npj Systems Biology and Applications is an online Open Access journal dedicated to publishing the premier research that takes a systems-oriented approach. The journal aims to provide a forum for the presentation of articles that help define this nascent field, as well as those that apply the advances to wider fields. We encourage studies that integrate, or aid the integration of, data, analyses and insight from molecules to organisms and broader systems. Important areas of interest include not only fundamental biological systems and drug discovery, but also applications to health, medical practice and implementation, big data, biotechnology, food science, human behaviour, broader biological systems and industrial applications of systems biology.We encourage all approaches, including network biology, application of control theory to biological systems, computational modelling and analysis, comprehensive and/or high-content measurements, theoretical, analytical and computational studies of system-level properties of biological systems and computational/software/data platforms enabling such studies.
《npj系统生物学与应用》是一本在线开放获取期刊，致力于发表采用系统导向方法的首要研究。该杂志旨在提供一个论坛，介绍有助于定义这一新兴领域的文章，以及那些将进展应用到更广泛领域的文章。我们鼓励整合或帮助整合从分子到有机体和更广泛系统的数据、分析和见解的研究。我们感兴趣的重要领域不仅包括基础生物系统和药物发现，还包括在健康、医疗实践和实施、大数据、生物技术、食品科学、人类行为、更广泛的生物系统和系统生物学的工业应用方面的应用。我们鼓励所有方法，包括网络生物学、控制理论在生物系统中的应用、计算建模和分析、全面和/或高内容的测量，生物系统的系统级特性的理论、分析和计算研究，以及能够进行此类研究的计算/软件/数据平台。
iOmicsPASS: network-based integration of multiomics data for predictive subnetwork discovery.
来源期刊：NPJ systems biology and applicationsDOI：10.1038/s41540-019-0099-y
Synergy from gene expression and network mining (SynGeNet) method predicts synergistic drug combinations for diverse melanoma genomic subtypes
来源期刊：NPJ Systems Biology and ApplicationsDOI：10.1038/s41540-019-0085-4
Differential metabolic activity and discovery of therapeutic targets using summarized metabolic pathway models
来源期刊：NPJ Systems Biology and ApplicationsDOI：10.1038/s41540-019-0087-2
Flux sampling is a powerful tool to study metabolism under changing environmental conditions.
来源期刊：NPJ systems biology and applicationsDOI：10.1038/s41540-019-0109-0
Parsimonious Gene Correlation Network Analysis (PGCNA): a tool to define modular gene co-expression for refined molecular stratification in cancer
来源期刊：NPJ Systems Biology and ApplicationsDOI：10.1038/s41540-019-0090-7
Novel insights into gene expression regulation during meiosis revealed by translation elongation dynamics
来源期刊：NPJ Systems Biology and ApplicationsDOI：10.1038/s41540-019-0089-0
The multiplex network of human diseases.
来源期刊：NPJ systems biology and applicationsDOI：10.1038/s41540-019-0092-5
From expression footprints to causal pathways: contextualizing large signaling networks with CARNIVAL.
来源期刊：NPJ systems biology and applicationsDOI：10.1038/s41540-019-0118-z
Defining subpopulations of differential drug response to reveal novel target populations.
来源期刊：NPJ systems biology and applicationsDOI：10.1038/s41540-019-0113-4
Simulation of heterosis in a genome-scale metabolic network provides mechanistic explanations for increased biomass production rates in hybrid plants
来源期刊：NPJ Systems Biology and ApplicationsDOI：10.1038/s41540-019-0101-8
A yield-cost tradeoff governs Escherichia coli’s decision between fermentation and respiration in carbon-limited growth
来源期刊：NPJ Systems Biology and ApplicationsDOI：10.1038/s41540-019-0093-4
Identification of hyper-rewired genomic stress non-oncogene addiction genes across 15 cancer types
来源期刊：NPJ Systems Biology and ApplicationsDOI：10.1038/s41540-019-0104-5
Defining rules for cancer cell proliferation in TRAIL stimulation
来源期刊：NPJ Systems Biology and ApplicationsDOI：10.1038/s41540-019-0084-5
Genetic signature related to heme-hemoglobin metabolism pathway in sepsis secondary to pneumonia.
来源期刊：NPJ systems biology and applicationsDOI：10.1038/s41540-019-0105-4
ModelBricks-modules for reproducible modeling improving model annotation and provenance.
来源期刊：NPJ systems biology and applicationsDOI：10.1038/s41540-019-0114-3
Mechanistically detailed systems biology modeling of the HGF/Met pathway in hepatocellular carcinoma
来源期刊：NPJ Systems Biology and ApplicationsDOI：10.1038/s41540-019-0107-2
A data driven approach reveals disease similarity on a molecular level.
来源期刊：NPJ systems biology and applicationsDOI：10.1038/s41540-019-0117-0
A network-based approach to uncover microRNA-mediated disease comorbidities and potential pathobiological implications
来源期刊：NPJ Systems Biology and ApplicationsDOI：10.1038/s41540-019-0115-2
Identification of an early cell fate regulator by detecting dynamics in transcriptional heterogeneity and co-regulation during astrocyte differentiation
来源期刊：NPJ Systems Biology and ApplicationsDOI：10.1038/s41540-019-0095-2
Publisher Correction: ComPath: an ecosystem for exploring, analyzing, and curating mappings across pathway databases
来源期刊：NPJ Systems Biology and ApplicationsDOI：10.1038/s41540-019-0082-7
Utilizing genome-scale models to optimize nutrient supply for sustained algal growth and lipid productivity.
来源期刊：NPJ systems biology and applicationsDOI：10.1038/s41540-019-0110-7
Mapping connections in signaling networks with ambiguous modularity
来源期刊：NPJ Systems Biology and ApplicationsDOI：10.1038/s41540-019-0096-1
Combinatorial perturbation analysis reveals divergent regulations of mesenchymal genes during epithelial-to-mesenchymal transition
来源期刊：NPJ Systems Biology and ApplicationsDOI：10.1038/s41540-019-0097-0
Multi-dimensional computational pipeline for large-scale deep screening of compound effect assessment: an in silico case study on ageing-related compounds
来源期刊：NPJ Systems Biology and ApplicationsDOI：10.1038/s41540-019-0119-y
Publisher Correction: Multi-experiment nonlinear mixed effect modeling of single-cell translation kinetics after transfection
来源期刊：NPJ Systems Biology and ApplicationsDOI：10.1038/s41540-019-0083-6
Publisher Correction: Mathematical model of hemodynamic mechanisms and consequences of glomerular hypertension in diabetic mice
来源期刊：NPJ Systems Biology and ApplicationsDOI：10.1038/s41540-019-0081-8
An in-silico approach for discovery of microRNA-TF regulation of DISC1 interactome mediating neuronal migration
来源期刊：NPJ Systems Biology and ApplicationsDOI：10.1038/s41540-019-0094-3
Genetic interaction networks mediate individual statin drug response in Saccharomyces cerevisiae
来源期刊：NPJ Systems Biology and ApplicationsDOI：10.1038/s41540-019-0112-5
Hierarchical graphical model reveals HFR1 bridging circadian rhythm and flower development in Arabidopsis thaliana
来源期刊：NPJ Systems Biology and ApplicationsDOI：10.1038/s41540-019-0106-3
Logical design of oral glucose ingestion pattern minimizing blood glucose in humans.
来源期刊：NPJ systems biology and applicationsDOI：10.1038/s41540-019-0108-1
Signal integration and information transfer in an allosterically regulated network
来源期刊：NPJ Systems Biology and ApplicationsDOI：10.1038/s41540-019-0100-9
An unconventional uptake rate objective function approach enhances applicability of genome-scale models for mammalian cells
来源期刊：NPJ Systems Biology and ApplicationsDOI：10.1038/s41540-019-0103-6
An omnidirectional visualization model of personalized gene regulatory networks.
来源期刊：NPJ systems biology and applicationsDOI：10.1038/s41540-019-0116-1
