The European Journal of Medicinal Chemistry is a global journal that publishes studies on all aspects of medicinal chemistry. It provides a medium for publication of original papers and also welcomes critical review papers.A typical paper would report on the organic synthesis, characterization and pharmacological evaluation of compounds. Other topics of interest are drug design, QSAR, molecular modeling, drug-receptor interactions, molecular aspects of drug metabolism, prodrug synthesis and drug targeting. The journal expects manuscripts to present the rational for a study, provide insight into the design of compounds or understanding of mechanism, or clarify the targets.
《欧洲药物化学杂志》是一份全球性杂志，发表药物化学各个方面的研究。它提供了发表原创论文的媒介，也欢迎评论性论文，典型的论文将报告化合物的有机合成、表征和药理学评价。其他感兴趣的主题是药物设计、QSAR、分子建模、药物-受体相互作用、药物代谢的分子方面、前药合成和药物靶向。该杂志希望稿件能提出研究的理由，提供化合物设计的见解或机制的理解，或阐明目标。
Applications of fluorine-containing amino acids for drug design.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.111826
Synthetic approaches and pharmaceutical applications of chloro-containing molecules for drug discovery: A critical review
来源期刊：European Journal of Medicinal ChemistryDOI：10.1016/j.ejmech.2019.03.063
Histone deacetylase 8 (HDAC8) and its inhibitors with selectivity to other isoforms: An overview.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2018.12.039
Developments in the anticancer activity of structurally modified curcumin: An up-to-date review.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.04.058
Multi-target compounds acting in cancer progression: Focus on thiosemicarbazone, thiazole and thiazolidinone analogues.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.03.024
Phosphatidylinositol 3 kinase (PI3K) inhibitors as new weapon to combat cancer.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.111718
Design, synthesis and biological evaluation of quinoline-indole derivatives as anti-tubulin agents targeting the colchicine binding site.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2018.11.070
Thiazole, thio and semicarbazone derivatives against tropical infective diseases: Chagas disease, human African trypanosomiasis (HAT), leishmaniasis, and malaria.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2018.11.013
Recent advances in the development of neuroprotective agents and therapeutic targets in the treatment of cerebral ischemia.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2018.11.014
Discovery of novel functionalized 1,2,4-triazoles as PARP-1 inhibitors in breast cancer: Design, synthesis and antitumor activity evaluation.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.111621
Discovery of novel pyrimidine-based benzothiazole derivatives as potent cyclin-dependent kinase 2 inhibitors with anticancer activity.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.06.055
Design and synthesis of novel xanthone-triazole derivatives as potential antidiabetic agents: α-Glucosidase inhibition and glucose uptake promotion.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.05.045
Modulation of the spacer in N,N-bis(alkanol)amine aryl ester heterodimers led to the discovery of a series of highly potent P-glycoprotein-based multidrug resistance (MDR) modulators.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.03.054
Revealing quinquennial anticancer journey of morpholine: A SAR based review.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.02.015
Curcumin as tyrosine kinase inhibitor in cancer treatment.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.07.015
A class of novel tubulin polymerization inhibitors exert effective anti-tumor activity via mitotic catastrophe.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2018.12.030
Synthesis and biological evaluation of coumarin derivatives as α-glucosidase inhibitors.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.112013
β-Carboline and N-hydroxycinnamamide hybrids as anticancer agents for drug-resistant hepatocellular carcinoma.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.02.054
Design, synthesis and evaluation of pentacycloundecane and hexacycloundecane propargylamine derivatives as multifunctional neuroprotective agents.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2018.11.051
Anticancer activity, dual prooxidant/antioxidant effect and apoptosis induction profile of new bichalcophene-5-carboxamidines.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.02.062
Design and synthesis of (2-(phenylamino)thieno[3,2-d]pyrimidin-4-yl)(3,4,5-trimethoxyphenyl)methanone analogues as potent anti-tubulin polymerization agents.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.111679
Discovery of a potent histone deacetylase (HDAC) 3/6 selective dual inhibitor.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.111755
Novel prenyloxy chalcones as potential leishmanicidal and trypanocidal agents: Design, synthesis and evaluation.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.02.028
Novel benzenesulfonamide and 1,2-benzisothiazol-3(2H)-one-1,1-dioxide derivatives as potential selective COX-2 inhibitors.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.03.042
Discovery of phosphonamidate IDO1 inhibitors for the treatment of non-small cell lung cancer.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.111629
Pyranocarbazole derivatives as potent anti-cancer agents triggering tubulin polymerization stabilization induced activation of caspase-dependent apoptosis and downregulation of Akt/mTOR in breast cancer cells.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.02.003
N-thiadiazole-4-hydroxy-2-quinolone-3-carboxamides bearing heteroaromatic rings as novel antibacterial agents: Design, synthesis, biological evaluation and target identification.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.112022
Lipophilic efficient phenylthiazoles with potent undecaprenyl pyrophosphatase inhibitory activity.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.04.063
Targeting tropomyosin receptor kinase for cancer therapy.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.04.053
Identification of benzo[cd]indol-2(1H)-ones as novel Atg4B inhibitors via a structure-based virtual screening and a novel AlphaScreen assay.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.05.086
Pyrrolo and pyrrolopyrimidine sulfonamides act as cytotoxic agents in hypoxia via inhibition of transmembrane carbonic anhydrases.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.112021
Discovery, synthesis and anti-atherosclerotic activities of a novel selective sphingomyelin synthase 2 inhibitor.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2018.12.028
Design and synthesis of parthenolide and 5-fluorouracil conjugates as potential anticancer agents against drug resistant hepatocellular carcinoma.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.111706
2-Aminoimidazole-based antagonists of the 5-HT6 receptor - A new concept in aminergic GPCR ligand design.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.06.001
Synthesis and evaluation of 2-carboxy indole derivatives as potent and selective anti-leukemic agents.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.111570
Design, synthesis, and biological evaluation of 1-substituted -2-aryl imidazoles targeting tubulin polymerization as potential anticancer agents.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.111732
Synthesis and anti-cancer evaluation of folic acid-peptide- paclitaxel conjugates for addressing drug resistance.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.03.031
Benzo[b]thiophene-thiazoles as potent anti-Toxoplasma gondii agents: Design, synthesis, tyrosinase/tyrosine hydroxylase inhibitors, molecular docking study, and antioxidant activity.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.111765
Design, synthesis and pharmacological evaluation of a novel mTOR-targeted anti-EV71 agent.
来源期刊：European journal of medicinal chemistryDOI：10.1016/J.EJMECH.2019.04.048
Structural development of a type-1 ryanodine receptor (RyR1) Ca2+-release channel inhibitor guided by endoplasmic reticulum Ca2+ assay.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.06.076
Development of CXCR4 modulators based on the lead compound RB-108.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.03.065
An update about the crucial role of stereochemistry on the effects of Peroxisome Proliferator-Activated Receptor ligands.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.05.012
First-in-class allosteric inhibitors of bacterial IMPDHs.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.01.064
Jietacins, azoxy natural products, as novel NF-κB inhibitors: Discovery, synthesis, biological activity, and mode of action.
来源期刊：European journal of medicinal chemistryDOI：10.1016/J.EJMECH.2019.05.079
Discovery and structure-activity relationship of novel diphenylthiazole derivatives as BTK inhibitor with potent activity against B cell lymphoma cell lines.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.06.035
Design of fluorinated cyclopropane derivatives of 2-phenylcyclopropylmethylamine leading to identification of a selective serotonin 2C (5-HT2C) receptor agonist without 5-HT2B agonism.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.111626
Combating fluconazole-resistant fungi with novel β-azole-phenylacetone derivatives.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.111689
A concise review of recent advances in anti-heart failure targets and its small molecules inhibitors in recent years.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.111852
Discovery of 2-aminopyridines bearing a pyridone moiety as potent ALK inhibitors to overcome the crizotinib-resistant mutants.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.111734
Design, synthesis and biological evaluation of novel 5-(piperazin-1-yl)quinolin-2(1H)-one derivatives as potential chitin synthase inhibitors and antifungal agents.
来源期刊：European journal of medicinal chemistryDOI：10.1016/j.ejmech.2019.07.035
