Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.
药物化学的当前主题是一个论坛，对药物化学家和其他相关学科的人感兴趣的领域进行评论。每一期都专门讨论一个特定的主题，包含六至九篇评论，为读者提供该领域的全面概览。作为审查主题专家的客座编辑将汇编每期。《药物化学最新主题》涵盖药物化学的所有领域，包括合理药物设计、合成化学、生物有机化学、高通量筛选、组合化学、化合物多样性测量、药物吸收、药物分布、代谢、新的和正在出现的药物靶点、天然产物、药物基因组学和构效关系的最新进展。药物化学是一门迅速成熟的学科。研究结构和功能之间的关系对于理解生命的分子基础是绝对必要的。药物化学的当前主题旨在促进科学知识和洞察力的增长，并促进新的治疗剂的发现和开发，以治疗衰弱的人类疾病。该杂志是必不可少的每一个药物化学家谁希望保持知情和最新的最新和最重要的进展。
Biological Activities of Artemisinin Derivatives Beyond Malaria.
来源期刊：Current topics in medicinal chemistryDOI：10.2174/1568026619666190122144217
Quantum Molecular Dynamics, Topological, Group Theoretical and Graph Theoretical Studies of Protein-Protein Interactions.
来源期刊：Current topics in medicinal chemistryDOI：10.2174/1568026619666190304152704
Peptide Sequence-Dominated Enzyme-Responsive Nanoplatform for Anticancer Drug Delivery.
来源期刊：Current topics in medicinal chemistryDOI：10.2174/1568026619666190125144621
An Overview on the Potential Antimycobacterial Agents Targeting Serine/Threonine Protein Kinases from Mycobacterium tuberculosis.
来源期刊：Current topics in medicinal chemistryDOI：10.2174/1568026619666190227182701
Design, Synthesis, Evaluation of Antimicrobial Activity and Docking Studies of New Thiazole-based Chalcones.
来源期刊：Current topics in medicinal chemistryDOI：10.2174/1568026619666190129121933
Peptides as Potential Anticancer Agents.
来源期刊：Current topics in medicinal chemistryDOI：10.2174/1568026619666190125161517
Mathematical Modeling to Address Challenges in Pancreatic Cancer.
来源期刊：Current topics in medicinal chemistryDOI：10.2174/1568026620666200101095641
Prediction of Drug-Drug Interactions Related to Inhibition or Induction of Drug-Metabolizing Enzymes.
来源期刊：Current topics in medicinal chemistryDOI：10.2174/1568026619666190123160406
Xenobiotic Metabolising Enzymes: Impact on Pathologic Conditions, Drug Interactions and Drug Design.
来源期刊：Current topics in medicinal chemistryDOI：10.2174/1568026619666190129122727
Recent Progress in Machine Learning-based Prediction of Peptide Activity for Drug Discovery.
来源期刊：Current topics in medicinal chemistryDOI：10.2174/1568026619666190122151634
An Overview of HDAC Inhibitors and their Synthetic Routes.
来源期刊：Current topics in medicinal chemistryDOI：10.2174/1568026619666190227221507
Activation of Transient Receptor Potential Vanilloid (TRPV) 4 as a Therapeutic Strategy in Osteoarthritis.
来源期刊：Current topics in medicinal chemistryDOI：10.2174/1568026619666191010162850
Griseofulvin derivatives: Synthesis, molecular docking and biological evaluation.
来源期刊：Current topics in medicinal chemistryDOI：10.2174/1568026619666190523080136
The Use of Conformational Restriction in Medicinal Chemistry.
来源期刊：Current topics in medicinal chemistryDOI：10.2174/1568026619666190712205025
ABC transporters in neurological disorders: an important gateway for botanical compounds mediated neuro-therapeutics.
来源期刊：Current topics in medicinal chemistryDOI：10.2174/1568026619666190412121811
Progress in the Mechanism and Clinical Application of Cilostazol.
来源期刊：Current topics in medicinal chemistryDOI：10.2174/1568026619666191122123855
Screening of Anti-mycobacterial Phytochemical Compounds for Potential Inhibitors against Mycobacterium Tuberculosis Isocitrate Lyase.
来源期刊：Current topics in medicinal chemistryDOI：10.2174/1568026619666190304125603
In Vitro and In Silico Studies of Glycyrrhetinic acid derivatives as Anti-Filarial Agents.
来源期刊：Current topics in medicinal chemistryDOI：10.2174/1568026619666190618141450
New mechanistic insight on the PIM-1 kinase inhibitor AZD1208 using multidrug resistant human erythroleukemia cell lines and molecular docking simulations.
来源期刊：Current topics in medicinal chemistryDOI：10.2174/1568026619666190509121606
Epigenetic Regulation and Drug Discovery for Cancer Therapy.
来源期刊：Current topics in medicinal chemistryDOI：10.2174/156802661912190730153906
Targeting DNA Gyrase to Combat Mycobacterium tuberculosis: An Update.
来源期刊：Current topics in medicinal chemistryDOI：10.2174/1568026619666190304130218
New and Promising Chemotherapeutics for Emerging Infections Involving Drug-Resistant Non-albicans Candida Species.
来源期刊：Current topics in medicinal chemistryDOI：10.2174/1568026619666191025152412
Fragment Based Approaches for Allosteric Metabotropic Glutamate Receptor (mGluR) Modulators.
来源期刊：Current topics in medicinal chemistryDOI：10.2174/1568026619666190808150039
Molecules and Metabolites from Natural Products as Inhibitors of Biofilm in Candida spp. pathogens.
来源期刊：Current topics in medicinal chemistryDOI：10.2174/1568026619666191025154834
Biological production of (S)-acetoin: a state-of-the-art review.
来源期刊：Current topics in medicinal chemistryDOI：10.2174/1568026619666191018111424
The discovery and development of oxalamide and pyrrole small molecule inhibitors of gp120 and HIV entry.
来源期刊：Current topics in medicinal chemistryDOI：10.2174/1568026619666190717163959
Resveratrol in Various Pockets: A Review.
来源期刊：Current topics in medicinal chemistryDOI：10.2174/1568026619666190301173958
Neuroprotection with natural antioxidants and nutraceuticals in the context of brain cell degeneration: The epigenetic connection.
来源期刊：Current topics in medicinal chemistryDOI：10.2174/1568026619666191202155738
Recent Advances in Developing K-Ras Plasma Membrane Localization Inhibitors.
来源期刊：Current topics in medicinal chemistryDOI：10.2174/1568026619666190902145116
Utilization of the Plant Clusia fluminensis Planch & Triana Against Some Toxic Activities of the Venom of Bothrops jararaca and B. jararacussu Snake Venom Toxic activities.
来源期刊：Current topics in medicinal chemistryDOI：10.2174/1568026619666190724160711
Recent Advances of Small Molecular Regulators Targeting G Protein-Coupled Receptors Family for Oncology Immunotherapy.
来源期刊：Current topics in medicinal chemistryDOI：10.2174/1568026619666190628115644
Sperm quality in mouse after exposure to low doses of TCDD.
来源期刊：Current topics in medicinal chemistryDOI：10.2174/1568026619666190520090132
GPCRs and Insulin Receptor Signaling in Conversation: Novel Avenues for Drug Discovery.
来源期刊：Current topics in medicinal chemistryDOI：10.2174/1568026619666190712211642
Herbal Medicine of the 21st Century: A Focus on the Chemistry, Pharmacokinetics and Toxicity of Five Widely Advocated Phytotherapies.
来源期刊：Current topics in medicinal chemistryDOI：10.2174/1568026619666191112121330
In-silico designing, ADMET Analysis, synthesis and biological evaluation of novel derivatives of diosmin against urease protein and Helicobactor Pylori bacterium.
来源期刊：Current topics in medicinal chemistryDOI：10.2174/1568026619666191114123452
PET Imaging of Adenosine Receptors in Diseases.
来源期刊：Current topics in medicinal chemistryDOI：10.2174/1568026619666190708163407
A comprehensive review of the genus Pyrola herbs in traditional uses, phytochemistry and pharmacological activities.
来源期刊：Current topics in medicinal chemistryDOI：10.2174/1568026619666191203112412
Overview of Current Immunotherapies Targeting Mutated KRAS Cancers.
来源期刊：Current topics in medicinal chemistryDOI：10.2174/1568026619666190904163524
Machine Learning as proposal for a better application of food nanotechnology regulation in European Union.
来源期刊：Current topics in medicinal chemistryDOI：10.2174/1568026619666191205152538
In Vitro, In Silico and Ex Vivo Studies of Dihydroartemisinin Derivatives as Antitubercular Agents.
来源期刊：Current topics in medicinal chemistryDOI：10.2174/1568026619666190305131425
Tryptanthrin Analogues as Inhibitors of Enoyl-acyl Carrier Protein Reductase: Activity against Mycobacterium tuberculosis, Toxicity, Modeling of Enzyme Binding.
来源期刊：Current topics in medicinal chemistryDOI：10.2174/1568026619666190304125740
Synthesis, Biological Evaluation and Molecular Docking Studies of Novel Di-hydropyridine Analogs as Potent Antioxidants.
来源期刊：Current Topics in Medicinal ChemistryDOI：10.2174/1568026619666191105100959
Pumping O2 with no N2- An Overview of Hollow Fiber Membrane Oxygenators with Integrated Arterial Filters.
来源期刊：Current topics in medicinal chemistryDOI：10.2174/1568026619666191210161013
Efficient Synthesis and Antibacterial Profile of Bis(2-hydroxynaphthalene-1,4-dione).
来源期刊：Current topics in medicinal chemistryDOI：10.2174/1568026619666191210160342
Insights into the Structural Aspects of the mGlu Receptor Orthosteric Binding Site.
来源期刊：Current topics in medicinal chemistryDOI：10.2174/1568026619666191011094935
Synthesis, in vitro and in silico studies of indolequinone derivatives against clinically relevant bacterial pathogens.
来源期刊：Current topics in medicinal chemistryDOI：10.2174/1568026620666191223110518
Protein Activation in Drug Discovery - Part-I.
来源期刊：Current topics in medicinal chemistryDOI：10.2174/156802661924191113152840
Exploration of medicinal plants as sources of novel anticandidal drugs.
来源期刊：Current topics in medicinal chemistryDOI：10.2174/1568026619666191025155856
Recent Advances in Medicinal Chemistry to Treat Filariasis and Helminthiasis.
来源期刊：Current topics in medicinal chemistryDOI：10.2174/156802661914190828124745
