As the discipline of biochemistry and molecular biology have greatly advanced in the last quarter century, significant contributions have been made towards the advancement of general medicine, genetics, immunology, developmental biology, and biophysics. Investigators in a wide range of disciplines increasingly require an appreciation of the significance of current biochemical and molecular biology advances while, members of the biochemical and molecular biology community itself seek concise information on advances in areas remote from their own specialties.Critical Reviews in Biochemistry and Molecular Biology believes that well-written review articles prove an effective device for the integration and meaningful comprehension of vast, often contradictory, literature. Review articles also provide an opportunity for creative scholarship by synthesizing known facts, fruitful hypotheses, and new concepts. Accordingly, Critical Reviews in Biochemistry and Molecular Biology publishes high-quality reviews that organize, evaluate, and present the current status of high-impact, current issues in the area of biochemistry and molecular biology.Topics are selected on the advice of an advisory board of outstanding scientists, who also suggest authors of special competence. The topics chosen are sufficiently broad to interest a wide audience of readers, yet focused enough to be within the competence of a single author. Authors are chosen based on their activity in the field and their proven ability to produce a well-written publication.
随着生物化学和分子生物学学科在过去的25世纪里取得了巨大的进步,对普通医学、遗传学、免疫学、发育生物学和生物物理学的发展做出了重大贡献。广泛学科的研究者越来越需要了解当前生物化学和分子生物学进展的重要性,生物化学和分子生物学社区的成员本身寻求在远离他们自己的专业领域的进展的简明信息。书面综述文章被证明是整合和有意义地理解大量的、常常相互矛盾的文献的有效手段。综述文章也提供了一个机会,通过综合已知的事实,富有成效的假设,和新的概念,创造性的学术。因此,《生物化学和分子生物学评论》出版高质量的评论,组织、评估和介绍生物化学和分子生物学领域中具有高影响力的当前问题的现状。主题是根据杰出科学家顾问委员会的建议选择的,他们还推荐具有特殊能力的作者。所选的主题足够广泛,足以引起广大读者的兴趣,但又足够集中,在一个作者的能力范围内。作者的选择基于他们在该领域的活动和他们被证明的能力,以产生一个良好的书面出版物。
Proteasomal and lysosomal clearance of faulty secretory proteins: ER-associated degradation (ERAD) and ER-to-lysosome-associated degradation (ERLAD) pathways
来源期刊:Critical Reviews in Biochemistry and Molecular BiologyDOI:10.1080/10409238.2019.1610351
Bacterial ribonucleases and their roles in RNA metabolism
来源期刊:Critical Reviews in Biochemistry and Molecular BiologyDOI:10.1080/10409238.2019.1651816
Epigenetic changes during aging and their reprogramming potential
来源期刊:Critical Reviews in Biochemistry and Molecular BiologyDOI:10.1080/10409238.2019.1570075
Vitamin A and vitamin D regulate the microbial complexity, barrier function, and the mucosal immune responses to ensure intestinal homeostasis
来源期刊:Critical Reviews in Biochemistry and Molecular BiologyDOI:10.1080/10409238.2019.1611734
Inhibition of farnesyl pyrophosphate (FPP) and/or geranylgeranyl pyrophosphate (GGPP) biosynthesis and its implication in the treatment of cancers
来源期刊:Critical Reviews in Biochemistry and Molecular BiologyDOI:10.1080/10409238.2019.1568964
Current insights into the mechanism of mammalian immunoglobulin class switch recombination
来源期刊:Critical Reviews in Biochemistry and Molecular BiologyDOI:10.1080/10409238.2019.1659227
Determinants of nutrient limitation in cancer
来源期刊:Critical Reviews in Biochemistry and Molecular BiologyDOI:10.1080/10409238.2019.1611733
Preserving genome integrity and function: the DNA damage response and histone modifications
来源期刊:Critical Reviews in Biochemistry and Molecular BiologyDOI:10.1080/10409238.2019.1620676
Structural and functional modularity of the U2 snRNP in pre-mRNA splicing
来源期刊:Critical Reviews in Biochemistry and Molecular BiologyDOI:10.1080/10409238.2019.1691497
Feedback to the central dogma: cytoplasmic mRNA decay and transcription are interdependent processes
来源期刊:Critical Reviews in Biochemistry and Molecular BiologyDOI:10.1080/10409238.2019.1679083
Structure and function of eTudor domain containing TDRD proteins
来源期刊:Critical Reviews in Biochemistry and Molecular BiologyDOI:10.1080/10409238.2019.1603199
Ro60 and Y RNAs: structure, functions, and roles in autoimmunity
来源期刊:Critical Reviews in Biochemistry and Molecular BiologyDOI:10.1080/10409238.2019.1608902
A tumor suppressive DNA translocase named FANCM
来源期刊:Critical Reviews in Biochemistry and Molecular BiologyDOI:10.1080/10409238.2019.1568963
TPR-containing proteins control protein organization and homeostasis for the endoplasmic reticulum
来源期刊:Critical Reviews in Biochemistry and Molecular BiologyDOI:10.1080/10409238.2019.1590305
The carboxy-terminus, a key regulator of protein function
来源期刊:Critical Reviews in Biochemistry and Molecular BiologyDOI:10.1080/10409238.2019.1586828
The regulation of chromosome segregation via centromere loops
来源期刊:Critical Reviews in Biochemistry and Molecular BiologyDOI:10.1080/10409238.2019.1670130
Structural aspects of chaperone-mediated peptide loading in the MHC-I antigen presentation pathway
来源期刊:Critical Reviews in Biochemistry and Molecular BiologyDOI:10.1080/10409238.2019.1610352
The role of GDF11 in aging and skeletal muscle, cardiac and bone homeostasis
来源期刊:Critical Reviews in Biochemistry and Molecular BiologyDOI:10.1080/10409238.2019.1610722
The multiscale effects of polycomb mechanisms on 3D chromatin folding
来源期刊:Critical Reviews in Biochemistry and Molecular BiologyDOI:10.1080/10409238.2019.1679082
The ZZ domain as a new epigenetic reader and a degradation signal sensor
来源期刊:Critical Reviews in Biochemistry and Molecular BiologyDOI:10.1080/10409238.2018.1564730
RNA–DNA hybrids and the convergence with DNA repair
来源期刊:Critical Reviews in Biochemistry and Molecular BiologyDOI:10.1080/10409238.2019.1670131
Post-replication repair: Rad5/HLTF regulation, activity on undamaged templates, and relationship to cancer
来源期刊:Critical Reviews in Biochemistry and Molecular BiologyDOI:10.1080/10409238.2019.1651817
Spatiotemporal regulation of PCNA ubiquitination in damage tolerance pathways
来源期刊:Critical Reviews in Biochemistry and Molecular BiologyDOI:10.1080/10409238.2019.1687420
Resistance outside the substrate envelope: hepatitis C NS3/4A protease inhibitors
来源期刊:Critical Reviews in Biochemistry and Molecular BiologyDOI:10.1080/10409238.2019.1568962