Signal Transduction and Targeted Therapy (ISSN 2059-3635 (online), ISSN 2095-9907 (print), CN 51-1758/R) is a new open access journal, which aims to accomplish timely publication of the latest discoveries and progress in both basic science and clinical research related to signal transduction and targeted therapy. It will include research on major human diseases, including but not limited to: cancer, cardiovascular diseases, autoimmune diseases, and nervous system diseases.
《信号转导与靶向治疗》（ISSN 2059-3635（在线），ISSN 2095-9907（印刷），CN 51-1758/R）是一本新的开放获取期刊，旨在实现及时发表与信号转导和靶向治疗相关的基础科学和临床研究的最新发现和进展。它将包括对主要人类疾病的研究，包括但不限于：癌症、心血管疾病、自身免疫疾病和神经系统疾病。
Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials
来源期刊：Signal Transduction and Targeted TherapyDOI：10.1038/s41392-019-0095-0
Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles.
来源期刊：Signal transduction and targeted therapyDOI：10.1038/s41392-019-0068-3
History and progress of hypotheses and clinical trials for Alzheimer’s disease
来源期刊：Signal Transduction and Targeted TherapyDOI：10.1038/s41392-019-0063-8
Targeting EGFR exon 20 insertion mutations in non-small cell lung cancer
来源期刊：Signal Transduction and Targeted TherapyDOI：10.1038/s41392-019-0038-9
PROTACs: great opportunities for academia and industry
来源期刊：Signal Transduction and Targeted TherapyDOI：10.1038/s41392-019-0101-6
Targeted therapeutic options and future perspectives for HER2-positive breast cancer
来源期刊：Signal Transduction and Targeted TherapyDOI：10.1038/s41392-019-0069-2
Demystifying the manipulation of host immunity, metabolism, and extraintestinal tumors by the gut microbiome
来源期刊：Signal Transduction and Targeted TherapyDOI：10.1038/s41392-019-0074-5
The roles of exosomal miRNAs and lncRNAs in lung diseases
来源期刊：Signal Transduction and Targeted TherapyDOI：10.1038/s41392-019-0080-7
Targeting growth hormone function: strategies and therapeutic applications
来源期刊：Signal Transduction and Targeted TherapyDOI：10.1038/s41392-019-0036-y
Chemical compound cinobufotalin potently induces FOXO1-stimulated cisplatin sensitivity by antagonizing its binding partner MYH9.
来源期刊：Signal transduction and targeted therapyDOI：10.1038/s41392-019-0084-3
MKP-1 reduces Aβ generation and alleviates cognitive impairments in Alzheimer’s disease models
来源期刊：Signal Transduction and Targeted TherapyDOI：10.1038/s41392-019-0091-4
Local delivery of arsenic trioxide nanoparticles for hepatocellular carcinoma treatment
来源期刊：Signal Transduction and Targeted TherapyDOI：10.1038/s41392-019-0062-9
EGFR TKIs impair lysosome-dependent degradation of SQSTM1 to compromise the effectiveness in lung cancer.
来源期刊：Signal transduction and targeted therapyDOI：10.1038/s41392-019-0059-4
Seryl tRNA synthetase cooperates with POT1 to regulate telomere length and cellular senescence.
来源期刊：Signal transduction and targeted therapyDOI：10.1038/s41392-019-0078-1
The β-catenin/YAP signaling axis is a key regulator of melanoma-associated fibroblasts
来源期刊：Signal Transduction and Targeted TherapyDOI：10.1038/s41392-019-0100-7
Epigenetic drug library screening identified an LSD1 inhibitor to target UTX-deficient cells for differentiation therapy
来源期刊：Signal Transduction and Targeted TherapyDOI：10.1038/s41392-019-0040-2
Off-Targeting of Base Editors: BE3 but not ABE induces substantial off-target single nucleotide variants
来源期刊：Signal Transduction and Targeted TherapyDOI：10.1038/s41392-019-0044-y
Serotonylation: A novel histone H3 marker
来源期刊：Signal Transduction and Targeted TherapyDOI：10.1038/s41392-019-0048-7
Saikosaponin D suppresses enterovirus A71 infection by inhibiting autophagy
来源期刊：Signal Transduction and Targeted TherapyDOI：10.1038/s41392-019-0037-x
PCDH17 increases the sensitivity of colorectal cancer to 5-fluorouracil treatment by inducing apoptosis and autophagic cell death
来源期刊：Signal Transduction and Targeted TherapyDOI：10.1038/s41392-019-0087-0
Tumor-suppressive function and mechanism of HOXB13 in right-sided colon cancer
来源期刊：Signal Transduction and Targeted TherapyDOI：10.1038/s41392-019-0086-1
Clonal replacement of novel T cells: a new phenomenon in the tumor microenvironment following PD-1 blockade
来源期刊：Signal Transduction and Targeted TherapyDOI：10.1038/s41392-019-0077-2
The antimicrobial peptide PFR induces necroptosis mediated by ER stress and elevated cytoplasmic calcium and mitochondrial ROS levels: cooperation with Ara-C to act against acute myeloid leukemia
来源期刊：Signal Transduction and Targeted TherapyDOI：10.1038/s41392-019-0073-6
The proatherosclerotic function of indoleamine 2, 3-dioxygenase 1 in the developmental stage of atherosclerosis
来源期刊：Signal Transduction and Targeted TherapyDOI：10.1038/s41392-019-0058-5
Author Correction: History and progress of hypotheses and clinical trials for Alzheimer’s disease
来源期刊：Signal Transduction and Targeted TherapyDOI：10.1038/s41392-019-0071-8
miR-124/VAMP3 is a novel therapeutic target for mitigation of surgical trauma-induced microglial activation
来源期刊：Signal Transduction and Targeted TherapyDOI：10.1038/s41392-019-0061-x
Dual inhibition of CDK4 and FYN leads to selective cell death in KRAS-mutant colorectal cancer
来源期刊：Signal Transduction and Targeted TherapyDOI：10.1038/s41392-019-0088-z
Genetically engineered T cells for cancer immunotherapy
来源期刊：Signal Transduction and Targeted TherapyDOI：10.1038/s41392-019-0070-9
Structural basis for the acetylation of histone H3K9 and H3K27 mediated by the histone chaperone Vps75 in Pneumocystis carinii
来源期刊：Signal Transduction and Targeted TherapyDOI：10.1038/s41392-019-0047-8
Allelic frequency differences of DAOA variants between Caucasians and Asians and their association with major mood disorders
来源期刊：Signal Transduction and Targeted TherapyDOI：10.1038/s41392-019-0066-5
TGIF2 promotes the progression of lung adenocarcinoma by bridging EGFR/RAS/ERK signaling to cancer cell stemness
来源期刊：Signal Transduction and Targeted TherapyDOI：10.1038/s41392-019-0098-x
Peptides encoded by noncoding genes: challenges and perspectives
来源期刊：Signal Transduction and Targeted TherapyDOI：10.1038/s41392-019-0092-3
Effects of insulin and pathway inhibitors on the PI3K-Akt-mTOR phosphorylation profile in acute myeloid leukemia cells.
来源期刊：Signal transduction and targeted therapyDOI：10.1038/s41392-019-0050-0
The interrelationship between cerebral ischemic stroke and glioma: a comprehensive study of recent reports.
来源期刊：Signal transduction and targeted therapyDOI：10.1038/s41392-019-0075-4
Pazopanib in advanced soft tissue sarcomas.
来源期刊：Signal transduction and targeted therapyDOI：10.1038/s41392-019-0049-6
Global profiling of O-GlcNAcylated and/or phosphorylated proteins in hepatoblastoma.
来源期刊：Signal transduction and targeted therapyDOI：10.1038/s41392-019-0067-4
Coagulation factors: a novel class of endogenous host antimicrobial proteins against drug-resistant gram-negative bacteria
来源期刊：Signal Transduction and Targeted TherapyDOI：10.1038/s41392-019-0083-4
Author Correction: A novel cancer vaccine with the ability to simultaneously produce anti-PD-1 antibody and GM-CSF in cancer cells and enhance Th1-biased antitumor immunity.
来源期刊：Signal transduction and targeted therapyDOI：10.1038/s41392-019-0065-6
Dickkopf-1 contributes to hepatocellular carcinoma tumorigenesis by activating the Wnt/β-catenin signaling pathway
来源期刊：Signal Transduction and Targeted TherapyDOI：10.1038/s41392-019-0082-5
DNA-PKcs promotes alcohol-related liver disease by activating Drp1-related mitochondrial fission and repressing FUNDC1-required mitophagy.
来源期刊：Signal transduction and targeted therapyDOI：10.1038/s41392-019-0094-1
