The AAPS Journal, an official journal of the American Association of Pharmaceutical Scientists (AAPS), publishes novel and significant findings in the various areas of pharmaceutical sciences impacting human and veterinary therapeutics, including:· Drug Design and Discovery· Pharmaceutical Biotechnology· Biopharmaceutics, Formulation, and Drug Delivery· Metabolism and Transport· Pharmacokinetics, Pharmacodynamics, and Pharmacometrics· Translational Research· Clinical Evaluations and Therapeutic Outcomes· Regulatory ScienceWe invite submissions under the following article types:· Original Research Articles· Reviews and Mini-reviews· White Papers, Commentaries, and Editorials· Meeting Reports· Brief/Technical Reports and Rapid Communications· Regulatory Notes· Tutorials· Protocols in the Pharmaceutical SciencesIn addition, The AAPS Journal publishes themes, organized by guest editors, which are focused on particular areas of current interest to our field.
AAPS期刊是美国药学科学家协会（AAPS）的官方期刊，发表影响人类和兽医治疗的药学科学各个领域的新颖和重要发现，包括：·药物设计和发现·药物生物技术·生物药剂学、制剂和药物递送·代谢和转运·药代动力学、药效学和药理学·转化研究·临床评价和治疗结果·监管科学我们邀请以下文章类型的投稿：·原创研究文章·综述和小型综述·白色、评论和社论·会议报告·简报/技术报告和快速交流·监管说明·教程·药学科学方案此外，AAPS期刊还发布由客座编辑组织的主题，这些主题集中在我们领域当前感兴趣的特定领域。
Dissolution and Translational Modeling Strategies Toward Establishing an In Vitro-In Vivo Link—a Workshop Summary Report
来源期刊：The AAPS JournalDOI：10.1208/s12248-019-0298-x
Report of the AAPS Guidance Forum on the FDA Draft Guidance for Industry: “Drug Products, Including Biological Products, that Contain Nanomaterials”
来源期刊：The AAPS JournalDOI：10.1208/s12248-019-0329-7
A Computational Model of Neoadjuvant PD-1 Inhibition in Non-Small Cell Lung Cancer
来源期刊：The AAPS JournalDOI：10.1208/s12248-019-0350-x
PBPK Absorption Modeling: Establishing the In Vitro–In Vivo Link—Industry Perspective
来源期刊：The AAPS JournalDOI：10.1208/s12248-019-0292-3
Translational Quantitative Systems Pharmacology in Drug Development: from Current Landscape to Good Practices
来源期刊：The AAPS JournalDOI：10.1208/s12248-019-0339-5
In Vitro and In Vivo Co-delivery of siRNA and Doxorubicin by Folate-PEG-Appended Dendrimer/Glucuronylglucosyl-β-Cyclodextrin Conjugate
来源期刊：The AAPS JournalDOI：10.1208/s12248-019-0327-9
Fit-for-Purpose Quality Control System in Continuous Bioanalysis During Long-Term Pediatric Studies
来源期刊：The AAPS JournalDOI：10.1208/s12248-019-0375-1
Incurred Sample Reanalysis: Time to Change the Sample Size Calculation?
来源期刊：The AAPS JournalDOI：10.1208/s12248-019-0293-2
Application of Mechanistic Ocular Absorption Modeling and Simulation to Understand the Impact of Formulation Properties on Ophthalmic Bioavailability in Rabbits: a Case Study Using Dexamethasone Suspension
来源期刊：The AAPS JournalDOI：10.1208/s12248-019-0334-x
Compensated Hydroxyl Radical Protein Footprinting Measures Buffer and Excipient Effects on Conformation and Aggregation in an Adalimumab Biosimilar
来源期刊：The AAPS JournalDOI：10.1208/s12248-019-0358-2
Nanomaterial-Based Modulation of Tumor Microenvironments for Enhancing Chemo/Immunotherapy
来源期刊：The AAPS JournalDOI：10.1208/s12248-019-0333-y
Anthocyanin Delphinidin Prevents Neoplastic Transformation of Mouse Skin JB6 P+ Cells: Epigenetic Re-activation of Nrf2-ARE Pathway
来源期刊：The AAPS JournalDOI：10.1208/s12248-019-0355-5
“Development of Fixed Dose Combination Products” Workshop Report: Considerations of Gastrointestinal Physiology and Overall Development Strategy
来源期刊：The AAPS JournalDOI：10.1208/s12248-019-0346-6
Estimation of Solid Tumor Doubling Times from Progression-Free Survival Plots Using a Novel Statistical Approach
来源期刊：The AAPS JournalDOI：10.1208/s12248-019-0302-5
A Systems Pharmacology Model for Drug Delivery to Solid Tumors by Antibody-Drug Conjugates: Implications for Bystander Effects
来源期刊：The AAPS JournalDOI：10.1208/s12248-019-0390-2
Theoretical Considerations for Direct Translation of Unbound Liver-to-Plasma Partition Coefficient from In Vitro to In Vivo
来源期刊：The AAPS JournalDOI：10.1208/s12248-019-0314-1
Evaluating a Multiscale Mechanistic Model of the Immune System to Predict Human Immunogenicity for a Biotherapeutic in Phase 1
来源期刊：The AAPS JournalDOI：10.1208/s12248-019-0361-7
Mind the Gaps: Ontogeny of Human Brain P-gp and Its Impact on Drug Toxicity
来源期刊：The AAPS JournalDOI：10.1208/s12248-019-0340-z
Quality Controls in Ligand Binding Assays: Recommendations and Best Practices for Preparation, Qualification, Maintenance of Lot to Lot Consistency, and Prevention of Assay Drift
来源期刊：The AAPS JournalDOI：10.1208/s12248-019-0354-6
On the Comparison of Methods in Analyzing Bounded Outcome Score Data
来源期刊：The AAPS JournalDOI：10.1208/s12248-019-0370-6
Scaling Drug Clearance from Adults to the Young Children for Drugs Undergoing Hepatic Metabolism: A Simulation Study to Search for the Simplest Scaling Method
来源期刊：The AAPS JournalDOI：10.1208/s12248-019-0295-0
TCPro: an In Silico Risk Assessment Tool for Biotherapeutic Protein Immunogenicity
来源期刊：The AAPS JournalDOI：10.1208/s12248-019-0368-0
Biotransformation of the New Synthetic Cannabinoid with an Alkene, MDMB-4en-PINACA, by Human Hepatocytes, Human Liver Microsomes, and Human Urine and Blood
来源期刊：The AAPS JournalDOI：10.1208/s12248-019-0381-3
Reengineering of Albumin-Fused Cocaine Hydrolase CocH1 (TV-1380) to Prolong Its Biological Half-Life
来源期刊：The AAPS JournalDOI：10.1208/s12248-019-0377-z
CAR T Cell Immunotherapy in Human and Veterinary Oncology: Changing the Odds Against Hematological Malignancies
来源期刊：The AAPS JournalDOI：10.1208/s12248-019-0322-1
A Fit-for-Purpose Method for the Detection of Human Antibodies to Surface-Exposed Components of BMS-986263, a Lipid Nanoparticle-Based Drug Product Containing a siRNA Drug Substance
来源期刊：The AAPS JournalDOI：10.1208/s12248-019-0360-8
Fetal Concentrations of Budesonide and Fluticasone Propionate: a Study in Mice
来源期刊：The AAPS JournalDOI：10.1208/s12248-019-0313-2
Neutralizing Antibody Assay Development with High Drug and Target Tolerance to Support Clinical Development of an Anti-TFPI Therapeutic Monoclonal Antibody
来源期刊：The AAPS JournalDOI：10.1208/s12248-019-0320-3
In Vitro Metabolism and Hepatic Intrinsic Clearance of the Synthetic Cannabinoid Receptor Agonist JWH-122 and Its Four ω-Halogenated Analogues
来源期刊：The AAPS JournalDOI：10.1208/s12248-019-0338-6
Population Pharmacokinetics and Pharmacodynamics of Apixaban Linking Its Plasma Concentration to Intrinsic Activated Coagulation Factor X Activity in Japanese Patients with Atrial Fibrillation
来源期刊：The AAPS JournalDOI：10.1208/s12248-019-0353-7
Modeling Combined Anti-Inflammatory Effects of Dexamethasone and Tofacitinib in Arthritic Rats
来源期刊：The AAPS JournalDOI：10.1208/s12248-019-0362-6
Deconvolution Analysis by Non-linear Regression Using a Convolution-Based Model: Comparison of Nonparametric and Parametric Approaches
来源期刊：The AAPS JournalDOI：10.1208/s12248-019-0389-8
Anti-drug Antibody Assay Validation: Improved Reporting of the Assay Selectivity via Simpler Positive Control Recovery Data Analysis
来源期刊：The AAPS JournalDOI：10.1208/s12248-019-0347-5
Phase-Appropriate Application of Analytical Methods to Monitor Subvisible Particles Across the Biotherapeutic Drug Product Life Cycle
来源期刊：The AAPS JournalDOI：10.1208/s12248-019-0384-0
Mechanistic Deconvolution of Oral Absorption Model with Dynamic Gastrointestinal Fluid to Predict Regional Rate and Extent of GI Drug Dissolution
来源期刊：The AAPS JournalDOI：10.1208/s12248-019-0385-z
Quantitative Prediction of Human Hepatic Clearance for P450 and Non-P450 Substrates from In Vivo Monkey Pharmacokinetics Study and In Vitro Metabolic Stability Tests Using Hepatocytes
来源期刊：The AAPS JournalDOI：10.1208/s12248-019-0294-1
Model-Based Conditional Weighted Residuals Analysis for Structural Model Assessment
来源期刊：The AAPS JournalDOI：10.1208/s12248-019-0305-2
Estimating In Vivo Fractional Contribution of OATP1B1 to Human Hepatic Active Uptake by Mechanistically Modeling Pharmacogenetic Data
来源期刊：The AAPS JournalDOI：10.1208/s12248-019-0337-7
Simulating the Impact of Elevated Levels of Interleukin-6 on the Pharmacokinetics of Various CYP450 Substrates in Patients with Neuromyelitis Optica or Neuromyelitis Optica Spectrum Disorders in Different Ethnic Populations
来源期刊：The AAPS JournalDOI：10.1208/s12248-019-0309-y
Inhibition of Hepatic CYP2D6 by the Active N-Oxide Metabolite of Sorafenib
来源期刊：The AAPS JournalDOI：10.1208/s12248-019-0374-2
Current Perspectives on Ligand-Binding Assay Practices in the Quantification of Circulating Therapeutic Proteins for Biosimilar Biological Product Development
来源期刊：The AAPS JournalDOI：10.1208/s12248-019-0397-8
Multiplexed Gene Expression as a Characterization of Bioactivity for Interferon Beta (IFN-β) Biosimilar Candidates: Impact of Innate Immune Response Modulating Impurities (IIRMIs)
来源期刊：The AAPS JournalDOI：10.1208/s12248-019-0300-7
Dissolution Chamber for Small Drug Delivery System in the Periodontal Pocket
来源期刊：The AAPS JournalDOI：10.1208/s12248-019-0317-y
Correction to: A Translational Quantitative Systems Pharmacology Model for CD3 Bispecific Molecules: Application to Quantify T Cell-Mediated Tumor Cell Killing by P-Cadherin LP DART®
来源期刊：The AAPS JournalDOI：10.1208/s12248-019-0348-4
Variability Attribution for Automated Model Building
来源期刊：The AAPS JournalDOI：10.1208/s12248-019-0310-5
Systemic Bioequivalence Is Unlikely to Equal Target Site Bioequivalence for Nanotechnology Oncologic Products
来源期刊：The AAPS JournalDOI：10.1208/s12248-019-0296-z
A Novel Method for Analysing Frequent Observations from Questionnaires in Order to Model Patient-Reported Outcomes: Application to EXACT® Daily Diary Data from COPD Patients
来源期刊：The AAPS JournalDOI：10.1208/s12248-019-0319-9
Population Pharmacokinetic Modeling in the Presence of Missing Time-Dependent Covariates: Impact of Body Weight on Pharmacokinetics of Paracetamol in Neonates
来源期刊：The AAPS JournalDOI：10.1208/s12248-019-0331-0
Analysis of the Regulatory Divergence of Comparative Dissolution Requirements for Post-Approval Manufacturing Changes of Modified Release Solid Oral Dosage Forms
来源期刊：The AAPS JournalDOI：10.1208/s12248-019-0383-1
Induction and Impact of Anti-Drug Responses Elicited by a Human Recombinant Coagulation Factor FXaI16L in Preclinical Species
来源期刊：The AAPS JournalDOI：10.1208/s12248-019-0324-z
