Aging & Disease (A&D) is a peer reviewed, open access online journal that aspires to publish novel and high-impact findings on central issues pertaining to the biology of aging, pathophysiology of age-related diseases, and innovative therapies for diseases afflicting the elderly population. The diseases of interest include (but not limited to) Stroke, Alzheimer's disease, Parkinson’s disease, Epilepsy, Dementia, Depression, Cardiovascular Disease, Cancer, Arthritis, Cataract, Osteoporosis, Diabetes and Hypertension. Studies on animal models as well as human tissues or cells are welcome.
《衰老与疾病》（A&D）是一本同行评审、开放获取的在线期刊，致力于发表关于衰老生物学、年龄相关疾病的病理生理学以及困扰老年人疾病的创新疗法等核心问题的新颖和高影响力的发现。感兴趣的疾病包括（但不限于）中风、阿尔茨海默病、帕金森病、癫痫、痴呆、抑郁症、心血管疾病、癌症、关节炎、白内障、骨质疏松、糖尿病和高血压。动物模型以及人体组织或细胞的研究是受欢迎的。
Redefining Chronic Inflammation in Aging and Age-Related Diseases: Proposal of the Senoinflammation Concept
来源期刊：Aging and DiseaseDOI：10.14336/AD.2018.0324
Elevated Inflammatory Status and Increased Risk of Chronic Disease in Chronological Aging: Inflamm-aging or Inflamm-inactivity?
来源期刊：Aging and DiseaseDOI：10.14336/AD.2018.0326
Pyroptosis in Liver Disease: New Insights into Disease Mechanisms
来源期刊：Aging and DiseaseDOI：10.14336/AD.2019.0116
Significance of Complement System in Ischemic Stroke: A Comprehensive Review
来源期刊：Aging and DiseaseDOI：10.14336/AD.2019.0119
MicroRNAs or Long Noncoding RNAs in Diagnosis and Prognosis of Coronary Artery Disease
来源期刊：Aging and DiseaseDOI：10.14336/AD.2018.0617
Necrostatin-1 Prevents Necroptosis in Brains after Ischemic Stroke via Inhibition of RIPK1-Mediated RIPK3/MLKL Signaling
来源期刊：Aging and DiseaseDOI：10.14336/AD.2018.0728
Increased Inflammatory Response in Old Mice is Associated with More Severe Neuronal Injury at the Acute Stage of Ischemic Stroke
来源期刊：Aging and DiseaseDOI：10.14336/AD.2018.0205
Emerging Roles of Complement Protein C1q in Neurodegeneration
来源期刊：Aging and DiseaseDOI：10.14336/AD.2019.0118
The Role of Pathological Aging in Cardiac and Pulmonary Fibrosis
来源期刊：Aging and DiseaseDOI：10.14336/AD.2018.0601
Prospective Views for Whey Protein and/or Resistance Training Against Age-related Sarcopenia
来源期刊：Aging and DiseaseDOI：10.14336/AD.2018.0325
Epigenetic Regulation of Bone Marrow Stem Cell Aging: Revealing Epigenetic Signatures associated with Hematopoietic and Mesenchymal Stem Cell Aging
来源期刊：Aging and DiseaseDOI：10.14336/AD.2017.1213
Novel Insights on Systemic and Brain Aging, Stroke, Amyotrophic Lateral Sclerosis, and Alzheimer’s Disease
来源期刊：Aging and DiseaseDOI：10.14336/AD.2019.0330
Subtyping of Parkinson’s Disease - Where Are We Up To?
来源期刊：Aging and DiseaseDOI：10.14336/AD.2019.0112
Aging and End Stage Renal Disease Cause A Decrease in Absolute Circulating Lymphocyte Counts with A Shift to A Memory Profile and Diverge in Treg Population
来源期刊：Aging and DiseaseDOI：10.14336/AD.2018.0318
Health and Aging: Unifying Concepts, Scores, Biomarkers and Pathways
来源期刊：Aging and DiseaseDOI：10.14336/AD.2018.1030
The WNK-SPAK/OSR1 Kinases and the Cation-Chloride Cotransporters as Therapeutic Targets for Neurological Diseases
来源期刊：Aging and DiseaseDOI：10.14336/AD.2018.0928
Involvement of the MiR-181b-5p/HMGB1 Pathway in Ang II-induced Phenotypic Transformation of Smooth Muscle Cells in Hypertension
来源期刊：Aging and DiseaseDOI：10.14336/AD.2018.0510
A Model of Chronic Temporal Lobe Epilepsy Presenting Constantly Rhythmic and Robust Spontaneous Seizures, Co-morbidities and Hippocampal Neuropathology
来源期刊：Aging and DiseaseDOI：10.14336/AD.2019.0720
Collagen XIX Alpha 1 Improves Prognosis in Amyotrophic Lateral Sclerosis
来源期刊：Aging and DiseaseDOI：10.14336/AD.2018.0917
Enhancement of Mesenchymal Stem Cell-Driven Bone Regeneration by Resveratrol-Mediated SOX2 Regulation
来源期刊：Aging and DiseaseDOI：10.14336/AD.2018.0802
Adipose-derived Stem Cells Attenuates Diabetic Osteoarthritis via Inhibition of Glycation-mediated Inflammatory Cascade
来源期刊：Aging and DiseaseDOI：10.14336/AD.2018.0616
Chronic Kidney Disease Is Linked to Carotid Nodular Calcification, An Unstable Plaque Not Correlated to Inflammation
来源期刊：Aging and DiseaseDOI：10.14336/AD.2018.0117
Role of Regulatory T cells in Atorvastatin Induced Absorption of Chronic Subdural Hematoma in Rats
来源期刊：Aging and DiseaseDOI：10.14336/AD.2018.0926
Dl-3-n-butylphthalide Reduces Neurovascular Inflammation and Ischemic Brain Injury in Mice
来源期刊：Aging and DiseaseDOI：10.14336/AD.2019.0608
A Microcirculatory Theory of Aging
来源期刊：Aging and DiseaseDOI：10.14336/AD.2019.0315
Intensive Lipid-Lowering Therapy Ameliorates Asymptomatic Intracranial Atherosclerosis
来源期刊：Aging and DiseaseDOI：10.14336/AD.2018.0526
Calcitriol Analogues Decrease Lung Metastasis but Impair Bone Metabolism in Aged Ovariectomized Mice Bearing 4T1 Mammary Gland Tumours
来源期刊：Aging and DiseaseDOI：10.14336/AD.2018.0921
Efficacy and Safety of the Pneumococcal Conjugate-13 Valent Vaccine in Adults
来源期刊：Aging and DiseaseDOI：10.14336/AD.2018.0512
Quantitative Evaluation of Gait Disturbance on an Instrumented Timed Up-and-go Test
来源期刊：Aging and DiseaseDOI：10.14336/AD.2018.0426
Distribution Pattern of Atherosclerotic Stenosis in Chinese Patients with Stroke: A Multicenter Registry Study
来源期刊：Aging and DiseaseDOI：10.14336/AD.2018.0602
Subclinical Hypothyroidism: is it Really Subclinical with Aging?
来源期刊：Aging and DiseaseDOI：10.14336/AD.2018.0817
Handgrip Strength and Pulmonary Disease in the Elderly: What is the Link?
来源期刊：Aging and DiseaseDOI：10.14336/AD.2018.1226
Hydroxyurea Facilitates Manifestation of Disease Relevant Phenotypes in Patients-Derived IPSCs-Based Modeling of Late-Onset Parkinson’s Disease
来源期刊：Aging and DiseaseDOI：10.14336/AD.2018.1216
Preclinical Evidence and Possible Mechanisms of Extracts or Compounds from Cistanches for Alzheimer’s Disease
来源期刊：Aging and DiseaseDOI：10.14336/AD.2018.0815-1
Autoantibodies against AT1 Receptor Contribute to Vascular Aging and Endothelial Cell Senescence
来源期刊：Aging and DiseaseDOI：10.14336/AD.2018.0919
Clinical and Genetic Profiles in Chinese Patients with Huntington’s Disease: A Ten-year Multicenter Study in China
来源期刊：Aging and DiseaseDOI：10.14336/AD.2018.0911
Relationship between Hypothyroidism and Endometrial Cancer
来源期刊：Aging and DiseaseDOI：10.14336/AD.2018.0224
Galectin-3 Mediates Endothelial-to-Mesenchymal Transition in Pulmonary Arterial Hypertension
来源期刊：Aging and DiseaseDOI：10.14336/AD.2018.1001
Reduction in IGF1 mRNA in the Human Subependymal Zone During Aging
来源期刊：Aging and DiseaseDOI：10.14336/AD.2018.0317
DRAM is Involved in Hypoxia/Ischemia-Induced Autophagic Apoptosis in Hepatocytes
来源期刊：Aging and DiseaseDOI：10.14336/AD.2018.0210
The Peptide-Directed Lysosomal Degradation of CDK5 Exerts Therapeutic Effects against Stroke
来源期刊：Aging and DiseaseDOI：10.14336/AD.2018.1225
Increased Serum C-reactive Protein and Corpus Callosum Alterations in Older Adults
来源期刊：Aging and DiseaseDOI：10.14336/AD.2018.0329
Total Burden of Cerebral Small Vessel Disease in Recurrent ICH versus First-ever ICH
来源期刊：Aging and DiseaseDOI：10.14336/AD.2018.0804
Increased Serum Matrix Metalloproteinase-9 Levels are Associated with Anti-Jo1 but not Anti-MDA5 in Myositis Patients
来源期刊：Aging and DiseaseDOI：10.14336/AD.2018.1120
The Neuronal Activation of Deep Cerebellar Nuclei Is Essential for Environmental Enrichment-Induced Post-Stroke Motor Recovery
来源期刊：Aging and DiseaseDOI：10.14336/AD.2018.1220
Neurological Manifestation of Incretin-Based Therapies in Patients with Type 2 Diabetes: A Systematic Review and Network Meta-Analysis
来源期刊：Aging and DiseaseDOI：10.14336/AD.2019.0303
Longevity Effect of Liuwei Dihuang in Both Caenorhabditis Elegans and Aged Mice
来源期刊：Aging and DiseaseDOI：10.14336/AD.2018.0604
REST rs3796529 Genotype and Rate of Functional Deterioration in Alzheimer’s Disease
来源期刊：Aging and DiseaseDOI：10.14336/AD.2018.0116
Age as an Independent Risk Factor for Diabetic Peripheral Neuropathy in Chinese Patients with Type 2 Diabetes
来源期刊：Aging and DiseaseDOI：10.14336/AD.2018.0618
Genetic Spectrum and Variability in Chinese Patients with Amyotrophic Lateral Sclerosis
来源期刊：Aging and DiseaseDOI：10.14336/AD.2019.0215
