Cancer Immunology Research publishes outstanding original articles reporting major advances in cancer immunology that span the discipline from basic investigations in host-tumor interactions to developmental therapeutics in model systems, early translational studies in patients, and late-stage clinical trials. The journal disseminates knowledge of immunology to the cancer research community, catalyzing cross-disciplinary work that yields a deeper understanding of the host-tumor relationship, more potent cancer treatments, and improved clinical outcomes.Papers are stringently reviewed, and specific topics of interest include endogenous antitumor immunity, tumor-promoting inflammation, cancer antigens, vaccines, antibodies, cellular therapy, cytokines, immune regulation, immune suppression, immunomodulatory effects of cancer treatment, emerging technologies, and clinical investigations. The journal's special features include "Masters of Immunology"—primers by leading immunologists—and "Cancer Immunology at the Crossroads"—perspectives that highlight the intersection of immunology with other areas of cancer research and allied disciplines.
Cancer Immunology Research发表杰出的原创文章，报道癌症免疫学的重大进展，涵盖从宿主-肿瘤相互作用的基础研究到模型系统的发育治疗、患者的早期转化研究和后期临床试验的学科。该杂志向癌症研究界传播免疫学知识，促进跨学科工作，从而更深入地了解宿主与肿瘤的关系、更有效的癌症治疗方法和改善的临床结果。论文经过严格审查，感兴趣的具体主题包括内源性抗肿瘤免疫、促肿瘤炎症、癌抗原、疫苗、抗体、细胞疗法、细胞因子、免疫调节、免疫抑制、癌症治疗的免疫调节作用、新兴技术和临床研究。该杂志的特色包括“免疫学大师”——领先免疫学家的引物——和“十字路口的癌症免疫学”——强调免疫学与其他癌症研究领域和相关学科交叉的观点。
Antibody–Cytokine Fusions: Versatile Products for the Modulation of Anticancer Immunity
来源期刊：Cancer Immunology ResearchDOI：10.1158/2326-6066.CIR-18-0622
Immune Profiling and Quantitative Analysis Decipher the Clinical Role of Immune-Checkpoint Expression in the Tumor Immune Microenvironment of DLBCL
来源期刊：Cancer Immunology ResearchDOI：10.1158/2326-6066.CIR-18-0439
Endogenous CD4+ T Cells Recognize Neoantigens in Lung Cancer Patients, Including Recurrent Oncogenic KRAS and ERBB2 (Her2) Driver Mutations
来源期刊：Cancer Immunology ResearchDOI：10.1158/2326-6066.CIR-18-0402
Accumulation of Tumor-Infiltrating CD49a+ NK Cells Correlates with Poor Prognosis for Human Hepatocellular Carcinoma
来源期刊：Cancer Immunology ResearchDOI：10.1158/2326-6066.CIR-18-0757
Immune-Checkpoint Blockade Opposes CD8+ T-cell Suppression in Human and Murine Cancer
来源期刊：Cancer Immunology ResearchDOI：10.1158/2326-6066.CIR-18-0054
IL2/Anti-IL2 Complex Combined with CTLA-4, But Not PD-1, Blockade Rescues Antitumor NK Cell Function by Regulatory T-cell Modulation
来源期刊：Cancer Immunology ResearchDOI：10.1158/2326-6066.CIR-18-0697
PD-1 and LAG-3 Dominate Checkpoint Receptor–Mediated T-cell Inhibition in Renal Cell Carcinoma
来源期刊：Cancer Immunology ResearchDOI：10.1158/2326-6066.CIR-19-0146
IRF1 Inhibits Antitumor Immunity through the Upregulation of PD-L1 in the Tumor Cell
来源期刊：Cancer Immunology ResearchDOI：10.1158/2326-6066.CIR-18-0711
Cross-talk between Colon Cells and Macrophages Increases ST6GALNAC1 and MUC1-sTn Expression in Ulcerative Colitis and Colitis-Associated Colon Cancer
来源期刊：Cancer Immunology ResearchDOI：10.1158/2326-6066.CIR-19-0514
Anti–PD-1–Induced Pneumonitis Is Associated with Persistent Imaging Abnormalities in Melanoma Patients
来源期刊：Cancer Immunology ResearchDOI：10.1158/2326-6066.CIR-18-0717
SLAMF6 as a Regulator of Exhausted CD8+ T Cells in Cancer
来源期刊：Cancer Immunology ResearchDOI：10.1158/2326-6066.CIR-18-0664
MicroRNAs Affect Complement Regulator Expression and Mitochondrial Activity to Modulate Cell Resistance to Complement-Dependent Cytotoxicity
来源期刊：Cancer Immunology ResearchDOI：10.1158/2326-6066.CIR-18-0818
Abstract IA14: Cell transfer immunotherapy targeting unique somatic mutations in cancer
来源期刊：Cancer immunology researchDOI：10.1158/2326-6074.CRICIMTEATIAACR18-IA14
Abstract A004: HER2 cancer vaccine phase I clinical trial shows clinical benefit in 54% of evaluable patients
来源期刊：Cancer immunology researchDOI：10.1158/2326-6074.CRICIMTEATIAACR18-A004
Abstract A197: The HMG transcription factor TOX induces a transcriptional and epigenetic program of CD8+ T-cell exhaustion in chronic infection and cancer
来源期刊：Cancer immunology researchDOI：10.1158/2326-6074.CRICIMTEATIAACR18-A197
Abstract B057: Enhancing immunotherapy for triple-negative and HER2+ breast cancer using EpCAM aptamer-siRNA mediated gene knockdown
来源期刊：Cancer immunology researchDOI：10.1158/2326-6074.CRICIMTEATIAACR18-B057
Abstract B063: Leveraging gut microbiota networks to impact tumor immunotherapy
来源期刊：Cancer immunology researchDOI：10.1158/2326-6074.CRICIMTEATIAACR18-B063
Abstract B120: TIPE2 regulates apoptosis and autophagy to inhibit tumorigenesis in colon cancer
来源期刊：Cancer immunology researchDOI：10.1158/2326-6074.CRICIMTEATIAACR18-B120
Abstract B048: Proteomic approaches for the identification of druggable protein and epigenetic targets to complement melanoma immunotherapy
来源期刊：Cancer immunology researchDOI：10.1158/2326-6074.CRICIMTEATIAACR18-B048
Abstract A155: Antibody-dependent cancer cell phagocytosis in macrophages induces immune escape by upregulating PD-L1 and IDO
来源期刊：Cancer immunology researchDOI：10.1158/2326-6074.CRICIMTEATIAACR18-A155
Acknowledgment to Reviewers
来源期刊：Cancer Immunology ResearchDOI：10.1158/2326-6066.CIR-7-1-Reviewers
Abstract B030: Predicting the response of uveal melanoma to immunotherapy with MRI assessments
来源期刊：Cancer immunology researchDOI：10.1158/2326-6074.CRICIMTEATIAACR18-B030
Abstract B081: Serum antibody against NY-ESO-1 and XAGE1 predicts clinical responses to anti-PD-1 therapy in non-small cell lung cancer
来源期刊：Cancer immunology researchDOI：10.1158/2326-6074.CRICIMTEATIAACR18-B081
Abstract A143: Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRPα axis and target for immunotherapy
来源期刊：Cancer immunology researchDOI：10.1158/2326-6074.CRICIMTEATIAACR18-A143
Abstract A095: Discovering the immune profiles of a novel antifolate receptor alpha IgE antibody associated with monocyte-mediated antitumor functions
来源期刊：Cancer immunology researchDOI：10.1158/2326-6074.CRICIMTEATIAACR18-A095
Abstract A222: Exploiting mTORC1-independent protein synthesis in Tregs to boost antitumor immune response
来源期刊：Cancer immunology researchDOI：10.1158/2326-6074.CRICIMTEATIAACR18-A222
Abstract B078: Unbiased identification of CD4+ T-cell epitopes using novel MHC-based chimeric receptors
来源期刊：Cancer immunology researchDOI：10.1158/2326-6074.CRICIMTEATIAACR18-B078
Abstract A054: Tumor cell intrinsic factors dictate immune cell infiltration and response to immunotherapy
来源期刊：Cancer immunology researchDOI：10.1158/2326-6074.CRICIMTEATIAACR18-A054
Abstract B071: Validating sequence similarity-driven neoepitope fitness models via immunogenomics on TCGA and multiregional tumor data
来源期刊：Cancer immunology researchDOI：10.1158/2326-6074.CRICIMTEATIAACR18-B071
Abstract A084: Towards combining androgen deprivation and immunotherapy to prevent progression to castration-resistant prostate cancer
来源期刊：Cancer immunology researchDOI：10.1158/2326-6074.CRICIMTEATIAACR18-A084
Abstract A157: Preclinical pharmacokinetic and pharmacodynamic characterization of AB680, a small-molecule CD73 inhibitor for cancer immunotherapy
来源期刊：Cancer immunology researchDOI：10.1158/2326-6074.CRICIMTEATIAACR18-A157
Abstract A158: Delivering type I interferon to dendritic cells empowers tumor eradication and immune combination treatments
来源期刊：Cancer immunology researchDOI：10.1158/2326-6074.CRICIMTEATIAACR18-A158
Abstract B016: Automated ex vivo expansion of low numbers of tumor-reactive T-cells on the CliniMACS Prodigy®
来源期刊：Cancer immunology researchDOI：10.1158/2326-6074.CRICIMTEATIAACR18-B016
Abstract A152: Investigating metabolic basis of neurotoxicity during CAR-T therapies
来源期刊：Cancer immunology researchDOI：10.1158/2326-6074.CRICIMTEATIAACR18-A152
Abstract A147: AO-176, a next-generation anti-CD47 antibody, induces immunogenic cell death
来源期刊：Cancer immunology researchDOI：10.1158/2326-6074.CRICIMTEATIAACR18-A147
Abstract A006: Phase 1 study to evaluate the safety and tolerability of MEDI4736 (durvalumab, durva) + tremelimumab (treme) in patients with advanced solid tumors
来源期刊：Cancer immunology researchDOI：10.1158/2326-6074.CRICIMTEATIAACR18-A006
Abstract B018: Landscape of natural HLA class I ligand peptides of cancer cells
来源期刊：Cancer immunology researchDOI：10.1158/2326-6074.CRICIMTEATIAACR18-B018
Abstract B054: Single-cell analysis illuminates the gradients of immune cell functional states within human melanoma tumors, and facilitates characterization of tumor-reactive T-cells
来源期刊：Cancer immunology researchDOI：10.1158/2326-6074.CRICIMTEATIAACR18-B054
Abstract A114: Omental fat in ovarian cancer induces metabolic and immune alterations
来源期刊：Cancer immunology researchDOI：10.1158/2326-6074.CRICIMTEATIAACR18-A114
Abstract B129: Human endogenous retroviruses as a potential reservoir for T-cell mediated cancer immunotherapy
来源期刊：Cancer immunology researchDOI：10.1158/2326-6074.CRICIMTEATIAACR18-B129
Abstract A024: Identifying a T-cell receptor for immunotherapy against a leukemia-associated self-antigen in an allogeneic setting
来源期刊：Cancer immunology researchDOI：10.1158/2326-6074.CRICIMTEATIAACR18-A024
Abstract B173: G protein coupling signaling as regulators of dendritic cell maintenance and function in immune responses
来源期刊：Cancer immunology researchDOI：10.1158/2326-6074.CRICIMTEATIAACR18-B173
Abstract B006: Gridded tissue profiling strategy with digital spatial profiling for unbiased tissue sampling
来源期刊：Cancer immunology researchDOI：10.1158/2326-6074.CRICIMTEATIAACR18-B006
Abstract B020: T-cell recognition of large T and small T antigen in Merkel cell polyomavirus-associated cancer
来源期刊：Cancer immunology researchDOI：10.1158/2326-6074.CRICIMTEATIAACR18-B020
Abstract A072: Calreticulin exposures by malignant blasts correlate with robust anticancer immunity and improved clinical outcome in AML patients
来源期刊：Cancer immunology researchDOI：10.1158/2326-6074.CRICIMTEATIAACR18-A072
Abstract A135: Combining low-dose chemotherapy with an NK cell-based immunotherapy as a treatment for triple-negative breast cancer
来源期刊：Cancer immunology researchDOI：10.1158/2326-6074.CRICIMTEATIAACR18-A135
Abstract B151: Exploring the induction of immunogenic cell death (ICD) by high-intensity focused ultrasound (HIFU)
来源期刊：Cancer immunology researchDOI：10.1158/2326-6074.CRICIMTEATIAACR18-B151
Abstract A113: Harnessing lymphoid organ neogenesis as a novel prognostic biomarker and therapeutic target
来源期刊：Cancer immunology researchDOI：10.1158/2326-6074.CRICIMTEATIAACR18-A113
Abstract B119: DC-recruiting biomaterial vaccine to enhance antitumor immunity
来源期刊：Cancer immunology researchDOI：10.1158/2326-6074.CRICIMTEATIAACR18-B119
Abstract B156: Characterization and role of CCR8+ regulatory T-cells in mouse models of malignant melanoma
来源期刊：Cancer immunology researchDOI：10.1158/2326-6074.CRICIMTEATIAACR18-B156
