Cell Systems is a broad, multidisciplinary monthly journal for outstanding research that provides, supports, or applies systems-level understanding in the life sciences and related disciplines. Manuscripts describing novel discoveries, milestone achievements, broadly useful tools or resources, or insights into the use of technology may all be appropriate. Quantitative integrative studies that reveal general principles of systems are particularly welcome.
细胞系统是一个广泛的,多学科的月刊,为杰出的研究,提供,支持,或应用系统水平的理解在生命科学和相关学科。描述新发现、里程碑式成就、广泛有用的工具或资源或对技术使用的见解的手稿可能都是合适的。揭示系统一般原理的定量综合研究尤其受欢迎。
DoubletFinder: Doublet Detection in Single-Cell RNA Sequencing Data Using Artificial Nearest Neighbors.
来源期刊:Cell systemsDOI:10.1016/j.cels.2019.03.003
End-to-End Differentiable Learning of Protein Structure.
来源期刊:Cell systemsDOI:10.1016/j.cels.2019.03.006
exceRpt: A Comprehensive Analytic Platform for Extracellular RNA Profiling.
来源期刊:Cell systemsDOI:10.1016/j.cels.2019.03.004
A De Novo Shape Motif Discovery Algorithm Reveals Preferences of Transcription Factors for DNA Shape Beyond Sequence Motifs.
来源期刊:Cell systemsDOI:10.1016/j.cels.2018.12.001
High-Resolution Mapping of the Escherichia coli Chromosome Reveals Positions of High and Low Transcription.
来源期刊:Cell systemsDOI:10.1016/j.cels.2019.02.004
Continuum of Gene-Expression Profiles Provides Spatial Division of Labor within a Differentiated Cell Type.
来源期刊:Cell systemsDOI:10.1016/j.cels.2018.12.008
CALDER: Inferring Phylogenetic Trees from Longitudinal Tumor Samples.
来源期刊:Cell systemsDOI:10.1016/j.cels.2019.05.010
Identification of Cancer Drivers at CTCF Insulators in 1,962 Whole Genomes.
来源期刊:Cell systemsDOI:10.1016/j.cels.2019.04.001
Quantification of Uncertainty in Peptide-MHC Binding Prediction Improves High-Affinity Peptide Selection for Therapeutic Design.
来源期刊:Cell systemsDOI:10.1016/j.cels.2019.05.004
Simultaneous Integration of Multi-omics Data Improves the Identification of Cancer Driver Modules.
来源期刊:Cell systemsDOI:10.1016/j.cels.2019.04.005
Neoantigen Dissimilarity to the Self-Proteome Predicts Immunogenicity and Response to Immune Checkpoint Blockade.
来源期刊:Cell systemsDOI:10.1016/j.cels.2019.08.009
Allosteric Feedback Inhibition Enables Robust Amino Acid Biosynthesis in E. coli by Enforcing Enzyme Overabundance
来源期刊:Cell SystemsDOI:10.1016/j.cels.2018.12.005
Higher-Order Interaction between Species Inhibits Bacterial Invasion of a Phototroph-Predator Microbial Community.
来源期刊:Cell systemsDOI:10.1016/j.cels.2019.11.004
Integrated Experimental and Computational Analyses Reveal Differential Metabolic Functionality in Antibiotic-Resistant Pseudomonas aeruginosa.
来源期刊:Cell systemsDOI:10.1016/j.cels.2018.12.002
A Comprehensive Network Atlas Reveals That Turing Patterns Are Common but Not Robust.
来源期刊:Cell systemsDOI:10.1016/j.cels.2019.07.007
tRNA Methylation Is a Global Determinant of Bacterial Multi-drug Resistance.
来源期刊:Cell systemsDOI:10.1016/j.cels.2019.03.008
Genome-Scale Transcriptional Regulatory Network Models of Psychiatric and Neurodegenerative Disorders.
来源期刊:Cell systemsDOI:10.1016/j.cels.2019.01.002
A Scalable, Multiplexed Assay for Decoding GPCR-Ligand Interactions with RNA Sequencing.
来源期刊:Cell systemsDOI:10.1016/j.cels.2019.02.009
Systematic Evaluation of Statistical Methods for Identifying Looping Interactions in 5C Data.
来源期刊:Cell systemsDOI:10.1016/J.CELS.2019.02.006
Adaptation of Human iPSC-Derived Cardiomyocytes to Tyrosine Kinase Inhibitors Reduces Acute Cardiotoxicity via Metabolic Reprogramming.
来源期刊:Cell systemsDOI:10.1016/j.cels.2019.03.009
Single-Cell Analysis Reveals Regulatory Gene Expression Dynamics Leading to Lineage Commitment in Early T Cell Development.
来源期刊:Cell systemsDOI:10.1016/j.cels.2019.09.008
Determination of the Gene Regulatory Network of a Genome-Reduced Bacterium Highlights Alternative Regulation Independent of Transcription Factors
来源期刊:Cell SystemsDOI:10.1016/j.cels.2019.07.001
Hard Limits and Performance Tradeoffs in a Class of Antithetic Integral Feedback Networks.
来源期刊:Cell systemsDOI:10.1016/j.cels.2019.06.001
Decoupling of Rates of Protein Synthesis from Cell Expansion Leads to Supergrowth.
来源期刊:Cell systemsDOI:10.1016/j.cels.2019.10.001
Torin2 Exploits Replication and Checkpoint Vulnerabilities to Cause Death of PI3K-Activated Triple-Negative Breast Cancer Cells.
来源期刊:Cell systemsDOI:10.1016/j.cels.2019.11.001
Automated Design of Pluripotent Stem Cell Self-Organization.
来源期刊:Cell systemsDOI:10.1016/j.cels.2019.10.008
Rapid Inference of Direct Interactions in Large-Scale Ecological Networks from Heterogeneous Microbial Sequencing Data.
来源期刊:Cell systemsDOI:10.1016/j.cels.2019.08.002
Building Containerized Workflows Using the BioDepot-Workflow-Builder.
来源期刊:Cell systemsDOI:10.1016/j.cels.2019.08.007
High-Throughput Assessment of Kinome-wide Activation States
来源期刊:Cell SystemsDOI:10.1016/j.cels.2019.08.005
Mechanical Force Induces Phosphorylation-Mediated Signaling that Underlies Tissue Response and Robustness in Xenopus Embryos.
来源期刊:Cell systemsDOI:10.1016/j.cels.2019.01.006
Highly Combinatorial Genetic Interaction Analysis Reveals a Multi-Drug Transporter Influence Network
来源期刊:Cell systemsDOI:10.1016/j.cels.2019.09.009
A Simple and Flexible Computational Framework for Inferring Sources of Heterogeneity from Single-Cell Dynamics.
来源期刊:Cell systemsDOI:10.1016/j.cels.2018.12.007
Proteogenomic Network Analysis of Context-Specific KRAS Signaling in Mouse-to-Human Cross-Species Translation.
来源期刊:Cell systemsDOI:10.1016/j.cels.2019.07.006
Untangling Aging Using Dynamic, Organism-Level Phenotypic Networks.
来源期刊:Cell systemsDOI:10.1016/j.cels.2019.02.005
Subpopulation Detection and Their Comparative Analysis across Single-Cell Experiments with scPopCorn.
来源期刊:Cell systemsDOI:10.1016/j.cels.2019.05.007
Compression Generated by a 3D Supracellular Actomyosin Cortex Promotes Embryonic Stem Cell Colony Growth and Expression of Nanog and Oct4.
来源期刊:Cell systemsDOI:10.1016/j.cels.2019.05.008
A Computational Framework for Genome-wide Characterization of the Human Disease Landscape.
来源期刊:Cell systemsDOI:10.1016/j.cels.2018.12.010
Defining Higher-Order Interactions in Synthetic Ecology: Lessons from Physics and Quantitative Genetics.
来源期刊:Cell systemsDOI:10.1016/j.cels.2019.11.009
Protein Structure from Experimental Evolution.
来源期刊:Cell systemsDOI:10.1016/j.cels.2019.11.008
The Limited Information Capacity of Cross-Reactive Sensors Drives the Evolutionary Expansion of Signaling.
来源期刊:Cell systemsDOI:10.1016/j.cels.2018.12.006
iSeq 2.0: A Modular and Interchangeable Toolkit for Interaction Screening in Yeast.
来源期刊:Cell systemsDOI:10.1016/j.cels.2019.03.005
Design and Analysis of a Proportional-Integral-Derivative Controller with Biological Molecules.
来源期刊:Cell systemsDOI:10.1016/j.cels.2019.08.010
Proteomics-Based Monitoring of Pathway Activity Reveals that Blocking Diacylglycerol Biosynthesis Rescues from Alpha-Synuclein Toxicity
来源期刊:Cell SystemsDOI:10.1016/j.cels.2019.07.010
Inferring Regulatory Programs Governing Region Specificity of Neuroepithelial Stem Cells during Early Hindbrain and Spinal Cord Development.
来源期刊:Cell systemsDOI:10.1016/j.cels.2019.05.012
Of Gene Expression and Cell Division Time: A Mathematical Framework for Advanced Differential Gene Expression and Data Analysis.
来源期刊:Cell systemsDOI:10.1016/j.cels.2019.07.009
Inferring Leading Interactions in the p53/Mdm2/Mdmx Circuit through Live-Cell Imaging and Modeling.
来源期刊:Cell systemsDOI:10.1016/j.cels.2019.10.010
Mango: Exploratory Data Analysis for Large-Scale Sequencing Datasets.
来源期刊:Cell systemsDOI:10.1016/j.cels.2019.11.002
mountainClimber Identifies Alternative Transcription Start and Polyadenylation Sites in RNA-Seq.
来源期刊:Cell systemsDOI:10.1016/j.cels.2019.07.011
Computing the Statistical Significance of Overlap between Genome Annotations with iStat.
来源期刊:Cell systemsDOI:10.1016/j.cels.2019.05.006
Reporting p Values.
来源期刊:Cell systemsDOI:10.1016/j.cels.2019.03.001