Clinical and Translational Science (CTS), an official journal of the American Society for Clinical Pharmacology and Therapeutics, highlights original translational medicine research that helps bridge laboratory discoveries with the diagnosis and treatment of human disease. Translational medicine is a multi-faceted discipline with a focus on translational therapeutics. In a broad sense, translational medicine bridges across the discovery, development, regulation, and utilization spectrum. Research may appear as Full Articles, Brief Reports, Commentaries, Phase Forwards (clinical trials), Reviews, or Tutorials. CTS also includes invited didactic content that covers the connections between clinical pharmacology and translational medicine. Best-in-class methodologies and best practices are also welcomed as Tutorials. These additional features provide context for research articles and facilitate understanding for a wide array of individuals interested in clinical and translational science. CTS welcomes high quality, scientifically sound, original manuscripts focused on clinical pharmacology and translational science, including animal, in vitro, in silico, and clinical studies supporting the breadth of drug discovery, development, regulation and clinical use of both traditional drugs and innovative modalities.
《临床与转化科学》（CTS）是美国临床药理学和治疗学学会的官方期刊，重点介绍有助于将实验室发现与人类疾病的诊断和治疗联系起来的原创转化医学研究。转化医学是一门以转化治疗学为核心的多学科。从广义上讲，转化医学跨越了发现、开发、监管和利用的光谱。研究可能以全文、简要报告、评论、阶段前瞻（临床试验）、综述或教程的形式出现。CTS还包括邀请教学内容，涵盖临床药理学和转化医学之间的联系。最佳的方法和最佳实践也欢迎作为教程。这些附加功能为研究文章提供了上下文，并有助于对临床和转化科学感兴趣的广泛个人的理解。CTS欢迎关注临床药理学和转化科学的高质量、科学合理的原始手稿，包括动物、体外、计算机模拟和临床研究，支持传统药物和创新药物的广泛药物发现、开发、监管和临床使用。
Standardizing CYP2D6 Genotype to Phenotype Translation: Consensus Recommendations from the Clinical Pharmacogenetics Implementation Consortium and Dutch Pharmacogenetics Working Group
来源期刊：Clinical and Translational ScienceDOI：10.1111/cts.12692
Design and Conduct Considerations for First‐in‐Human Trials
来源期刊：Clinical and Translational ScienceDOI：10.1111/cts.12582
Continuous Monitoring Using a Wearable Device Detects Activity‐Induced Heart Rate Changes After Administration of Amphetamine
来源期刊：Clinical and Translational ScienceDOI：10.1111/cts.12673
The Biomedical Data Translator Program: Conception, Culture, and Community
来源期刊：Clinical and Translational ScienceDOI：10.1111/cts.12592
A Modeling Framework to Characterize Cytokine Release upon T‐Cell–Engaging Bispecific Antibody Treatment: Methodology and Opportunities
来源期刊：Clinical and Translational ScienceDOI：10.1111/cts.12662
Use of Titration as a Therapeutic Individualization Strategy: An Analysis of Food and Drug Administration–Approved Drugs
来源期刊：Clinical and Translational ScienceDOI：10.1111/cts.12626
Electrocardiographic Effects of a Supratherapeutic Dose of WCK 2349, a Benzoquinolizine Fluoroquinolone
来源期刊：Clinical and Translational ScienceDOI：10.1111/cts.12594
VKORC1 and Novel CYP2C9 Variation Predict Warfarin Response in Alaska Native and American Indian People
来源期刊：Clinical and Translational ScienceDOI：10.1111/cts.12611
PF‐04447943, a Phosphodiesterase 9A Inhibitor, in Stable Sickle Cell Disease Patients: A Phase Ib Randomized, Placebo‐Controlled Study
来源期刊：Clinical and Translational ScienceDOI：10.1111/cts.12604
Clinical Utility of Pharmacogene Panel‐Based Testing in Patients Undergoing Percutaneous Coronary Intervention
来源期刊：Clinical and Translational ScienceDOI：10.1111/cts.12729
The Labyrinth of Product Development and Regulatory Approvals in Liquid Biopsy Diagnostics
来源期刊：Clinical and Translational ScienceDOI：10.1111/cts.12657
Identification and Evaluation of Clinical Substrates of Organic Anion Transporting Polypeptides 1B1 and 1B3
来源期刊：Clinical and Translational ScienceDOI：10.1111/cts.12623
Psychological and Genetic Predictors of Pain Tolerance
来源期刊：Clinical and Translational ScienceDOI：10.1111/cts.12605
Interaction Between Sex and Organic Anion‐Transporting Polypeptide 1b2 on the Pharmacokinetics of Regorafenib and Its Metabolites Regorafenib‐N‐Oxide and Regorafenib‐Glucuronide in Mice
来源期刊：Clinical and Translational ScienceDOI：10.1111/cts.12630
Prediction of Nephropathy in Type 2 Diabetes: An Analysis of the ACCORD Trial Applying Machine Learning Techniques
来源期刊：Clinical and Translational ScienceDOI：10.1111/cts.12647
Does In Vitro Cytochrome P450 Downregulation Translate to In Vivo Drug‐Drug Interactions? Preclinical and Clinical Studies With 13‐cis‐Retinoic Acid
来源期刊：Clinical and Translational ScienceDOI：10.1111/cts.12616
Safety, Tolerability, and Pharmacokinetics of the β‐Site Amyloid Precursor Protein‐Cleaving Enzyme 1 Inhibitor Verubecestat (MK‐8931) in Healthy Elderly Male and Female Subjects
来源期刊：Clinical and Translational ScienceDOI：10.1111/cts.12645
Emerging Insights on the Interaction Between Anticancer and Immunosuppressant Drugs and Intestinal Microbiota in Pediatric Patients
来源期刊：Clinical and Translational ScienceDOI：10.1111/cts.12722
Regulatory Affairs 101: Introduction to Investigational New Drug Applications and Clinical Trial Applications
来源期刊：Clinical and Translational ScienceDOI：10.1111/cts.12635
No Effect of Digoxin on Rosuvastatin Pharmacokinetics in Healthy Subjects: Utility of Oita Combination for Clinical Drug–Drug Interaction Study
来源期刊：Clinical and Translational ScienceDOI：10.1111/cts.12646
Characteristics of Single Pivotal Trials Supporting Regulatory Approvals of Novel Non‐orphan, Non‐oncology Drugs in the European Union and United States from 2012−2016
来源期刊：Clinical and Translational ScienceDOI：10.1111/cts.12617
Translating Minimally Invasive Glaucoma Surgery Devices
来源期刊：Clinical and Translational ScienceDOI：10.1111/cts.12660
CYP2B6 Genotype‐Dependent Inhibition of CYP1A2 and Induction of CYP2A6 by the Antiretroviral Drug Efavirenz in Healthy Volunteers
来源期刊：Clinical and Translational ScienceDOI：10.1111/cts.12671
Variability in In Vitro OATP1B1/1B3 Inhibition Data: Impact of Incubation Conditions on Variability and Subsequent Drug Interaction Predictions
来源期刊：Clinical and Translational ScienceDOI：10.1111/cts.12691
The FDA’s Regulatory Framework for Chimeric Antigen Receptor‐T Cell Therapies
来源期刊：Clinical and Translational ScienceDOI：10.1111/cts.12666
Newborn Metabolic Profile Associated with Hyperbilirubinemia With and Without Kernicterus
来源期刊：Clinical and Translational ScienceDOI：10.1111/cts.12590
Prediction of Human Pharmacokinetics of Antibody–Drug Conjugates From Nonclinical Data
来源期刊：Clinical and Translational ScienceDOI：10.1111/cts.12649
Reduced Risk of Sinusoidal Obstruction Syndrome of the Liver after Busulfan‐Cyclophosphamide Conditioning Prior to Allogeneic Hematopoietic Stem Cell Transplantation
来源期刊：Clinical and Translational ScienceDOI：10.1111/cts.12709
Model‐Informed Dosing of Venetoclax in Healthy Subjects: An Exposure−Response Analysis
来源期刊：Clinical and Translational ScienceDOI：10.1111/cts.12665
Unveiling the Genetic Architecture of Human Disease for Precision Medicine
来源期刊：Clinical and Translational ScienceDOI：10.1111/cts.12593
Itraconazole Increases Ibrutinib Exposure 10‐Fold and Reduces Interindividual Variation—A Potentially Beneficial Drug‐Drug Interaction
来源期刊：Clinical and Translational ScienceDOI：10.1111/cts.12716
Impact of Disease and Treatment Response in Drug–Drug Interaction Studies: Osimertinib and Simvastatin in Advanced Non‐Small Cell Lung Cancer
来源期刊：Clinical and Translational ScienceDOI：10.1111/cts.12688
Models of Variability and Circadian Rhythm in Heart Rate, Blood Pressure, and QT Interval for Healthy Subjects Who Received Placebo in Phase I Trials
来源期刊：Clinical and Translational ScienceDOI：10.1111/cts.12640
siRNA Targeting and Treatment of Gastrointestinal Diseases
来源期刊：Clinical and Translational ScienceDOI：10.1111/cts.12668
Dosage Regimens for Meropenem in Children with Pseudomonas Infections Do Not Meet Serum Concentration Targets
来源期刊：Clinical and Translational ScienceDOI：10.1111/cts.12710
Effect of Acid‐Suppressive Strategies on Pazopanib Efficacy in Patients With Soft‐Tissue Sarcoma
来源期刊：Clinical and Translational ScienceDOI：10.1111/cts.12648
Analysis of Global Drug Development Pathways and Postmarketing Safety in Japan: Local Studies May Reduce Drug‐Related Deaths
来源期刊：Clinical and Translational ScienceDOI：10.1111/cts.12631
Effect of Genetic and Nongenetic Factors on the Clinical Response to Mineralocorticoid Receptor Antagonist Therapy in Egyptians with Heart Failure
来源期刊：Clinical and Translational ScienceDOI：10.1111/cts.12702
A Physiologically‐Based Pharmacokinetic Model for Targeting Calcitriol‐Conjugated Quantum Dots to Inflammatory Breast Cancer Cells
来源期刊：Clinical and Translational ScienceDOI：10.1111/cts.12664
Relationships Between Allopurinol Dose, Oxypurinol Concentration and Urate‐Lowering Response—In Search of a Minimum Effective Oxypurinol Concentration
来源期刊：Clinical and Translational ScienceDOI：10.1111/cts.12686
I‐Corps at NIH: Entrepreneurial Training Program Creating Successful Small Businesses
来源期刊：Clinical and Translational ScienceDOI：10.1111/cts.12637
Predicting In Vivo Efficacy from In Vitro Data: Quantitative Systems Pharmacology Modeling for an Epigenetic Modifier Drug in Cancer
来源期刊：Clinical and Translational ScienceDOI：10.1111/cts.12727
From Patient to Molecule: In Pursuit of Universal Treatments for TB
来源期刊：Clinical and Translational ScienceDOI：10.1111/cts.12718
Involve Children and Parents in Clinical Studies
来源期刊：Clinical and Translational ScienceDOI：10.1111/cts.12696
Pivotal Considerations for Optimal Deployment of Healthy Volunteers in Oncology Drug Development
来源期刊：Clinical and Translational ScienceDOI：10.1111/cts.12703
A Proposal of Conducting Bioequivalence Trials with Gastric pH Modulators for Two Oral Formulations Demonstrating Different Dissolution Profiles at Elevated pH
来源期刊：Clinical and Translational ScienceDOI：10.1111/cts.12658
Comparing Model Performance in Characterizing the PK/PD of the Anti‐Myostatin Antibody Domagrozumab
来源期刊：Clinical and Translational ScienceDOI：10.1111/cts.12693
The Advantages and Challenges of Using Real‐World Data for Patient Care
来源期刊：Clinical and Translational ScienceDOI：10.1111/cts.12683
Odds of Acute Kidney Injury in Patients Receiving Dipeptidyl Peptidase 4 Inhibitors: A National Cohort Study Within the Department of Veterans Affairs
来源期刊：Clinical and Translational ScienceDOI：10.1111/cts.12676
Prediction of Metabolite‐to‐Parent Drug Exposure: Derivation and Application of a Mechanistic Static Model
来源期刊：Clinical and Translational ScienceDOI：10.1111/cts.12734
