The European Journal of Medicinal Chemistry is a global journal that publishes studies on all aspects of medicinal chemistry. It provides a medium for publication of original papers and also welcomes critical review papers. A typical paper would report on the organic synthesis, characterization and pharmacological evaluation of compounds. Other topics of interest are drug design, QSAR, molecular modeling, drug-receptor interactions, molecular aspects of drug metabolism, prodrug synthesis and drug targeting. The journal expects manuscripts to present the rational for a study, provide insight into the design of compounds or understanding of mechanism, or clarify the targets.
《欧洲药物化学杂志》是一份全球性杂志，发表药物化学各个方面的研究。它提供了发表原创论文的媒介，也欢迎评论性论文，典型的论文将报告化合物的有机合成、表征和药理学评价。其他感兴趣的主题是药物设计、QSAR、分子建模、药物-受体相互作用、药物代谢的分子方面、前药合成和药物靶向。该杂志希望稿件能提出研究的理由，提供化合物设计的见解或机制的理解，或阐明目标。
Applications of fluorine-containing amino acids for drug design.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.111826
Synthetic approaches and pharmaceutical applications of chloro-containing molecules for drug discovery: A critical review
来源期刊：European Journal of Medicinal ChemistryDOI：10.1016/j.ejmech.2019.03.063
Histone deacetylase 8 (HDAC8) and its inhibitors with selectivity to other isoforms: An overview.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2018.12.039
Developments in the anticancer activity of structurally modified curcumin: An up-to-date review.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.04.058
Multi-target compounds acting in cancer progression: Focus on thiosemicarbazone, thiazole and thiazolidinone analogues.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.03.024
Phosphatidylinositol 3 kinase (PI3K) inhibitors as new weapon to combat cancer.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.111718
Design, synthesis and biological evaluation of quinoline-indole derivatives as anti-tubulin agents targeting the colchicine binding site.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2018.11.070
Thiazole, thio and semicarbazone derivatives against tropical infective diseases: Chagas disease, human African trypanosomiasis (HAT), leishmaniasis, and malaria.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2018.11.013
Recent advances in the development of neuroprotective agents and therapeutic targets in the treatment of cerebral ischemia.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2018.11.014
Discovery of novel functionalized 1,2,4-triazoles as PARP-1 inhibitors in breast cancer: Design, synthesis and antitumor activity evaluation.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.111621
Discovery of novel pyrimidine-based benzothiazole derivatives as potent cyclin-dependent kinase 2 inhibitors with anticancer activity.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.06.055
Design and synthesis of novel xanthone-triazole derivatives as potential antidiabetic agents: α-Glucosidase inhibition and glucose uptake promotion.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.05.045
Modulation of the spacer in N,N-bis(alkanol)amine aryl ester heterodimers led to the discovery of a series of highly potent P-glycoprotein-based multidrug resistance (MDR) modulators.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.03.054
Revealing quinquennial anticancer journey of morpholine: A SAR based review.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.02.015
Curcumin as tyrosine kinase inhibitor in cancer treatment.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.07.015
A class of novel tubulin polymerization inhibitors exert effective anti-tumor activity via mitotic catastrophe.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2018.12.030
Synthesis and biological evaluation of coumarin derivatives as α-glucosidase inhibitors.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.112013
β-Carboline and N-hydroxycinnamamide hybrids as anticancer agents for drug-resistant hepatocellular carcinoma.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.02.054
Design, synthesis and evaluation of pentacycloundecane and hexacycloundecane propargylamine derivatives as multifunctional neuroprotective agents.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2018.11.051
Anticancer activity, dual prooxidant/antioxidant effect and apoptosis induction profile of new bichalcophene-5-carboxamidines.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.02.062
Design and synthesis of (2-(phenylamino)thieno[3,2-d]pyrimidin-4-yl)(3,4,5-trimethoxyphenyl)methanone analogues as potent anti-tubulin polymerization agents.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.111679
Discovery of a potent histone deacetylase (HDAC) 3/6 selective dual inhibitor.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.111755
Novel prenyloxy chalcones as potential leishmanicidal and trypanocidal agents: Design, synthesis and evaluation.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.02.028
Novel benzenesulfonamide and 1,2-benzisothiazol-3(2H)-one-1,1-dioxide derivatives as potential selective COX-2 inhibitors.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.03.042
Discovery of phosphonamidate IDO1 inhibitors for the treatment of non-small cell lung cancer.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.111629
Pyranocarbazole derivatives as potent anti-cancer agents triggering tubulin polymerization stabilization induced activation of caspase-dependent apoptosis and downregulation of Akt/mTOR in breast cancer cells.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.02.003
N-thiadiazole-4-hydroxy-2-quinolone-3-carboxamides bearing heteroaromatic rings as novel antibacterial agents: Design, synthesis, biological evaluation and target identification.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.112022
Lipophilic efficient phenylthiazoles with potent undecaprenyl pyrophosphatase inhibitory activity.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.04.063
Targeting tropomyosin receptor kinase for cancer therapy.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.04.053
Identification of benzo[cd]indol-2(1H)-ones as novel Atg4B inhibitors via a structure-based virtual screening and a novel AlphaScreen assay.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.05.086
Pyrrolo and pyrrolopyrimidine sulfonamides act as cytotoxic agents in hypoxia via inhibition of transmembrane carbonic anhydrases.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.112021
Discovery, synthesis and anti-atherosclerotic activities of a novel selective sphingomyelin synthase 2 inhibitor.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2018.12.028
Design and synthesis of parthenolide and 5-fluorouracil conjugates as potential anticancer agents against drug resistant hepatocellular carcinoma.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.111706
2-Aminoimidazole-based antagonists of the 5-HT6 receptor - A new concept in aminergic GPCR ligand design.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.06.001
Synthesis and evaluation of 2-carboxy indole derivatives as potent and selective anti-leukemic agents.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.111570
Design, synthesis, and biological evaluation of 1-substituted -2-aryl imidazoles targeting tubulin polymerization as potential anticancer agents.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.111732
Synthesis and anti-cancer evaluation of folic acid-peptide- paclitaxel conjugates for addressing drug resistance.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.03.031
Benzo[b]thiophene-thiazoles as potent anti-Toxoplasma gondii agents: Design, synthesis, tyrosinase/tyrosine hydroxylase inhibitors, molecular docking study, and antioxidant activity.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.111765
Design, synthesis and pharmacological evaluation of a novel mTOR-targeted anti-EV71 agent.
来源期刊：European journal of medicinal chemistryDOI：10.1016/J.EJMECH.2019.04.048
Structural development of a type-1 ryanodine receptor (RyR1) Ca2+-release channel inhibitor guided by endoplasmic reticulum Ca2+ assay.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.06.076
Development of CXCR4 modulators based on the lead compound RB-108.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.03.065
An update about the crucial role of stereochemistry on the effects of Peroxisome Proliferator-Activated Receptor ligands.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.05.012
First-in-class allosteric inhibitors of bacterial IMPDHs.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.01.064
Jietacins, azoxy natural products, as novel NF-κB inhibitors: Discovery, synthesis, biological activity, and mode of action.
来源期刊：European journal of medicinal chemistryDOI：10.1016/J.EJMECH.2019.05.079
Discovery and structure-activity relationship of novel diphenylthiazole derivatives as BTK inhibitor with potent activity against B cell lymphoma cell lines.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.06.035
Design of fluorinated cyclopropane derivatives of 2-phenylcyclopropylmethylamine leading to identification of a selective serotonin 2C (5-HT2C) receptor agonist without 5-HT2B agonism.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.111626
Combating fluconazole-resistant fungi with novel β-azole-phenylacetone derivatives.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.111689
A concise review of recent advances in anti-heart failure targets and its small molecules inhibitors in recent years.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.111852
Discovery of 2-aminopyridines bearing a pyridone moiety as potent ALK inhibitors to overcome the crizotinib-resistant mutants.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.111734
Design, synthesis and biological evaluation of novel 5-(piperazin-1-yl)quinolin-2(1H)-one derivatives as potential chitin synthase inhibitors and antifungal agents.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.07.035
