The aim of the Journal is to provide a forum for the critical analysis of advanced drug and gene delivery systems and their applications in human and veterinary medicine. The Journal has a broad scope, covering the key issues for effective drug and gene delivery, from administration to site-specific delivery.In general, the Journal publishes review articles in a Theme Issue format. Each Theme Issue provides a comprehensive and critical examination of current and emerging research on the design and development of advanced drug and gene delivery systems and their application to experimental and clinical therapeutics. The goal is to illustrate the pivotal role of a multidisciplinary approach to modern drug delivery, encompassing the application of sound biological and physicochemical principles to the engineering of drug delivery systems to meet the therapeutic need at hand. Importantly the Editorial Team of ADDR asks that the authors effectively window the extensive volume of literature, pick the important contributions and explain their importance, produce a forward looking identification of the challenges facing the field and produce a Conclusions section with expert recommendations to address the issues.Articles review the current status of a specific topic, giving equal emphasis to the identification of major conceptual and technological challenges to successful drug and gene delivery, to an evaluation of triumphs as well as shortcomings in current conceptual and technical approaches, and to a discussion of their possible solution.
该杂志的目的是为先进的药物和基因传递系统及其在人类和兽医学中的应用提供一个批判性分析的论坛。该杂志内容广泛，涵盖了有效药物和基因递送的关键问题，从给药到特定位点递送。一般而言，该杂志以主题期刊的形式发表综述文章。每一期主题期刊都对当前和新兴的先进药物和基因递送系统的设计和开发及其在实验和临床治疗中的应用进行了全面和批判性的审查。目的是阐明多学科方法在现代药物输送中的关键作用，包括合理的生物学和物理化学原理在药物输送系统工程中的应用，以满足当前的治疗需求。重要的是，ADDR的编辑团队要求作者有效地打开大量文献的窗口，挑选重要的贡献并解释它们的重要性，对该领域面临的挑战进行前瞻性的识别，并产生一个结论部分，其中包含专家建议来解决问题。文章回顾了特定主题的当前状态，同样重视确定成功的药物和基因递送所面临的主要概念和技术挑战，评价当前概念和技术方法的成功和不足，并讨论其可能的解决办法。
Concepts of nanoparticle cellular uptake, intracellular trafficking, and kinetics in nanomedicine.
来源期刊：Advanced drug delivery reviewsDOI：10.1016/j.addr.2019.04.008
Imaging and therapeutic applications of persistent luminescence nanomaterials
来源期刊：Advanced Drug Delivery ReviewsDOI：10.1016/j.addr.2018.10.015
Effect of physicochemical and surface properties on in vivo fate of drug nanocarriers.
来源期刊：Advanced drug delivery reviewsDOI：10.1016/j.addr.2019.01.002
Brief update on endocytosis of nanomedicines.
来源期刊：Advanced drug delivery reviewsDOI：10.1016/j.addr.2019.08.004
Design strategies for shape‐controlled magnetic iron oxide nanoparticles
来源期刊：Advanced Drug Delivery ReviewsDOI：10.1016/j.addr.2018.12.008
Physical stimuli-responsive vesicles in drug delivery: Beyond liposomes and polymersomes.
来源期刊：Advanced drug delivery reviewsDOI：10.1016/J.ADDR.2018.10.012
Bacteriophage interactions with mammalian tissue: Therapeutic applications.
来源期刊：Advanced drug delivery reviewsDOI：10.1016/j.addr.2019.01.003
Absorption, distribution, metabolism and excretion of the biomaterials used in Nanocarrier drug delivery systems.
来源期刊：Advanced drug delivery reviewsDOI：10.1016/j.addr.2019.06.008
Zebrafish as a preclinical in vivo screening model for nanomedicines.
来源期刊：Advanced drug delivery reviewsDOI：10.1016/j.addr.2019.01.001
Micromotors for drug delivery in vivo: The road ahead
来源期刊：Advanced Drug Delivery ReviewsDOI：10.1016/j.addr.2018.09.005
Approaches to physical stimulation of metallic nanoparticles for glioblastoma treatment
来源期刊：Advanced Drug Delivery ReviewsDOI：10.1016/j.addr.2018.10.013
Self-emulsifying drug delivery system: Mucus permeation and innovative quantification technologies.
来源期刊：Advanced drug delivery reviewsDOI：10.1016/j.addr.2019.04.001
Colloidal aspects of dispersion and digestion of self-dispersing lipid-based formulations for poorly water-soluble drugs.
来源期刊：Advanced drug delivery reviewsDOI：10.1016/j.addr.2019.01.008
Nanomedicines - Tiny particles and big challenges.
来源期刊：Advanced drug delivery reviewsDOI：10.1016/j.addr.2019.06.003
The blood-brain barrier: Physiology and strategies for drug delivery.
来源期刊：Advanced drug delivery reviewsDOI：10.1016/j.addr.2019.11.009
Rationally designed DNA-based nanocarriers.
来源期刊：Advanced drug delivery reviewsDOI：10.1016/j.addr.2019.02.003
Use of phage therapy to treat long-standing, persistent, or chronic bacterial infections.
来源期刊：Advanced drug delivery reviewsDOI：10.1016/J.ADDR.2018.06.018
Nanotechnology in cell replacement therapies for type 1 diabetes.
来源期刊：Advanced drug delivery reviewsDOI：10.1016/j.addr.2019.01.013
Thiolated polymers: Bioinspired polymers utilizing one of the most important bridging structures in nature.
来源期刊：Advanced drug delivery reviewsDOI：10.1016/j.addr.2019.04.007
The effect of low‐ and high‐penetration light on localized cancer therapy
来源期刊：Advanced Drug Delivery ReviewsDOI：10.1016/j.addr.2018.09.004
Lessons learned from intervertebral disc pathophysiology to guide rational design of sequential delivery systems for therapeutic biological factors.
来源期刊：Advanced drug delivery reviewsDOI：10.1016/j.addr.2019.08.007
Remotely controlled opening of delivery vehicles and release of cargo by external triggers.
来源期刊：Advanced drug delivery reviewsDOI：10.1016/j.addr.2018.10.003
Stem cell-based Lung-on-Chips: The best of both worlds?☆
来源期刊：Advanced Drug Delivery ReviewsDOI：10.1016/j.addr.2018.07.005
Carbohydrate-based nanocarriers and their application to target macrophages and deliver antimicrobial agents.
来源期刊：Advanced drug delivery reviewsDOI：10.1016/j.addr.2019.09.002
Drug therapies and delivery mechanisms to treat perturbed skin wound healing.
来源期刊：Advanced drug delivery reviewsDOI：10.1016/j.addr.2019.03.006
Chronopharmacology of glucocorticoids.
来源期刊：Advanced drug delivery reviewsDOI：10.1016/j.addr.2019.02.004
Non-transdermal microneedles for advanced drug delivery.
来源期刊：Advanced drug delivery reviewsDOI：10.1016/j.addr.2019.11.010
Optimizing Advances in Nanoparticle Delivery for Cancer Immunotherapy.
来源期刊：Advanced Drug Delivery ReviewsDOI：10.1016/J.ADDR.2019.07.009
Nanotechnology in peripheral nerve repair and reconstruction.
来源期刊：Advanced drug delivery reviewsDOI：10.1016/j.addr.2019.01.006
Lyophilized liposome-based parenteral drug development: Reviewing complex product design strategies and current regulatory environments.
来源期刊：Advanced drug delivery reviewsDOI：10.1016/j.addr.2019.03.003
Physical and chemical profiles of nanoparticles for lymphatic targeting.
来源期刊：Advanced drug delivery reviewsDOI：10.1016/j.addr.2019.09.005
Fundamentals of fractional laser-assisted drug delivery: An in-depth guide to experimental methodology and data interpretation.
来源期刊：Advanced drug delivery reviewsDOI：10.1016/j.addr.2019.10.003
Cardiac macrotissues-on-a-plate models for phenotypic drug screens.
来源期刊：Advanced drug delivery reviewsDOI：10.1016/j.addr.2019.03.002
A toll-like receptor 3 (TLR3) agonist ARNAX for therapeutic immunotherapy.
来源期刊：Advanced drug delivery reviewsDOI：10.1016/j.addr.2019.07.008
Reprogramming lymphocytes for the treatment of melanoma: From biology to therapy.
来源期刊：Advanced drug delivery reviewsDOI：10.1016/j.addr.2019.06.005
Intrinsic cancer vaccination.
来源期刊：Advanced drug delivery reviewsDOI：10.1016/j.addr.2019.05.007
Integrating nanomedicine into clinical radiotherapy regimens.
来源期刊：Advanced drug delivery reviewsDOI：10.1016/j.addr.2019.07.002
Variations in gastrointestinal lipases, pH and bile acid levels with food intake, age and diseases: Possible impact on oral lipid-based drug delivery systems.
来源期刊：Advanced drug delivery reviewsDOI：10.1016/j.addr.2019.03.005
Listening for the therapeutic window: Advances in drug delivery utilizing photoacoustic imaging.
来源期刊：Advanced drug delivery reviewsDOI：10.1016/j.addr.2019.07.003
Fibrosis in tissue engineering and regenerative medicine: treat or trigger?
来源期刊：Advanced drug delivery reviewsDOI：10.1016/j.addr.2019.07.007
Adenosine and lipids: A forced marriage or a love match?
来源期刊：Advanced drug delivery reviewsDOI：10.1016/j.addr.2019.02.005
Lymphatic changes in cancer and drug delivery to the lymphatics in solid tumors.
来源期刊：Advanced drug delivery reviewsDOI：10.1016/j.addr.2019.08.009
Advanced nanotherapies to promote neuroregeneration in the injured newborn brain.
来源期刊：Advanced drug delivery reviewsDOI：10.1016/j.addr.2019.10.005
Enabling biodegradable functional biomaterials for the management of neurological disorders.
来源期刊：Advanced drug delivery reviewsDOI：10.1016/j.addr.2019.06.004
Imaging and quantifying drug delivery in skin - Part 1: Autoradiography and mass spectrometry imaging.
来源期刊：Advanced drug delivery reviewsDOI：10.1016/j.addr.2019.11.004
Pharmacokinetics of nanotechnology-based formulations in pediatric populations.
来源期刊：Advanced drug delivery reviewsDOI：10.1016/j.addr.2019.08.008
A window into the brain: Tools to assess pre-clinical efficacy of biomaterials-based therapies on central nervous system disorders.
来源期刊：Advanced drug delivery reviewsDOI：10.1016/j.addr.2019.01.012
Technologies for intrapericardial delivery of therapeutics and cells.
来源期刊：Advanced drug delivery reviewsDOI：10.1016/j.addr.2019.02.006
RNA imaging by chemical probes.
来源期刊：Advanced drug delivery reviewsDOI：10.1016/j.addr.2019.08.001
Reprogramming the lymphocyte axis for advanced immunotherapy.
来源期刊：Advanced drug delivery reviewsDOI：10.1016/j.addr.2019.07.001
