Cell Chemical Biology is a Cell Press journal publishing research and review content of exceptional interest for the chemical biology community. Launched in 1994 under the title Chemistry & Biology, the journal was the first to recognize the growing importance of investigations done at the interface of chemistry and biology, and its mission has always been to support and promote chemical biology and conversation and collaboration between chemical and life sciences.Cell Chemical Biology strongly encourages submission of articles that provide significant conceptual advancement of broad general interest to both chemists and biologists. We are especially interested in papers that combine the use of chemical tools to perturb, visualize, and measure biological systems and properties and offer unique insights into molecular mechanism or physiology. We also encourage submissions that are focused on method development for basic life sciences or that have practical impact of either clinical or biotechnological nature. Some additional types of research that we consider within our scope are studies of metabolism and physiology; enzyme mechanism and natural product biosynthesis; generation, distribution, and function of small molecule-protein conjugates such as post-translational modifications; mechanism of resistance to small molecules by viruses/bacteria/cancer cells/organisms; intra- and intercellular and intra- and interspecies communication mediated by small molecules; and chemical biology of lipids, sugars, and nucleic acids. Finally, large-scale studies enabled by the use of chemistry-based technology, such as proteomics, lipidomics, metabolomics, and glycomics, are also within our scope, as well as synthetic and systems biology work when inspired and supported by chemical tools or aimed at engineering biological systems to perform a new type of chemical transformation.
《细胞化学生物学》（Cell Chemical Biology）是一本细胞出版社的期刊，出版的研究和评论内容对化学生物学界有着特殊的意义。该杂志于1994年以《化学与生物学》为题创刊，是第一个认识到化学与生物学相互作用日益重要的研究，其使命一直是支持和促进化学生物学以及化学和生命科学之间的对话和合作。《细胞化学生物学》强烈鼓励提交那些能为化学家和生物学家提供广泛兴趣的重大概念进展的文章。我们特别感兴趣的论文，联合收割机使用化学工具，以干扰，可视化，并测量生物系统和性质，并提供独特的见解，分子机制或生理学。我们还鼓励提交重点关注基础生命科学方法开发或具有临床或生物技术性质的实际影响的申请。我们认为在我们范围内的一些其他类型的研究是代谢和生理学研究;酶作用机制和天然产物生物合成;小分子-蛋白质缀合物的产生、分布和功能，例如翻译后修饰;病毒/细菌/癌细胞/生物体对小分子的抗性机制;小分子介导的细胞内和细胞间以及种内和种间通讯;以及脂类、糖和核酸的化学生物学。最后，通过使用基于化学的技术（如蛋白质组学、脂质组学、代谢组学和糖组学）进行的大规模研究也在我们的范围内，合成和系统生物学工作也在化学工具的启发和支持下进行，或旨在设计生物系统以进行新型化学转化。
Bile Acid 7α-Dehydroxylating Gut Bacteria Secrete Antibiotics that Inhibit Clostridium difficile: Role of Secondary Bile Acids.
来源期刊：Cell chemical biologyDOI：10.1016/j.chembiol.2018.10.003
Multiomics Profiling Establishes the Polypharmacology of FDA-Approved CDK4/6 Inhibitors and the Potential for Differential Clinical Activity.
来源期刊：Cell chemical biologyDOI：10.1016/J.CHEMBIOL.2019.05.005
Stabilization of the Max Homodimer with a Small Molecule Attenuates Myc-Driven Transcription.
来源期刊：Cell chemical biologyDOI：10.1016/j.chembiol.2019.02.009
Development of a Selective CDK7 Covalent Inhibitor Reveals Predominant Cell-Cycle Phenotype.
来源期刊：Cell chemical biologyDOI：10.1016/j.chembiol.2019.02.012
MemBright: A Family of Fluorescent Membrane Probes for Advanced Cellular Imaging and Neuroscience.
来源期刊：Cell chemical biologyDOI：10.1016/j.chembiol.2019.01.009
Labeling Strategies Matter for Super-Resolution Microscopy: A Comparison between HaloTags and SNAP-tags
来源期刊：Cell Chemical BiologyDOI：10.1016/j.chembiol.2019.01.003
Directed Non-targeted Mass Spectrometry and Chemical Networking for Discovery of Eicosanoids and Related Oxylipins.
来源期刊：Cell chemical biologyDOI：10.1016/j.chembiol.2018.11.015
Cheminformatics Tools for Analyzing and Designing Optimized Small-Molecule Collections and Libraries.
来源期刊：Cell chemical biologyDOI：10.1016/j.chembiol.2019.02.018
Stabilization of lncRNA GAS5 by a Small Molecule and Its Implications in Diabetic Adipocytes.
来源期刊：Cell chemical biologyDOI：10.1016/j.chembiol.2018.11.012
Anti-PEG Antibodies Inhibit the Anticoagulant Activity of PEGylated Aptamers.
来源期刊：Cell chemical biologyDOI：10.1016/j.chembiol.2019.02.001
Non-enzymatic Lysine Lactoylation of Glycolytic Enzymes.
来源期刊：Cell chemical biologyDOI：10.1016/j.chembiol.2019.11.005
Phenotypic Screening Combined with Machine Learning for Efficient Identification of Breast Cancer-Selective Therapeutic Targets.
来源期刊：Cell chemical biologyDOI：10.1016/J.CHEMBIOL.2019.03.011
A Soluble Metabolon Synthesizes the Isoprenoid Lipid Ubiquinone.
来源期刊：Cell chemical biologyDOI：10.1016/j.chembiol.2018.12.001
Optogenetic Delineation of Receptor Tyrosine Kinase Subcircuits in PC12 Cell Differentiation.
来源期刊：Cell chemical biologyDOI：10.1016/j.chembiol.2018.11.004
Allosteric Inhibition of Ubiquitin-like Modifications by a Class of Inhibitor of SUMO-Activating Enzyme.
来源期刊：Cell chemical biologyDOI：10.1016/j.chembiol.2018.10.026
Selective Disruption of Mitochondrial Thiol Redox State in Cells and In Vivo
来源期刊：Cell Chemical BiologyDOI：10.1016/j.chembiol.2018.12.002
Unique Binding Specificities of Proteins toward Isomeric Asparagine-Linked Glycans.
来源期刊：Cell chemical biologyDOI：10.1016/j.chembiol.2019.01.002
Discovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling.
来源期刊：Cell chemical biologyDOI：10.1016/j.chembiol.2019.11.014
A Bump-Hole Approach for Directed RNA Editing.
来源期刊：Cell chemical biologyDOI：10.1016/j.chembiol.2018.10.025
From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9.
来源期刊：Cell chemical biologyDOI：10.1016/j.chembiol.2019.10.002
The Pseudo Natural Product Myokinasib Is a Myosin Light Chain Kinase 1 Inhibitor with Unprecedented Chemotype.
来源期刊：Cell chemical biologyDOI：10.1016/j.chembiol.2018.11.014
A Chemical Strategy for Protease Substrate Profiling.
来源期刊：Cell chemical biologyDOI：10.1016/j.chembiol.2019.03.007
What Makes a Kinase Promiscuous for Inhibitors?
来源期刊：Cell chemical biologyDOI：10.1016/j.chembiol.2018.11.005
Detection of Low-Abundance Metabolites in Live Cells Using an RNA Integrator.
来源期刊：Cell chemical biologyDOI：10.1016/j.chembiol.2019.01.005
Antitubercular Triazines: Optimization and Intrabacterial Metabolism.
来源期刊：Cell chemical biologyDOI：10.1016/j.chembiol.2019.10.010
Discovery and Characterization of a Cellular Potent Positive Allosteric Modulator of the Polycomb Repressive Complex 1 Chromodomain, CBX7.
来源期刊：Cell chemical biologyDOI：10.1016/j.chembiol.2019.07.013
Role of Bile in Infectious Disease: the Gall of 7α-Dehydroxylating Gut Bacteria.
来源期刊：Cell chemical biologyDOI：10.1016/j.chembiol.2018.12.010
Complex Formation between VEGFR2 and the β2-Adrenoceptor
来源期刊：Cell Chemical BiologyDOI：10.1016/j.chembiol.2019.02.014
G-quadruplexes Sequester Free Heme in Living Cells.
来源期刊：Cell chemical biologyDOI：10.1016/j.chembiol.2019.10.003
Responsive Antibody Conjugates Enable Quantitative Determination of Intracellular Bond Degradation Rate.
来源期刊：Cell chemical biologyDOI：10.1016/j.chembiol.2019.09.008
Toxic Activation of an AAA+ Protease by the Antibacterial Drug Cyclomarin A.
来源期刊：Cell chemical biologyDOI：10.1016/j.chembiol.2019.05.008
Customizing Functionalized Cofactor Mimics to Study the Human Pyridoxal 5′-Phosphate-Binding Proteome
来源期刊：Cell Chemical BiologyDOI：10.1016/j.chembiol.2019.08.003
Characterization, Dynamics, and Mechanism of CXCR4 Antagonists on a Constitutively Active Mutant.
来源期刊：Cell chemical biologyDOI：10.1016/j.chembiol.2019.01.012
Selection of DNA Cleavage Sites by Topoisomerase II Results from Enzyme-Induced Flexibility of DNA.
来源期刊：Cell chemical biologyDOI：10.1016/j.chembiol.2018.12.003
Plasmodium PK9 Inhibitors Promote Growth of Liver-Stage Parasites.
来源期刊：Cell chemical biologyDOI：10.1016/j.chembiol.2018.11.003
Clofarabine Commandeers the RNR-α-ZRANB3 Nuclear Signaling Axis.
来源期刊：Cell chemical biologyDOI：10.1016/j.chembiol.2019.11.012
Parvifoline AA Promotes Susceptibility of Hepatocarcinoma to Natural Killer Cell-Mediated Cytolysis by Targeting Peroxiredoxin.
来源期刊：Cell chemical biologyDOI：10.1016/j.chembiol.2019.04.003
Membrane-Active Rhamnolipids Overcome Aminoglycoside Resistance.
来源期刊：Cell chemical biologyDOI：10.1016/j.chembiol.2019.09.015
A Strategic Approach for Fluorescence Imaging of Membrane Proteins in a Native-like Environment.
来源期刊：Cell chemical biologyDOI：10.1016/j.chembiol.2019.11.008
Death by Retrograde Transport: Avoiding the Apoptosis Default.
来源期刊：Cell chemical biologyDOI：10.1016/j.chembiol.2019.12.002
Discovery of a First-In-Class Covalent Allosteric Inhibitor of SUMO E1 Activating Enzyme.
来源期刊：Cell chemical biologyDOI：10.1016/j.chembiol.2019.02.006
Identifying Anti-prion Chemical Compounds Using a Newly Established Yeast High-Throughput Screening System.
来源期刊：Cell chemical biologyDOI：10.1016/j.chembiol.2019.10.004
Metabolic Modifier Screen Reveals Secondary Targets of Protein Kinase Inhibitors within Nucleotide Metabolism.
来源期刊：Cell chemical biologyDOI：10.1016/j.chembiol.2019.10.012
Severing Ties: Quantifying the Payload Release from Antibody Drug Conjugates.
来源期刊：Cell chemical biologyDOI：10.1016/j.chembiol.2019.12.001
Protein Chemistry Looking Ahead: 8th Chemical Protein Synthesis Meeting 16-19 June 2019, Berlin, Germany.
来源期刊：Cell chemical biologyDOI：10.1016/j.chembiol.2019.09.011
How Sweet It Is: Small-Molecule Inhibitors of mTORC1 Glucose Sensing.
来源期刊：Cell chemical biologyDOI：10.1016/j.chembiol.2019.09.001
Mechanistic MALDI-TOF Cell-Based Assay for the Discovery of Potent and Specific Fatty Acid Synthase Inhibitors.
来源期刊：Cell chemical biologyDOI：10.1016/j.chembiol.2019.06.004
Probing Substrate Preferences of Depalmitoylases.
来源期刊：Cell chemical biologyDOI：10.1016/j.chembiol.2018.12.008
Interactome Changes Quantified to Identify the ER Proteostasis Network to Fight Amyloid Diseases.
来源期刊：Cell chemical biologyDOI：10.1016/j.chembiol.2019.07.003
Improved ThwaRTing of Genome Symbionts.
来源期刊：Cell chemical biologyDOI：10.1016/j.chembiol.2019.07.014
