An important reference for all pharmacology and toxicology departments, DMD is also a valuable resource for medicinal chemists involved in drug design and biochemists with an interest in drug metabolism, expression of drug metabolizing enzymes, and regulation of drug metabolizing enzyme gene expression. Articles provide experimental results from in vitro and in vivo systems that bring you significant and original information on metabolism and disposition of endogenous and exogenous compounds, including pharmacologic agents and environmental chemicals.
DMD是所有药理学和毒理学部门的重要参考资料，也是参与药物设计的药物化学家和对药物代谢、药物代谢酶表达和药物代谢酶基因表达调控感兴趣的生物化学家的宝贵资源。文章提供了来自体外和体内系统的实验结果，为您提供了有关内源性和外源性化合物（包括药理学试剂和环境化学品）代谢和处置的重要和原始信息。
The Molecular Mechanism Regulating Diurnal Rhythm of Flavin-Containing Monooxygenase 5 in Mouse Liver
来源期刊：Drug Metabolism and DispositionDOI：10.1124/dmd.119.088450
A Comparison of Total and Plasma Membrane Abundance of Transporters in Suspended, Plated, Sandwich-Cultured Human Hepatocytes Versus Human Liver Tissue Using Quantitative Targeted Proteomics and Cell Surface Biotinylation
来源期刊：Drug Metabolism and DispositionDOI：10.1124/dmd.118.084988
The Presence of a Transporter-Induced Protein Binding Shift: A New Explanation for Protein-Facilitated Uptake and Improvement for In Vitro-In Vivo Extrapolation
来源期刊：Drug Metabolism and DispositionDOI：10.1124/dmd.118.085779
Pharmacokinetics, Metabolism, and Excretion of [14C]Esaxerenone, a Novel Mineralocorticoid Receptor Blocker in Humans
来源期刊：Drug Metabolism and DispositionDOI：10.1124/dmd.118.084897
Quantitation of Lysosomal Trapping of Basic Lipophilic Compounds Using In Vitro Assays and In Silico Predictions Based on the Determination of the Full pH Profile of the Endo-/Lysosomal System in Rat Hepatocytes
来源期刊：Drug Metabolism and DispositionDOI：10.1124/dmd.118.084541
Kinetics of Cyclophosphamide Metabolism in Humans, Dogs, Cats, and Mice and Relationship to Cytotoxic Activity and Pharmacokinetics
来源期刊：Drug Metabolism and DispositionDOI：10.1124/dmd.118.083766
Overcoming P-Glycoprotein–Mediated Drug Resistance with Noscapine Derivatives
来源期刊：Drug Metabolism and DispositionDOI：10.1124/dmd.118.083188
Apalutamide Absorption, Metabolism, and Excretion in Healthy Men, and Enzyme Reaction in Human Hepatocytes
来源期刊：Drug Metabolism and DispositionDOI：10.1124/dmd.118.084517
Physiology of the Neonatal Gastrointestinal System Relevant to the Disposition of Orally Administered Medications
来源期刊：Drug Metabolism and DispositionDOI：10.1124/dmd.118.084418
Time Course of Aldehyde Oxidase and Why It Is Nonlinear
来源期刊：Drug Metabolism and DispositionDOI：10.1124/dmd.118.085787
In Vitro Inhibition of Carboxylesterase 1 by Major Cannabinoids and Selected Metabolites
来源期刊：Drug Metabolism and DispositionDOI：10.1124/dmd.118.086074
GDC-0810 Pharmacokinetics and Transporter-Mediated Drug Interaction Evaluation with an Endogenous Biomarker in the First-in-Human, Dose Escalation Study
来源期刊：Drug Metabolism and DispositionDOI：10.1124/dmd.119.087924
Evaluation of Carbazeran 4-Oxidation and O6-Benzylguanine 8-Oxidation as Catalytic Markers of Human Aldehyde Oxidase: Impact of Cytosolic Contamination of Liver Microsomes
来源期刊：Drug Metabolism and DispositionDOI：10.1124/dmd.118.082099
Hepatic Organic Anion Transporting Polypeptide–Mediated Clearance in the Beagle Dog: Assessing In Vitro–In Vivo Relationships and Applying Cross-Species Empirical Scaling Factors to Improve Prediction of Human Clearance
来源期刊：Drug Metabolism and DispositionDOI：10.1124/dmd.118.084194
Clinical Extrapolation of the Effects of Dolutegravir and Other HIV Integrase Inhibitors on Folate Transport Pathways
来源期刊：Drug Metabolism and DispositionDOI：10.1124/dmd.119.087635
Identification and Characterization of Efflux Transporters That Modulate the Subtoxic Disposition of Diclofenac and Its Metabolites
来源期刊：Drug Metabolism and DispositionDOI：10.1124/dmd.119.086603
Stereoselective Oxidation Kinetics of Deoxycholate in Recombinant and Microsomal CYP3A Enzymes: Deoxycholate 19-Hydroxylation Is an In Vitro Marker of CYP3A7 Activity
来源期刊：Drug Metabolism and DispositionDOI：10.1124/dmd.119.086637
Age Dependency of Blood-Brain Barrier Penetration by cis- and trans-Permethrin in the Rat
来源期刊：Drug Metabolism and DispositionDOI：10.1124/dmd.118.084822
Hepatic Enzymes Relevant to the Disposition of (−)-∆9-Tetrahydrocannabinol (THC) and Its Psychoactive Metabolite, 11-OH-THC
来源期刊：Drug Metabolism and DispositionDOI：10.1124/dmd.118.085548
RNA Editing Enzymes Modulate the Expression of Hepatic CYP2B6, CYP2C8, and Other Cytochrome P450 Isoforms
来源期刊：Drug Metabolism and DispositionDOI：10.1124/dmd.119.086702
Rolapitant Is a Reversible Inhibitor of CYP2D6
来源期刊：Drug Metabolism and DispositionDOI：10.1124/dmd.118.085928
Impact of Lipid Partitioning on the Design, Analysis, and Interpretation of Microsomal Time-Dependent Inactivation
来源期刊：Drug Metabolism and DispositionDOI：10.1124/dmd.118.085969
An Innovative Approach to Characterize Clinical ADME and Pharmacokinetics of the Inhaled Drug Nemiralisib Using an Intravenous Microtracer Combined with an Inhaled Dose and an Oral Radiolabel Dose in Healthy Male Subjects
来源期刊：Drug Metabolism and DispositionDOI：10.1124/dmd.119.088344
Ginsenoside Rc Is a New Selective UGT1A9 Inhibitor in Human Liver Microsomes and Recombinant Human UGT Isoforms
来源期刊：Drug Metabolism and DispositionDOI：10.1124/dmd.119.087965
Interactions between Maraviroc and the ABCB1, ABCG2, and ABCC2 Transporters: An Important Role in Transplacental Pharmacokinetics
来源期刊：Drug Metabolism and DispositionDOI：10.1124/dmd.119.087684
Fraction Unbound for Liver Microsome and Hepatocyte Incubations for All Major Species Can Be Approximated Using a Single-Species Surrogate
来源期刊：Drug Metabolism and DispositionDOI：10.1124/dmd.118.085936
Altered Hepatobiliary Disposition of Tolvaptan and Selected Tolvaptan Metabolites in a Rodent Model of Polycystic Kidney Disease
来源期刊：Drug Metabolism and DispositionDOI：10.1124/dmd.118.083907
Induction of Cytochrome P450 Involved in the Accelerated Blood Clearance Phenomenon Induced by PEGylated Liposomes In Vivo
来源期刊：Drug Metabolism and DispositionDOI：10.1124/dmd.118.085340
Glucocorticoids Increase Renal Excretion of Urate in Mice by Downregulating Urate Transporter 1
来源期刊：Drug Metabolism and DispositionDOI：10.1124/dmd.119.087700
The MBNL/CELF Splicing Factors Regulate Cytosolic Sulfotransferase 4A1 Protein Expression during Cell Differentiation
来源期刊：Drug Metabolism and DispositionDOI：10.1124/dmd.118.085290
Systematic Development and Verification of a Physiologically Based Pharmacokinetic Model of Rivaroxaban
来源期刊：Drug Metabolism and DispositionDOI：10.1124/dmd.119.086918
Role of ABCG2 in Secretion into Milk of the Anti-Inflammatory Flunixin and Its Main Metabolite: In Vitro-In Vivo Correlation in Mice and Cows
来源期刊：Drug Metabolism and DispositionDOI：10.1124/dmd.118.085506
Mechanism of H2S Formation from the Metabolism of Anetholedithiolethione and Anetholedithiolone by Rat Liver Microsomes
来源期刊：Drug Metabolism and DispositionDOI：10.1124/dmd.119.087205
Use of Segregated Hepatocyte Scaling Factors and Cross-Species Relationships to Resolve Clearance Dependence in the Prediction of Human Hepatic Clearance
来源期刊：Drug Metabolism and DispositionDOI：10.1124/dmd.118.085191
Hepatocyte Concentrations of Imaging Compounds Associated with Transporter Inhibition: Evidence in Perfused Rat Livers
来源期刊：Drug Metabolism and DispositionDOI：10.1124/dmd.118.084624
Role of l- and d-Menthol in the Glucuronidation and Detoxification of the Major Lung Carcinogen, NNAL
来源期刊：Drug Metabolism and DispositionDOI：10.1124/dmd.119.088351
Rhinacanthin-C Mediated Herb-Drug Interactions with Drug Transporters and Phase I Drug-Metabolizing Enzymes
来源期刊：Drug Metabolism and DispositionDOI：10.1124/dmd.118.085647
An Accurate In Vitro Prediction of Human VDss Based on the Øie–Tozer Equation and Primary Physicochemical Descriptors. 3. Analysis and Assessment of Predictivity on a Large Dataset
来源期刊：Drug Metabolism and DispositionDOI：10.1124/dmd.119.088914
Drug and Chemical Glucosidation by Control Supersomes and Membranes from Spodoptera frugiperda (Sf) 9 Cells: Implications for the Apparent Glucuronidation of Xenobiotics by UDP-glucuronosyltransferase 1A5
来源期刊：Drug Metabolism and DispositionDOI：10.1124/dmd.118.084947
Carboxylesterase 2 and Intestine Transporters Contribute to the Low Bioavailability of Allisartan, a Prodrug of Exp3174 for Hypertension Treatment in Humans
来源期刊：Drug Metabolism and DispositionDOI：10.1124/dmd.118.085092
Hydrolytic Metabolism of Cyanopyrrolidine DPP-4 Inhibitors Mediated by Dipeptidyl Peptidases
来源期刊：Drug Metabolism and DispositionDOI：10.1124/dmd.118.084640
CYP2D1 Gene Knockout Reduces the Metabolism and Efficacy of Venlafaxine in Rats
来源期刊：Drug Metabolism and DispositionDOI：10.1124/dmd.119.088526
Investigating the Impact of Albumin on the Liver Uptake of Pitavastatin and Warfarin in Nagase Analbuminemic Rats
来源期刊：Drug Metabolism and DispositionDOI：10.1124/dmd.119.088278
Brain Distributional Kinetics of a Novel MDM2 Inhibitor SAR405838: Implications for Use in Brain Tumor Therapy
来源期刊：Drug Metabolism and DispositionDOI：10.1124/dmd.119.088716
Correction to “In Vitro Hepatic Oxidative Biotransformation of Trimethoprim”
来源期刊：Drug Metabolism and DispositionDOI：10.1124/dmd.117.065193err
Gas-Phase Rearrangement of the O-Glucuronide of Vildagliptin Forms Product-Ion Fragments Suggesting Wrongly an N-Glucuronide
来源期刊：Drug Metabolism and DispositionDOI：10.1124/dmd.118.085597
Potential for Underestimation of d-Methylphenidate Bioavailability Using Chiral Derivatization/Gas Chromatography
来源期刊：Drug Metabolism and DispositionDOI：10.1124/dmd.119.087189
Indinavir Increases Midazolam N-Glucuronidation in Humans: Identification of an Alternate CYP3A Inhibitor Using an In Vitro to In Vivo Approach
来源期刊：Drug Metabolism and DispositionDOI：10.1124/dmd.119.087007
Suppression of Hepatic CYP3A4 Expression and Activity by 3-Methylcholanthrene in Humanized PXR-CAR-CYP3A4/3A7 Mice
来源期刊：Drug Metabolism and DispositionDOI：10.1124/dmd.118.084509
Development of a Gold Nanoparticle–Functionalized Surface Plasmon Resonance Assay for the Sensitive Detection of Monoclonal Antibodies and Its Application in Pharmacokinetics
来源期刊：Drug Metabolism and DispositionDOI：10.1124/dmd.119.086249
