Advanced molecular research techniques have transformed hematology in recent years. With improved understanding of hematologic diseases, we now have the opportunity to research and evaluate new biological therapies, new drugs and drug combinations, new treatment schedules and novel approaches including stem cell transplantation. We can also expect proteomics, molecular genetics and biomarker research to facilitate new diagnostic approaches and the identification of appropriate therapies. Further advances in our knowledge regarding the formation and function of blood cells and blood-forming tissues should ensue, and it will be a major challenge for hematologists to adopt these new paradigms and develop integrated strategies to define the best possible patient care. Expert Review of Hematology (1747-4086) puts these advances in context and explores how they will translate directly into clinical practice.
血液学专家评审近年来,先进的分子研究技术已经改变了血液学。随着对血液病认识的提高,我们现在有机会研究和评估新的生物疗法、新的药物和药物组合、新的治疗方案和新的方法,包括干细胞移植。我们还可以期待蛋白质组学、分子遗传学和生物标志物研究促进新的诊断方法和适当疗法的确定。我们对血细胞和造血组织的形成和功能的认识将继续取得进一步的进展,对血液学家来说,采用这些新的范式并制定综合策略来定义最佳的患者护理将是一个重大挑战。《血液学专家评论》(1747-4086)将这些进展置于背景中,并探讨了它们将如何直接转化为临床实践。
High-dose intravenous immunoglobulin for the treatment and prevention of heparin-induced thrombocytopenia: a review
来源期刊:Expert Review of HematologyDOI:10.1080/17474086.2019.1636645
An update on the biology and management of dyskeratosis congenita and related telomere biology disorders
来源期刊:Expert Review of HematologyDOI:10.1080/17474086.2019.1662720
CXCR4 mutations affect presentation and outcomes in patients with Waldenström macroglobulinemia: A systematic review
来源期刊:Expert Review of HematologyDOI:10.1080/17474086.2019.1649132
Platelet function assays in diagnosis: an update
来源期刊:Expert Review of HematologyDOI:10.1080/17474086.2019.1562333
Overcoming challenges of venous thromboembolism in sickle cell disease treatment
来源期刊:Expert Review of HematologyDOI:10.1080/17474086.2019.1583554
Hematopoietic stem cell transplant with HLA-mismatched grafts: impact of donor, source, conditioning, and graft versus host disease prophylaxis
来源期刊:Expert Review of HematologyDOI:10.1080/17474086.2019.1562331
Considering the spleen in sickle cell disease
来源期刊:Expert Review of HematologyDOI:10.1080/17474086.2019.1627192
A systematic literature review of incidence, mortality, and relapse of patients diagnosed with chronic graft versus host disease
来源期刊:Expert Review of HematologyDOI:10.1080/17474086.2019.1605288
Risk factors, management and prevention of transfusion-related acute lung injury: a comprehensive update
来源期刊:Expert Review of HematologyDOI:10.1080/17474086.2019.1640599
The role of regulatory T cells in graft-versus-host disease management
来源期刊:Expert Review of HematologyDOI:10.1080/17474086.2020.1709436
Genetic mutations in chronic lymphocytic leukemia: impact on clinical treatment
来源期刊:Expert Review of HematologyDOI:10.1080/17474086.2019.1575130
The role of the thrombopoietin receptor MPL in myeloproliferative neoplasms: recent findings and potential therapeutic applications
来源期刊:Expert Review of HematologyDOI:10.1080/17474086.2019.1617129
Molecular genetics in allogeneic blood stem cell transplantation for myelodysplastic syndromes
来源期刊:Expert Review of HematologyDOI:10.1080/17474086.2019.1645004
What should we tackle next in acute myeloid leukemia? Wilms tumor gene 1 vaccine therapy would be a promising and versatile strategy for acute myeloid leukemia
来源期刊:Expert Review of HematologyDOI:10.1080/17474086.2019.1593824
Humanistic burden of patients with chronic graft-versus-host disease - systematic literature review of health-related quality of life and functional status
来源期刊:Expert Review of HematologyDOI:10.1080/17474086.2019.1602036
Novel therapies in low- and high-risk myelodysplastic syndrome
来源期刊:Expert Review of HematologyDOI:10.1080/17474086.2019.1647778
Quality of life in multiple myeloma: considerations and recommendations
来源期刊:Expert Review of HematologyDOI:10.1080/17474086.2019.1613886
Management of antithrombin deficiency: an update for clinicians
来源期刊:Expert Review of HematologyDOI:10.1080/17474086.2019.1611424
Switching patients in the age of long-acting recombinant products?
来源期刊:Expert Review of HematologyDOI:10.1080/17474086.2018.1564032
Management of aplastic anemia after failure of frontline immunosuppression
来源期刊:Expert Review of HematologyDOI:10.1080/17474086.2019.1645003
An update on: molecular genetics of high-risk chronic lymphocytic leukemia
来源期刊:Expert Review of HematologyDOI:10.1080/17474086.2020.1697225
Novel agents may positively impact chemotherapy and transplantation in subsets of diffuse large B-cell lymphoma
来源期刊:Expert Review of HematologyDOI:10.1080/17474086.2019.1596793
Therapeutic potential of PI3K signaling in distinct entities of B-cell lymphoma
来源期刊:Expert Review of HematologyDOI:10.1080/17474086.2019.1676716
Eptacog beta: a novel recombinant human factor VIIa for the treatment of hemophilia A and B with inhibitors
来源期刊:Expert Review of HematologyDOI:10.1080/17474086.2019.1560259
Current and emerging treatments for immune thrombocytopenia
来源期刊:Expert Review of HematologyDOI:10.1080/17474086.2019.1636644
Cyclosporine for angioimmunoblastic T-cell lymphoma: a literature review
来源期刊:Expert Review of HematologyDOI:10.1080/17474086.2019.1652590
Developments in the use of plasma exchange and adjunctive therapies to treat immune-mediated thrombotic thrombocytopenic purpura
来源期刊:Expert Review of HematologyDOI:10.1080/17474086.2019.1619170
Emicizumab for hemophilia A without inhibitors
来源期刊:Expert Review of HematologyDOI:10.1080/17474086.2019.1624519
Contemporary management of essential thrombocythemia in children
来源期刊:Expert Review of HematologyDOI:10.1080/17474086.2019.1602034
Recent advances in the diagnosis and treatment of natural killer/T-cell lymphomas
来源期刊:Expert Review of HematologyDOI:10.1080/17474086.2019.1660640
Improving fibrinolysis in venous thromboembolism: impact of fibrin structure
来源期刊:Expert Review of HematologyDOI:10.1080/17474086.2019.1627193
Timing treatment for smoldering myeloma: is earlier better?
来源期刊:Expert Review of HematologyDOI:10.1080/17474086.2019.1599281
Aggressive Non-Hodgkin lymphomas: risk factors and treatment of central nervous system recurrence
来源期刊:Expert Review of HematologyDOI:10.1080/17474086.2019.1643232
Clinical impact of the cell-of-origin classification based on immunohistochemistry criteria and Lymph2Cx of diffuse large B-Cell lymphoma patients in a South-east Asian population: a single center experience and review of the literature
来源期刊:Expert Review of HematologyDOI:10.1080/17474086.2019.1677152
Moxetumomab pasudotox for the treatment of relapsed and/or refractory hairy cell leukemia
来源期刊:Expert Review of HematologyDOI:10.1080/17474086.2019.1643231
When to use stem cell transplant in mantle cell lymphoma
来源期刊:Expert Review of HematologyDOI:10.1080/17474086.2019.1588106
Time for patient reported outcomes assessment in routine hematology practice: the case of chronic myeloid leukemia
来源期刊:Expert Review of HematologyDOI:10.1080/17474086.2019.1547189
Pharmacokinetic and safety considerations when switching from standard to extended half-life clotting factor concentrates in hemophilia
来源期刊:Expert Review of HematologyDOI:10.1080/17474086.2019.1645002
Tranexamic acid for childbirth: why, when, and for whom
来源期刊:Expert Review of HematologyDOI:10.1080/17474086.2019.1642744
Umbilical cord blood transplantation and the impact of the CTLA4 genotype on outcomes
来源期刊:Expert Review of HematologyDOI:10.1080/17474086.2019.1680281
BRAF in the cross-hairs
来源期刊:Expert Review of HematologyDOI:10.1080/17474086.2019.1583553
Histological transformation in malignant lymphoma: a possible role of PET/CT and circulating tumor DNA as noninvasive diagnostic tools
来源期刊:Expert Review of HematologyDOI:10.1080/17474086.2020.1690987
An update on treatment of higher risk myelodysplastic syndromes
来源期刊:Expert Review of HematologyDOI:10.1080/17474086.2018.1537777
What are the implications of cost for myeloma therapy?
来源期刊:Expert Review of HematologyDOI:10.1080/17474086.2019.1682545
An alternative way – tyrosine kinase inhibitor (TKI) de-escalation – to discontinue TKIs in order to achieve treatment-free remission
来源期刊:Expert Review of HematologyDOI:10.1080/17474086.2019.1623666
An evaluation of brentuximab vedotin as a treatment option for stage III/IV Hodgkin lymphoma
来源期刊:Expert Review of HematologyDOI:10.1080/17474086.2019.1658522
Current perspectives on the treatment of double hit lymphoma
来源期刊:Expert Review of HematologyDOI:10.1080/17474086.2019.1623020
Blinatumomab: a novel therapy for the treatment of non-Hodgkin’s lymphoma
来源期刊:Expert Review of HematologyDOI:10.1080/17474086.2019.1676717
Myelofibrosis: best practices, controversies and 2019 update
来源期刊:Expert Review of HematologyDOI:10.1080/17474086.2020.1691519
Unraveling innovation potential in the real-world setting: eighteen novel agents with twenty-six approved European indications, in the management of leukemias, lymphomas, and multiple myeloma
来源期刊:Expert Review of HematologyDOI:10.1080/17474086.2019.1668763