence-based effectiveness and mechanism.
来源期刊:European journal of pharmacologyDOI:10.1016/j.ejphar.2018.09.037
In silico approaches for screening molecular targets in Candida albicans: A proteomic insight into drug discovery and development.
来源期刊:European journal of pharmacologyDOI:10.1016/j.ejphar.2018.10.016
Review of the anti-inflammatory effect of SIRT1 and SIRT2 modulators on neurodegenerative diseases.
来源期刊:European journal of pharmacologyDOI:10.1016/j.ejphar.2019.172847
Hematological malignancies and molecular targeting therapy.
来源期刊:European journal of pharmacologyDOI:10.1016/j.ejphar.2019.172641
Hydralazine protects against renal ischemia‐reperfusion injury in rats
来源期刊:European Journal of PharmacologyDOI:10.1016/j.ejphar.2018.11.015
Mast cell-mediated mechanistic pathways in organ transplantation.
来源期刊:European journal of pharmacologyDOI:10.1016/j.ejphar.2019.172458
EPA:DHA 6:1 is a superior omega‐3 PUFAs formulation attenuating platelets‐induced contractile responses in porcine coronary and human internal mammary artery by targeting the serotonin pathway via an increased endothelial formation of nitric oxide
来源期刊:European Journal of PharmacologyDOI:10.1016/j.ejphar.2019.03.022
Phellodendrine chloride suppresses proliferation of KRAS mutated pancreatic cancer cells through inhibition of nutrients uptake via macropinocytosis
来源期刊:European Journal of PharmacologyDOI:10.1016/j.ejphar.2019.01.060
Coiled‐coil domain‐containing 80 accelerates atherosclerosis development through decreasing lipoprotein lipase expression via ERK1/2 phosphorylation and TET2 expression
来源期刊:European Journal of PharmacologyDOI:10.1016/j.ejphar.2018.11.009
Noradrenaline reuptake inhibition increases control of impulsive action by activating D1‐like receptors in the infralimbic cortex
来源期刊:European Journal of PharmacologyDOI:10.1016/j.ejphar.2018.11.041
Mitochondrial E3 ubiquitin ligase 1 promotes brain injury by disturbing mitochondrial dynamics in a rat model of ischemic stroke.
来源期刊:European journal of pharmacologyDOI:10.1016/j.ejphar.2019.172617
Short chain fatty acid butyrate uptake reduces expressions of prostanoid EP4 receptors and their mediation of cyclooxygenase‐2 induction in HCA‐7 human colon cancer cells
来源期刊:European Journal of PharmacologyDOI:10.1016/j.ejphar.2019.04.014
Dysregulation of autophagy-related lncRNAs in peripheral blood of coronary artery disease patients.
来源期刊:European journal of pharmacologyDOI:10.1016/j.ejphar.2019.172852
iTRAQ‐based pharmacoproteomics reveals potential targets of berberine, a promising therapy for ulcerative colitis
来源期刊:European Journal of PharmacologyDOI:10.1016/j.ejphar.2019.02.021
Stearoyl lysophosphatidylcholine inhibits LPS‐induced extracellular release of HMGB1 through the G2A/calcium/CaMKK&bgr;/AMPK pathway
来源期刊:European Journal of PharmacologyDOI:10.1016/j.ejphar.2019.02.038
Increase of late sodium current contributes to enhanced susceptibility to atrial fibrillation in diabetic mice.
来源期刊:European journal of pharmacologyDOI:10.1016/j.ejphar.2019.172444
Pharmacology of Parsabiv® (etelcalcetide, ONO‐5163/AMG 416), a novel allosteric modulator of the calcium‐sensing receptor, for secondary hyperparathyroidism in hemodialysis patients
来源期刊:European Journal of PharmacologyDOI:10.1016/j.ejphar.2018.10.021
Bupivacaine‐induced contraction is attenuated by endothelial nitric oxide release modulated by activation of both stimulatory and inhibitory phosphorylation (Ser1177 and Thr495) of endothelial nitric oxide synthase
来源期刊:European Journal of PharmacologyDOI:10.1016/j.ejphar.2019.03.026
Suppressive effects of type I angiotensin receptor antagonists, candesartan and irbesartan on allergic asthma
来源期刊:European Journal of PharmacologyDOI:10.1016/j.ejphar.2019.02.035
The effects of dopamine D4 receptor ligands on operant alcohol self-administration and cue- and stress-induced reinstatement in rats.
来源期刊:European journal of pharmacologyDOI:10.1016/j.ejphar.2019.172838
Therapeutic effect and mechanism study of L-cysteine derivative 5P39 on LPS-induced acute lung injury in mice.
来源期刊:European journal of pharmacologyDOI:10.1016/j.ejphar.2019.172893
Naringenin attenuates carotid restenosis in rats after balloon injury through its anti-inflammation and anti-oxidative effects via the RIP1-RIP3-MLKL signaling pathway.
来源期刊:European journal of pharmacologyDOI:10.1016/j.ejphar.2019.05.012
Cardioprotective effects of galectin-3 inhibition against ischemia/reperfusion injury.
来源期刊:European journal of pharmacologyDOI:10.1016/j.ejphar.2019.172701
TsNTxP, a non-toxic protein from Tityus serrulatus scorpion venom, induces antinociceptive effects by suppressing glutamate release in mice.
来源期刊:European journal of pharmacologyDOI:10.1016/j.ejphar.2019.05.002
Simvastatin inhibits the proliferation of HL-60 clone 15- derived eosinophils by inducing the arrest of the cell cycle in the G1/S phase.
来源期刊:European journal of pharmacologyDOI:10.1016/j.ejphar.2019.05.029
Cytotoxicity of curcumin derivatives in ALK positive non-small cell lung cancer.
来源期刊:European journal of pharmacologyDOI:10.1016/j.ejphar.2019.172749
Delta‐opioid receptor antagonist naltrindole reduces oxycodone addiction and constipation in mice
来源期刊:European Journal of PharmacologyDOI:10.1016/j.ejphar.2019.04.009
Formoterol counteracts the inhibitory effect of cigarette smoke on glucocorticoid‐induced leucine zipper (GILZ) transactivation in human bronchial smooth muscle cells
来源期刊:European Journal of PharmacologyDOI:10.1016/j.ejphar.2019.02.010
p38 mitogen activated protein kinase mediates cardiac Na+/H+ exchanger inhibition induced by Sildenafil
来源期刊:European Journal of PharmacologyDOI:10.1016/j.ejphar.2019.01.070
Comparison of the effects of synthetic and plant-derived mTOR regulators on healthy human ovarian cells.
来源期刊:European journal of pharmacologyDOI:10.1016/j.ejphar.2019.03.048
DITMD‐induced mitotic defects and apoptosis in tumor cells by blocking the polo‐box domain‐dependent functions of polo‐like kinase 1
来源期刊:European Journal of PharmacologyDOI:10.1016/j.ejphar.2019.01.032
What is the impact of eukaryotic elongation factor 2 kinase on cancer: A systematic review.
来源期刊:European journal of pharmacologyDOI:10.1016/j.ejphar.2019.172470
Antidiabetic effects and sustained metabolic benefits of sub-chronic co-administration of exendin-4/gastrin and xenin-8-Gln in high fat fed mice.
来源期刊:European journal of pharmacologyDOI:10.1016/j.ejphar.2019.172733
Visfatin promotes the malignancy of human acute myeloid leukemia cells via regulation of IL‐17
来源期刊:European Journal of PharmacologyDOI:10.1016/j.ejphar.2019.03.016
Leukotriene B4 induces proliferation of rat pulmonary arterial smooth muscle cells via modulating GSK-3β/β-catenin pathway.
来源期刊:European journal of pharmacologyDOI:10.1016/j.ejphar.2019.172823
Cardioprotection of hydralazine against myocardial ischemia/reperfusion injury in rats.
来源期刊:European journal of pharmacologyDOI:10.1016/j.ejphar.2019.172850
Exogenous obestatin decreases beta‐cell apoptosis and alfa‐cell proliferation in high fat diet and streptozotocin induced type 2 diabetic rats
来源期刊:European Journal of PharmacologyDOI:10.1016/j.ejphar.2019.02.028
Enantiomer of the novel flexible heteroarotinoid, SL-1-09, blocks cell cycle progression in breast cancer cells.
来源期刊:European journal of pharmacologyDOI:10.1016/j.ejphar.2019.172634
Nitric oxide: Is it the culprit for the continued expansion of keloids?
来源期刊:European journal of pharmacologyDOI:10.1016/j.ejphar.2019.04.040