Mechanisms of Ageing and Development is a multidisciplinary journal aimed at revealing the molecular, biochemical and biological mechanisms that underlie the processes of aging and development in various species as well as of age-associated diseases. Emphasis is placed on investigations that delineate the contribution of macromolecular damage and cytotoxicity, genetic programs, epigenetics and genetic instability, mitochondrial function, alterations of metabolism and innovative anti-aging approaches. For all of the mentioned studies it is necessary to address the underlying mechanisms.Mechanisms of Ageing and Development publishes original research, review and mini-review articles. The journal also publishes Special Issues that focus on emerging research areas. Special issues may include all types of articles following peered review. Proposals should be sent directly to the Editor-in-Chief.
《衰老与发育机制》是一本多学科期刊，旨在揭示各种物种衰老和发育过程以及与年龄相关疾病的分子、生物化学和生物学机制。重点放在描述大分子损伤和细胞毒性、遗传程序、表观遗传学和遗传不稳定性、线粒体功能、代谢改变和创新抗衰老方法的研究。《老龄化与发展机制》发表原创研究、综述和小型综述文章。该杂志还出版专刊，重点关注新兴的研究领域。特殊问题可能包括同行评审后的所有类型的文章。建议应直接送交主编。
The impact of oxidative DNA damage and stress on telomere homeostasis
来源期刊：Mechanisms of Ageing and DevelopmentDOI：10.1016/j.mad.2018.03.013
Role of hypothalamus in aging and its underlying cellular mechanisms
来源期刊：Mechanisms of Ageing and DevelopmentDOI：10.1016/j.mad.2018.04.008
Age-related deficit accumulation and the diseases of ageing
来源期刊：Mechanisms of Ageing and DevelopmentDOI：10.1016/j.mad.2019.04.005
Tauopathy: A common mechanism for neurodegeneration and brain aging
来源期刊：Mechanisms of Ageing and DevelopmentDOI：10.1016/j.mad.2019.01.007
Frailty biomarkers in humans and rodents: Current approaches and future advances
来源期刊：Mechanisms of Ageing and DevelopmentDOI：10.1016/j.mad.2019.03.007
Rodent models of frailty and their application in preclinical research
来源期刊：Mechanisms of Ageing and DevelopmentDOI：10.1016/j.mad.2019.01.008
Do sex differences in chronic disease underpin the sex-frailty paradox?
来源期刊：Mechanisms of Ageing and DevelopmentDOI：10.1016/j.mad.2019.02.004
The impact of physical activity and sedentary behaviors on frailty levels
来源期刊：Mechanisms of Ageing and DevelopmentDOI：10.1016/j.mad.2019.03.004
Resistin: A reappraisal
来源期刊：Mechanisms of Ageing and DevelopmentDOI：10.1016/j.mad.2019.01.004
Transcriptome profiling of human papillary and reticular fibroblasts from adult interfollicular dermis pinpoints the ‘tissue skeleton’ gene network as a component of skin chrono-ageing
来源期刊：Mechanisms of ageing and developmentDOI：10.1016/j.mad.2019.01.003
Crucial players in Alzheimer’s disease and diabetes mellitus: Friends or foes?
来源期刊：Mechanisms of Ageing and DevelopmentDOI：10.1016/j.mad.2019.03.008
Frailty index as a biomarker of lifespan and healthspan: Focus on pharmacological interventions
来源期刊：Mechanisms of Ageing and DevelopmentDOI：10.1016/j.mad.2019.03.005
Geroprotectors: A role in the treatment of frailty
来源期刊：Mechanisms of Ageing and DevelopmentDOI：10.1016/j.mad.2019.03.002
NF-κB signaling in skin aging
来源期刊：Mechanisms of Ageing and DevelopmentDOI：10.1016/j.mad.2019.111160
Role of MicroRNA-141 in the Aging Musculoskeletal System: A Current Overview
来源期刊：Mechanisms of Ageing and DevelopmentDOI：10.1016/j.mad.2018.12.001
Apolipoprotein E gene in physiological and pathological aging
来源期刊：Mechanisms of Ageing and DevelopmentDOI：10.1016/j.mad.2019.01.005
Immune signatures associated with mortality differ in elderly populations from different birth cohorts and countries even within northern Europe
来源期刊：Mechanisms of Ageing and DevelopmentDOI：10.1016/j.mad.2018.04.005
Classical Monocytes from Older Adults Maintain Capacity for Metabolic Compensation during Glucose Deprivation and Lipopolysaccharide Stimulation
来源期刊：Mechanisms of ageing and developmentDOI：10.1016/j.mad.2019.111146
Extracellular vesicles as an emerging tool for the early detection of Alzheimer’s disease
来源期刊：Mechanisms of Ageing and DevelopmentDOI：10.1016/j.mad.2019.111175
Chromosomal instability and pro-inflammatory response in aging
来源期刊：Mechanisms of Ageing and DevelopmentDOI：10.1016/j.mad.2019.111118
When will my mouse die? Life span prediction based on immune function, redox and behavioural parameters in female mice at the adult age
来源期刊：Mechanisms of Ageing and DevelopmentDOI：10.1016/j.mad.2019.111125
Age and frailty as risk factors for the development of osteoarthritis
来源期刊：Mechanisms of Ageing and DevelopmentDOI：10.1016/j.mad.2019.03.003
Major traits of the senescent phenotype of nucleus pulposus intervertebral disc cells persist under the specific microenvironmental conditions of the tissue
来源期刊：Mechanisms of Ageing and DevelopmentDOI：10.1016/j.mad.2018.05.007
Oxaloacetate decarboxylase FAHD1 – a new regulator of mitochondrial function and senescence
来源期刊：Mechanisms of Ageing and DevelopmentDOI：10.1016/j.mad.2018.07.007
Prognostic networks for unraveling the biological mechanisms of Sarcopenia
来源期刊：Mechanisms of Ageing and DevelopmentDOI：10.1016/j.mad.2019.111129
RETRACTED: Analysis of gut microbiota in long-lived older adults and their relatives: a gradual change with ageing
来源期刊：Mechanisms of Ageing and DevelopmentDOI：10.1016/j.mad.2018.11.001
Epigenetic and redox biomarkers: Novel insights from the MARK-AGE study
来源期刊：Mechanisms of Ageing and DevelopmentDOI：10.1016/j.mad.2018.06.006
The role of the cell-matrix interface in aging and its interaction with the renin-angiotensin system in the aged vasculature.
来源期刊：Mechanisms of ageing and developmentDOI：10.1016/j.mad.2018.04.002
Modulation of frailty syndrome by diet: A review of evidence from mouse studies
来源期刊：Mechanisms of Ageing and DevelopmentDOI：10.1016/j.mad.2019.04.003
The ING1a model of rapid cell senescence
来源期刊：Mechanisms of Ageing and DevelopmentDOI：10.1016/j.mad.2018.06.004
The synergistic action of phosphate and interleukin-6 enhances senescence-associated calcification in vascular smooth muscle cells depending on p53
来源期刊：Mechanisms of Ageing and DevelopmentDOI：10.1016/j.mad.2019.111124
Lamin B receptor (LBR) is involved in the induction of cellular senescence in human cells
来源期刊：Mechanisms of Ageing and DevelopmentDOI：10.1016/j.mad.2019.01.001
Replicative senescence is distinguishable from DNA damage-induced senescence by increased methylation of promoter of rDNA and reduced expression of rRNA
来源期刊：Mechanisms of ageing and developmentDOI：10.1016/j.mad.2019.111149
Brain region-specific effects of long-term caloric restriction on redox balance of the aging rat
来源期刊：Mechanisms of Ageing and DevelopmentDOI：10.1016/j.mad.2019.01.002
Changes of the coronary arteries and cardiac microvasculature with aging: Implications for translational research and clinical practice
来源期刊：Mechanisms of Ageing and DevelopmentDOI：10.1016/j.mad.2019.111161
Linker histones and chromatin remodelling complexes maintain genome stability and control cellular ageing
来源期刊：Mechanisms of Ageing and DevelopmentDOI：10.1016/j.mad.2018.07.002
High intensity interval training improves physical performance in aged female mice: A comparison of mouse frailty assessment tools
来源期刊：Mechanisms of Ageing and DevelopmentDOI：10.1016/j.mad.2019.04.001
Oxidative stress-induced senescence markedly increases disc cell bioenergetics
来源期刊：Mechanisms of Ageing and DevelopmentDOI：10.1016/j.mad.2019.04.006
Astragaloside IV and ferulic acid synergistically promote neurite outgrowth through Nrf2 activation
来源期刊：Mechanisms of Ageing and DevelopmentDOI：10.1016/j.mad.2019.04.002
Klotho gene polymorphisms are associated with healthy aging and longevity: Evidence from a meta-analysis
来源期刊：Mechanisms of Ageing and DevelopmentDOI：10.1016/j.mad.2018.12.003
Multidimensional informatic deconvolution defines gender-specific roles of hypothalamic GIT2 in aging trajectories
来源期刊：Mechanisms of Ageing and DevelopmentDOI：10.1016/j.mad.2019.111150
Prioritized brain selenium retention and selenoprotein expression: Nutritional insights into Parkinson’s disease
来源期刊：Mechanisms of Ageing and DevelopmentDOI：10.1016/j.mad.2019.04.004
Neuroglial patterns are shared by cerebella from prion and prion-like disorder affected patients
来源期刊：Mechanisms of Ageing and DevelopmentDOI：10.1016/j.mad.2019.111176
Interferons: A molecular switch between damage and repair in ageing and Alzheimer’s disease
来源期刊：Mechanisms of Ageing and DevelopmentDOI：10.1016/j.mad.2019.111148
Feed-forward loop between body composition, strength and performance in older adults
来源期刊：Mechanisms of Ageing and DevelopmentDOI：10.1016/j.mad.2019.111130
Knockdown of the neuronal gene Lim3 at the early stages of development affects mitochondrial function and lifespan in Drosophila
来源期刊：Mechanisms of Ageing and DevelopmentDOI：10.1016/j.mad.2019.111121
Telomere length and physical performance among older people—The Helsinki Birth Cohort Study
来源期刊：Mechanisms of Ageing and DevelopmentDOI：10.1016/j.mad.2019.111145
Mitochondrial DNA alterations in aged macrophage migration inhibitory factor-knockout mice
来源期刊：Mechanisms of Ageing and DevelopmentDOI：10.1016/j.mad.2019.111126
Where ageing goes nowadays: Mechanisms, pathways, biomarkers and anti-ageing strategies
来源期刊：Mechanisms of Ageing and DevelopmentDOI：10.1016/j.mad.2018.12.002
