Organic Process Research & Development 是化学工业界和学术界沟通的桥梁。正因为如此,它不仅报道工业过程化学领域的原创性工作,还介绍与工业应用相关或潜在相关的学术成果。过程化学是一门能够安全、无污染并最终经济地制造出大量有机化合物的科学,以帮助解决社会的需求。因此,本刊涵盖了有机化学的各个方面,包括催化、合成方法学开发和合成策略探索的所有方面,但也包括分析和固态化学以及化学工程的各个方面,如检测手段、过程安全和流动化学。化学反应开发与优化的目标就是能量产;介绍这类研究和实际规模实施的原创性研究与本刊高度相关。然而,那些来自企业、研究所或学术界的新研究,尚未能实现规模生产,但预期有工业化的潜质,或能解决工业化过程中的重大问题,或对其可靠性和实用性充满了信心的研究,本刊也会予以考虑。The journal Organic Process Research & Development serves as a communication tool between industrial chemists and chemists working in universities and research institutes. As such, it reports original work from the broad field of industrial process chemistry but also presents academic results that are relevant, or potentially relevant, to industrial applications. Process chemistry is the science that enables the safe, environmentally benign and ultimately economical manufacturing of organic compounds that are required in larger amounts to help address the needs of society. Consequently, the Journal encompasses every aspect of organic chemistry, including all aspects of catalysis, synthetic methodology development and synthetic strategy exploration, but also includes aspects from analytical and solid-state chemistry and chemical engineering, such as work-up tools,process safety, or flow-chemistry. The goal of development and optimization of chemical reactions and processes is their transfer to a larger scale; original work describing such studies and the actual implementation on scale is highly relevant to the journal. However, studies on new developments from either industry, research institutes or academia that have not yet been demonstrated on scale, but where an industrial utility can be expected and where the study has addressed important prerequisites for a scale-up and has given confidence into the reliability and practicality of the chemistry, also serve the mission of OPR&D as a communication tool between the different contributors to the field.The Journal aims to cover R&D from and for the fine organic chemicals and specialty chemicals industries, including pharmaceuticals, agrochemicals, electronic chemicals, flavors and fragrances, intermediates, food additives, and specialty polymers, with work from commodity chemicals, petrochemicals, and polymers being appropriate as well.
《有机过程研究与开发》杂志是工业化学家与大学和研究机构化学家之间的交流工具。因此,它报告了来自工业过程化学广泛领域的原创工作,但也提出了与工业应用相关或潜在相关的学术成果。过程化学是一门能够安全、环保和最终经济地生产有机化合物的科学,这些有机化合物需要大量生产,以满足社会的需求。因此,该杂志涵盖了有机化学的各个方面,包括催化、合成方法开发和合成策略探索的所有方面,但也包括分析和固态化学以及化学工程的各个方面,如后处理工具、工艺安全或流动化学。化学反应和工艺的开发和优化的目标是将其转移到更大的规模;描述这类研究和实际规模实施的原创性工作与该杂志高度相关。然而,对工业、研究机构或学术界尚未进行规模示范的新发展的研究,但可以预期其具有工业效用,并且该研究已经解决了扩大规模的重要先决条件,并对化学的可靠性和实用性给予了信心,这些研究也为OPR&D的使命服务,作为该领域不同贡献者之间的沟通工具。
The Evolution of High-Throughput Experimentation in Pharmaceutical Development and Perspectives on the Future
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/acs.oprd.9b00140
Batch and Continuous Flow Production of 5-Hydroxymethylfurfural from a High Concentration of Fructose Using an Acidic Ion Exchange Catalyst
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/ACS.OPRD.9B00044
Continuous Flow Chemo-Enzymatic Baeyer–Villiger Oxidation with Superactive and Extra-Stable Enzyme/Carbon Nanotube Catalyst: An Efficient Upgrade from Batch to Flow
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/ACS.OPRD.9B00132
Reactive Crystallization of Paracetamol in a Continuous Oscillatory Baffled Reactor
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/ACS.OPRD.8B00446
Basic Anion-Exchange Resin-Catalyzed Aldol Condensation of Aromatic Ketones with Aldehydes in Continuous Flow
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/ACS.OPRD.9B00048
H–D Exchange Deuteration of Arenes at Room Temperature
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/ACS.OPRD.8B00383
Improved Understanding of Cefixime Trihydrate Reactive Crystallization and Process Scale-up with the Aid of PAT
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/ACS.OPRD.8B00190
A Novel Water-Dispersible/Magnetically Recyclable Pd Catalyst for C–C Cross-Coupling Reactions in Pure Water
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/ACS.OPRD.8B00426
A Comparative Evaluation of Hydrogenation of 3-Butyn-2-ol over Pd/Al2O3 in an Oscillatory Baffled Reactor and a Commercial Parr Reactor
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/ACS.OPRD.8B00324
Development of an Effective Scalable Enantioselective Synthesis of the HIV-1 Entry Inhibitor BNM-III-170 as the Bis-Trifluoroacetate Salt.
来源期刊:Organic process research & developmentDOI:10.1021/acs.oprd.9b00353
Oxidative Cleavage of Long-Chain Terminal Alkenes to Carboxylic Acids
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/ACS.OPRD.8B00368
Concise Synthesis of a Potential 5-Lipoxygenase Activating Protein (FLAP) Inhibitor and Its Analogs through Late-Stage Alkene Dicarbofunctionalization
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/ACS.OPRD.9B00199
Development of Continuous Filtration in a Novel Continuous Filtration Carousel Integrated with Continuous Crystallization
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/acs.oprd.9b00342
Scalable Wolff–Kishner Reductions in Extreme Process Windows Using a Silicon Carbide Flow Reactor
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/acs.oprd.9b00336
FROM MEASUREMENTS TO STANDARDISED MULTI-DOMAIN COMPACT MODELS OF LEDS USING LED E-DATASHEETS
来源期刊:Organic Process Research & DevelopmentDOI:10.25039/X46.2019.OP52
Application of Thiol-Modified Dual-Pore Silica Beads as a Practical Scavenger of Leached Palladium Catalyst in C–C Coupling Reactions
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/ACS.OPRD.8B00291
APPROACH TO ANALYSE SEASONAL AND GEOGRAPHICAL VARIATIONS IN DAYLIGHT ILLUMINANTS
来源期刊:Organic Process Research & DevelopmentDOI:10.25039/X46.2019.OP31
Development of a Scalable Synthesis for the Potent Kinase Inhibitor BMS-986236; 1-(5-(4-(3-Hydroxy-3-methylbutyl)-1H-1,2,3-triazol-1-yl)-4-(isopropylamino)pyridin-2-yl)-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/ACS.OPRD.9B00023
Ammonium Salt-Accelerated Hydrazinolysis of Unactivated Amides: Mechanistic Investigation and Application to a Microwave Flow Process
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/ACS.OPRD.8B00424
Systematic Optimization of a Robust Telescoped Process for a BTK Inhibitor with Atropisomer Control by High-Throughput Experimentation, Design of Experiments, and Linear Regression
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/ACS.OPRD.8B00398
Diffusion-Enhanced Amide Bond Formation on a Solid Support
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/acs.oprd.9b00398
Assessment of Breast Cancer Treatment Outcome at Tikur Anbessa Specialized Hospital Adult Oncology Unit, Addis Ababa, Ethiopia
来源期刊:Organic Process Research & DevelopmentDOI:10.1097/OP9.0000000000000013
Palladium-Catalyzed Synthesis of Deuterated Alkenes through Deuterodechlorination of Alkenyl Chlorides
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/ACS.OPRD.9B00193
A Practical and Robust Multistep Continuous Processfor Manufacturing 5‑Bromo‑ N ‑( tert -butyl)pyridine-3-sulfonamide
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/acs.oprd.9b00254
Development and Implementation of a Quality Control Strategy for an Atropisomer Impurity Grounded in a Risk-Based Probabilistic Design Space
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/ACS.OPRD.8B00293
Development of an Efficient and Scalable Biocatalytic Route to (1S,4R)-8-Hydroxy-1,2,3,4- tetrahydro-1,4-methanonaphthalen-5-yl Propionate via Enantioselective Enzymatic Desymmetrization of a Prochiral Diester
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/ACS.OPRD.9B00188
Development of a Scalable Process for the Insecticidal Candidate Tyclopyrazoflor. Part 1. Evaluation of [3 + 2] Cyclization Strategies to 3-(3-Chloro-1H-pyrazol-1-yl)pyridine
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/ACS.OPRD.9B00127
Energy saving potential for integrated daylighting and electric lighting design via user-driven solutions: A literature review.
来源期刊:Organic Process Research & DevelopmentDOI:10.25039/X46.2019.OP32
Polymorph Control in MSMPR Crystallizers. A Case Study with Paracetamol
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/ACS.OPRD.8B00351
A Holistic Approach to Streamlining Pharmaceutical Processes: A Conversation
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/acs.oprd.8b00440
Development of an Efficient Manufacturing Process for E2212 toward Rapid Clinical Introduction
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/ACS.OPRD.8B00444
Anion Metathesis of Diaryliodonium Tosylate Salts with a Solid-Phase Column Constructed from Readily Available Laboratory Consumables
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/ACS.OPRD.9B00163
Multikilogram-Scale Preparation of AZD4635 via C–H Borylation and Bromination: The Corrosion of Tantalum by a Bromine/Methanol Mixture
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/ACS.OPRD.8B00342
SEMANTIC INTERPRETATION OF THE CIE 2017 COLOUR FIDELITY INDEX
来源期刊:Organic Process Research & DevelopmentDOI:10.25039/X46.2019.OP37
Structural Correction and Process Improvement for Control of a Critical Process Impurity of Ezetimibe
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/ACS.OPRD.9B00024
Numerical and Experimental Quantification of the Performance of Microreactors for Scaling-up Fast Chemical Reactions
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/ACS.OPRD.8B00356
Further Optimization of a Scalable Biocatalytic Route to (3R)-N-Boc-3-aminoazepane with Immobilized ω-Transaminase
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/ACS.OPRD.8B00411
The Destiny of Palladium: Development of Efficient Palladium Analysis Techniques in Enhancing Palladium Recovery
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/ACS.OPRD.9B00204
Improved Manufacturing Route and Polymorphic Control of a Potent and Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor ASP3026
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/ACS.OPRD.8B00427
Synergistic Solvation Effects: Enhanced Compound Solubility Using Binary Solvent Mixtures
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/ACS.OPRD.9B00077
LUMINOUS INTENSITY COMPARISON BASED ON NEW STANDARD LAMPS WITH LED REFERENCE SPECTRUM
来源期刊:Organic Process Research & DevelopmentDOI:10.25039/X46.2019.OP13
BBDFA: A Practical Reagent for Trifluoromethylation of Allylic and Benzylic Alcohols on Preparative Scale
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/ACS.OPRD.9B00201
Mutagenic Impurities in 1-Hydroxybenzotriazole (HOBt)
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/acs.oprd.9b00376
T3P-Mediated N–N Cyclization for the Synthesis of 1,2,4-Triazolo[1,5-a]pyridines
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/acs.oprd.9b00396
Efficient Azacycle Formations Developed in Japanese Pharmaceutical Industries: Elegancy, Logistics, and Training (ELT) “Sandwich” for Process Chemists
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/acs.oprd.8b00412
Performance Characterization of Static Mixers in Precipitating Environments
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/ACS.OPRD.8B00267
De trabajadores a proveedores. La responsabilidad social empresarial y la tercerización laboral en los ingenios azucareros
来源期刊:Organic Process Research & DevelopmentDOI:10.12804/OP9789587843217
Development of a Synthetic Process for K-8986, an H1-Receptor Antagonist
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/ACS.OPRD.8B00380
Efficient and Scalable Synthesis of Glucokinase Activator with a Chiral Thiophenyl-Pyrrolidine Scaffold
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/acs.oprd.8b00354
Effects of Scale, Equipment, and Operation on Agglomeration during a Reactive Crystallization
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/ACS.OPRD.8B00227