DMPK publishes original and innovative scientific papers that address topics broadly related to xenobiotics. The term xenobiotic includes medicinal as well as environmental and agricultural chemicals and macromolecules. The journal is organized into sections as follows:- Drug metabolism / Biotransformation- Pharmacokinetics and pharmacodynamics- Toxicokinetics and toxicodynamics- Drug-drug interaction / Drug-food interaction- Mechanism of drug absorption and disposition (including transporter)- Drug delivery system- Clinical pharmacy and pharmacology- Analytical method- Factors affecting drug metabolism and transport- Expression of genes for drug-metabolizing enzymes and transporters- Pharmacogenetics and pharmacogenomics- Pharmacoepidemiology.
DMPK发表原创性和创新性的科学论文，涉及与外源性物质广泛相关的主题。术语异生素包括医药以及环境和农业化学品和大分子。该杂志分为以下几个部分：-药物代谢/生物转化-药代动力学和药效学-毒代动力学和毒理动力学-药物-药物相互作用/药物-食物相互作用-药物吸收和处置机制（包括转运蛋白）-药物递送系统-临床药学和药理学-分析方法-影响药物代谢和转运的因素-药物代谢酶和转运蛋白基因的表达-药物遗传学和药物遗传学-药物流行病学。
Therapeutic drug monitoring of monoclonal antibodies: Applicability based on their pharmacokinetic properties.
来源期刊：Drug metabolism and pharmacokineticsDOI：10.1016/j.dmpk.2018.11.003
Effect of OATP1B1 genotypes on plasma concentrations of endogenous OATP1B1 substrates and drugs, and their association in healthy volunteers.
来源期刊：Drug metabolism and pharmacokineticsDOI：10.1016/j.dmpk.2018.09.003
Development of a new Japanese guideline on drug interaction for drug development and appropriate provision of information.
来源期刊：Drug metabolism and pharmacokineticsDOI：10.1016/j.dmpk.2019.11.009
Minimal contribution of P-gp on the low brain distribution of naldemedine, a peripherally acting μ-opioid receptor antagonist.
来源期刊：Drug metabolism and pharmacokineticsDOI：10.1016/j.dmpk.2018.12.002
Importance of cynomolgus monkeys in development of monoclonal antibody drugs.
来源期刊：Drug metabolism and pharmacokineticsDOI：10.1016/j.dmpk.2018.02.003
Prediction of regioselectivity and preferred order of metabolisms on CYP1A2-mediated reactions part 3: Difference in substrate specificity of human and rodent CYP1A2 and the refinement of predicting system.
来源期刊：Drug metabolism and pharmacokineticsDOI：10.1016/J.DMPK.2019.02.001
Reconstitution of CYP3A4 active site through assembly of ligand interactions as a grid-template: Solving the modes of the metabolism and inhibition.
来源期刊：Drug metabolism and pharmacokineticsDOI：10.1016/j.dmpk.2018.10.001
Prediction of regioselectivity and preferred order of CYP1A1-mediated metabolism: Solving the interaction of human and rat CYP1A1 forms with ligands on the template system.
来源期刊：Drug metabolism and pharmacokineticsDOI：10.1016/j.dmpk.2019.10.008
Investigation of non-linear Mate1-mediated efflux of trimethoprim in the mouse kidney as the mechanism underlying drug-drug interactions between trimethoprim and organic cations in the kidney.
来源期刊：Drug metabolism and pharmacokineticsDOI：10.1016/j.dmpk.2018.08.005
Quantitative prediction of hepatic CYP3A activity using endogenous markers in healthy subjects after administration of CYP3A inhibitors or inducers.
来源期刊：Drug metabolism and pharmacokineticsDOI：10.1016/J.DMPK.2019.04.002
Improvement of pharmacokinetic properties of therapeutic antibodies by antibody engineering.
来源期刊：Drug metabolism and pharmacokineticsDOI：10.1016/j.dmpk.2018.10.003
rs622342A>C in SLC22A1 is associated with metformin pharmacokinetics and glycemic response.
来源期刊：Drug metabolism and pharmacokineticsDOI：10.1016/j.dmpk.2019.10.007
Solving the interactions of steroidal ligands with CYP3A4 using a grid-base template system.
来源期刊：Drug metabolism and pharmacokineticsDOI：10.1016/J.DMPK.2019.05.003
Quantitative investigation of hepatobiliary transport of [11C]telmisartan in humans by PET imaging.
来源期刊：Drug metabolism and pharmacokineticsDOI：10.1016/J.DMPK.2019.02.004
Microdosing clinical study to clarify pharmacokinetic and pharmacogenetic characteristics of atorvastatin in Japanese hypercholesterolemic patients.
来源期刊：Drug metabolism and pharmacokineticsDOI：10.1016/j.dmpk.2019.08.004
Computational prediction of cytochrome P450 inhibition and induction.
来源期刊：Drug metabolism and pharmacokineticsDOI：10.1016/j.dmpk.2019.11.006
Riboflavin transport mediated by riboflavin transporters (RFVTs/SLC52A) at the rat outer blood-retinal barrier.
来源期刊：Drug metabolism and pharmacokineticsDOI：10.1016/J.DMPK.2019.08.002
Proteomic analysis of small intestinal epithelial cells in antibiotic-treated mice: Changes in drug transporters and metabolizing enzymes.
来源期刊：Drug metabolism and pharmacokineticsDOI：10.1016/j.dmpk.2019.01.001
Non-synonymous genetic variants of flavin-containing monooxygenase 3 (FMO3) in cynomolgus macaques.
来源期刊：Drug metabolism and pharmacokineticsDOI：10.1016/j.dmpk.2018.09.001
Short-lasting inhibition of hepatic uptake transporter OATP1B1 by tyrosine kinase inhibitor pazopanib.
来源期刊：Drug metabolism and pharmacokineticsDOI：10.1016/J.DMPK.2019.08.001
Developmental changes in transporter and receptor protein expression levels at the rat blood-brain barrier based on quantitative targeted absolute proteomics.
来源期刊：Drug metabolism and pharmacokineticsDOI：10.1016/j.dmpk.2019.09.003
Factor Xa inhibitors in clinical practice: Comparison of pharmacokinetic profiles.
来源期刊：Drug metabolism and pharmacokineticsDOI：10.1016/j.dmpk.2019.10.005
Inhibitory kinetics of fruit components on CYP2C19 activity.
来源期刊：Drug metabolism and pharmacokineticsDOI：10.1016/J.DMPK.2019.02.002
Metabolomics study on the therapeutic effect of traditional Chinese medicine Xue-Fu-Zhu-Yu decoction in coronary heart disease based on LC-Q-TOF/MS and GC-MS analysis.
来源期刊：Drug metabolism and pharmacokineticsDOI：10.1016/J.DMPK.2019.07.004
The extent of drug-drug interaction between amlodipine and activated charcoal is attenuated by food intake in rats.
来源期刊：Drug metabolism and pharmacokineticsDOI：10.1016/j.dmpk.2018.08.008
Genetic variants of flavin-containing monooxygenase 3 (FMO3) derived from Japanese subjects with the trimethylaminuria phenotype and whole-genome sequence data from a large Japanese database.
来源期刊：Drug metabolism and pharmacokineticsDOI：10.1016/J.DMPK.2019.06.001
Pharmacokinetics and bioequivalence of low-dose clopidogrel in healthy Chinese volunteers under fasted and fed conditions.
来源期刊：Drug metabolism and pharmacokineticsDOI：10.1016/j.dmpk.2019.05.005
A spatial-temporal model for zonal hepatotoxicity of acetaminophen.
来源期刊：Drug metabolism and pharmacokineticsDOI：10.1016/j.dmpk.2018.09.266
Genotype-sensitive reversible and time-dependent CYP2D6 Inhibition in human liver microsomes
来源期刊：Drug Metabolism and PharmacokineticsDOI：10.1016/J.DMPK.2018.09.151
Relationships between plasma lactate, plasma alanine, genetic variations in lactate transporters and type 2 diabetes in the Japanese population.
来源期刊：Drug metabolism and pharmacokineticsDOI：10.1016/j.dmpk.2019.10.001
Comparison of mRNA expression profiles of drug-metabolizing enzymes and transporters in fresh and cryopreserved cynomolgus monkey hepatocytes.
来源期刊：Drug metabolism and pharmacokineticsDOI：10.1016/J.DMPK.2019.04.003
Influence of gastrointestinal activity on the absorption of nilotinib.
来源期刊：Drug metabolism and pharmacokineticsDOI：10.1016/j.dmpk.2019.08.006
Organic anion-transporting polypeptide 1a4-mediated heterogeneous distribution of sulforhodamine-101 in rat hepatic lobules.
来源期刊：Drug metabolism and pharmacokineticsDOI：10.1016/J.DMPK.2019.04.001
Pharmacokinetic modeling and simulation for dose rationale of doripenem in neonates and infants.
来源期刊：Drug metabolism and pharmacokineticsDOI：10.1016/j.dmpk.2019.10.003
Effects of food type on the extent of drug-drug interactions between activated charcoal and phenobarbital in rats.
来源期刊：Drug metabolism and pharmacokineticsDOI：10.1016/J.DMPK.2019.05.002
Evaluation of drug-drug interactions in drug metabolism: Differences and harmonization in guidance/guidelines.
来源期刊：Drug metabolism and pharmacokineticsDOI：10.1016/j.dmpk.2019.10.006
Transport of 2,4-dichloro phenoxyacetic acid by human Na+-coupled monocarboxylate transporter 1 (hSMCT1, SLC5A8).
来源期刊：Drug metabolism and pharmacokineticsDOI：10.1016/j.dmpk.2018.10.004
Development and validation of an LC-MS/MS method for vesicle assay using corning® Transportocells™ HEK293-derived ABC transporter membrane vesicles BCRP and MRP2
来源期刊：Drug Metabolism and PharmacokineticsDOI：10.1016/j.dmpk.2018.09.244
Physiologically based pharmacokinetic model predictions of ivosidenib (AG-120) as a victim and perpetrator of drug–drug interactions
来源期刊：Drug Metabolism and PharmacokineticsDOI：10.1016/j.dmpk.2018.09.238
Studies on the L-2-hydroxy-acid oxidase 2 catalyzed metabolism of S-mandelic acid and its analogues.
来源期刊：Drug metabolism and pharmacokineticsDOI：10.1016/j.dmpk.2019.02.003
Current status and future perspective on preclinical pharmacokinetic and pharmacodynamic (PK/PD) analysis: Survey in Japan pharmaceutical manufacturers association (JPMA).
来源期刊：Drug metabolism and pharmacokineticsDOI：10.1016/j.dmpk.2019.01.004
Characterization of human UGT2A3 expression using a prepared specific antibody against UGT2A3.
来源期刊：Drug metabolism and pharmacokineticsDOI：10.1016/J.DMPK.2019.05.001
Ex vivo whole liver perfusion model for prediction of drug-drug interactions and biliary excretion of rosuvastatin
来源期刊：Drug Metabolism and PharmacokineticsDOI：10.1016/J.DMPK.2018.09.172
Suppression of P-glycoprotein by cigarette smoke extract in human lung-derived A549/P-gp cells.
来源期刊：Drug metabolism and pharmacokineticsDOI：10.1016/j.dmpk.2019.12.001
Population pharmacokinetic and exposure-response analyses of guanfacine in Japanese pediatric ADHD patients.
来源期刊：Drug metabolism and pharmacokineticsDOI：10.1016/J.DMPK.2019.07.001
Identification and quantitation of enzyme and transporter contributions to hepatic clearance for the assessment of potential drug-drug interactions.
来源期刊：Drug metabolism and pharmacokineticsDOI：10.1016/j.dmpk.2019.11.007
pH-dependent transport kinetics of the human organic anion-transporting polypeptide 1A2.
来源期刊：Drug metabolism and pharmacokineticsDOI：10.1016/j.dmpk.2019.12.002
Pharmacokinetic assessment of alprazolam-induced neonatal abstinence syndrome using physiologically based pharmacokinetic model.
来源期刊：Drug metabolism and pharmacokineticsDOI：10.1016/j.dmpk.2019.09.002
Cisplatin, rather than oxaliplatin, increases paracellular permeability of LLC-PK1 cells via activating protein kinase C.
来源期刊：Drug metabolism and pharmacokineticsDOI：10.1016/j.dmpk.2019.09.001
The association between trough blood concentration and systemic exposure of tacrolimus: Comparison between once-daily (Advagraf®) and twice-daily (Prograf®) formulation in de novo kidney transplant recipients.
来源期刊：Drug metabolism and pharmacokineticsDOI：10.1016/j.dmpk.2019.10.004
