Combinatorial Chemistry & High Throughput Screening (CCHTS) publishes full length original research articles and reviews/mini-reviews dealing with various topics related to chemical biology (High Throughput Screening, Combinatorial Chemistry, Chemoinformatics, Laboratory Automation and Compound management) in advancing drug discovery research. Original research articles and reviews in the following areas are of special interest to the readers of this journal:Target identification and validationAssay design, development, miniaturization and comparisonHigh throughput/high content/in silico screening and associated technologiesLabel-free detection technologies and applicationsStem cell technologiesBiomarkersADMET/PK/PD methodologies and screeningProbe discovery and development, hit to lead optimizationCombinatorial chemistry (e.g. small molecules, peptide, nucleic acid or phage display libraries)Chemical library design and chemical diversityChemo/bio-informatics, data miningCompound managementPharmacognosyNatural Products Research (Chemistry, Biology and Pharmacology of Natural Products)Natural Product Analytical StudiesBipharmaceutical studies of Natural productsDrug repurposingData management and statistical analysisLaboratory automation, robotics, microfluidics, signal detection technologiesCurrent & Future Institutional Research ProfileTechnology transfer, legal and licensing issuesPatents.
组合化学与高通量筛选（CCHTS）出版完整的原创研究文章和评论/小型评论，涉及化学生物学（高通量筛选、组合化学、化学信息学、实验室自动化和化合物管理）在推进药物发现研究中的各种主题。以下领域的原创研究文章和综述对本杂志的读者特别有意义：靶点鉴定和验证试验设计、开发、微型化和比较高通量/高含量/计算机筛选和相关技术无标记检测技术和应用干细胞技术生物标志物ADMET/PK/PD方法学和筛选探针发现和开发，命中先导优化组合化学（如小分子、肽、核酸或噬菌体展示文库）化学文库设计和化学多样性化学/生物信息学、数据挖掘化合物管理生药学天然产物研究（天然产物的化学、生物学和药理学）天然产物分析研究天然产物的生物制药研究药物再利用数据管理和统计分析实验室自动化、机器人、微流体、信号检测技术当前和未来机构研究概况技术转让、法律的和许可问题专利。
Drug target group prediction with multiple drug networks.
来源期刊：Combinatorial chemistry & high throughput screeningDOI：10.2174/1386207322666190702103927
Progress in Molecularly Imprinted Polymers for Biomedical Applications.
来源期刊：Combinatorial chemistry & high throughput screeningDOI：10.2174/1386207322666190325115526
The key microRNAs regulated the development of non-small cell lung cancer by targeting TGF-β-induced epithelial-mesenchymal transition.
来源期刊：Combinatorial chemistry & high throughput screeningDOI：10.2174/1386207322666190410151945
Green Fabrication of Cobalt NPs using Aqueous Extract of Antioxidant Rich Zingiber and Their Catalytic Applications for the Synthesis of Pyrano[2,3-c]pyrazoles.
来源期刊：Combinatorial chemistry & high throughput screeningDOI：10.2174/1386207322666190307160354
Efficacy and safety of robot-assisted thoracic surgery (RATS) compare with video-assisted thoracoscopic surgery (VATS) for lung lobectomy in patients with non-small cell lung cancer.
来源期刊：Combinatorial chemistry & high throughput screeningDOI：10.2174/1386207322666190411113040
Video-assisted Thoracoscopic Surgery versus Thoracotomy for Non-Small Cell Lung Cancer: A Meta-Analysis.
来源期刊：Combinatorial chemistry & high throughput screeningDOI：10.2174/1386207322666190415103030
Effect of Chinese herbal monomer hairy Calycosin on nonalcoholic fatty liver rats and its mechanism.
来源期刊：Combinatorial chemistry & high throughput screeningDOI：10.2174/1386207322666190411112814
MADD expression in lung adenocarcinoma and its impact on proliferation and apoptosis of lung adenocarcinoma cells.
来源期刊：Combinatorial chemistry & high throughput screeningDOI：10.2174/1386207322666190404151437
Biochemometrics and Required Tools in Botanical Natural Products Research: A Review.
来源期刊：Combinatorial chemistry & high throughput screeningDOI：10.2174/1386207322666190704094003
Prediction of Citrullination Sites on the Basis of mRMR Method and SNN.
来源期刊：Combinatorial chemistry & high throughput screeningDOI：10.2174/1386207322666191129113508
Relating Substructures and Side Effects of Drugs with Chemical-Chemical Interactions.
来源期刊：Combinatorial chemistry & high throughput screeningDOI：10.2174/1386207322666190702102752
A random forest model to predict the activity of a large set of soluble epoxide hydrolase inhibitors solely based on a set of simple fragmental descriptors.
来源期刊：Combinatorial chemistry & high throughput screeningDOI：10.2174/1386207322666191016110232
Contribution of Resveratrol in Development of Novel Urease Inhibitors: Synthesis, Biological Evaluation and Molecular Docking Studies.
来源期刊：Combinatorial chemistry & high throughput screeningDOI：10.2174/1386207322666190410150216
The Relationship Between Prolidase Activity and Atrial Electromechanical Changes in Patients with Paroxysmal Atrial Fibrillation.
来源期刊：Combinatorial chemistry & high throughput screeningDOI：10.2174/1386207322666190306143317
How Do Contrast Agents Affect Cardiac Markers and Coagulation Tests? Experimental Study.
来源期刊：Combinatorial chemistry & high throughput screeningDOI：10.2174/1386207322666190603170438
Statistical Modelling Outcome of In Vitro Fertilization and Intracytoplasmic Sperm Injection.
来源期刊：Combinatorial chemistry & high throughput screeningDOI：10.2174/1386207322666190404145448
False Immunosuppressant Measurement by LC-MS/MS Method Due to Radiopaque Agents.
来源期刊：Combinatorial chemistry & high throughput screeningDOI：10.2174/1386207322666190418125307
Misdiagnosis of Intrahepatic Biliary Cystadenoma Located in Caudate Lobe: A Case Report.
来源期刊：Combinatorial chemistry & high throughput screeningDOI：10.2174/1386207322666190402162614
Reynoutria japonica from Traditional Chinese Medicine: A source of Competitive Adenosine Deaminase Inhibitors for Anticancer.
来源期刊：Combinatorial chemistry & high throughput screeningDOI：10.2174/1386207322666190415100618
Closed loop duodenal obstruction secondary to pancreatic carcinoma: a case report.
来源期刊：Combinatorial chemistry & high throughput screeningDOI：10.2174/1386207322666190411112412
Facile Synthesis and Cytotoxicity of Phenazine-Chromene Hybrid Molecules Derived from Phenazine Natural Product.
来源期刊：Combinatorial chemistry & high throughput screeningDOI：10.2174/1386207322666190307125015
Drug repurposing screen identifies novel classes of drugs with anticancer activity in mantle cell lymphoma.
来源期刊：Combinatorial chemistry & high throughput screeningDOI：10.2174/1386207322666190916120128
Chlorosulfonic Acid Supported Piperidine-4-carboxylic Acid (PPCA) Functionalized Fe3O4 Nanoparticles (Fe3O4-PPCA): The Efficient, Green and Reusable Nanocatalyst for the Synthesis of Pyrazolyl Coumarin Derivatives under Solvent Free Conditions.
来源期刊：Combinatorial chemistry & high throughput screeningDOI：10.2174/1386207322666190325120715
Synthesis of 2-substituted 4-arylidene-5(4H)-oxazolones as potential cytotoxic agents in the presence of lemon juice as a biocatalyst.
来源期刊：Combinatorial chemistry & high throughput screeningDOI：10.2174/1386207322666191024105150
Quantitative structure-activity relationship study of camptothecin derivatives as anticancer drugs using molecular descriptors.
来源期刊：Combinatorial chemistry & high throughput screeningDOI：10.2174/1386207322666190708112251
Salivary antioxidants and oxidative stress markers in male smokers.
来源期刊：Combinatorial chemistry & high throughput screeningDOI：10.2174/1386207322666190806123616
Can IL-33 and Endocan be New Markers for Retinopathy of Prematurity?
来源期刊：Combinatorial chemistry & high throughput screeningDOI：10.2174/1386207322666190325120244
Plasma-free amino acid profiling of nasal polyposis patients.
来源期刊：Combinatorial chemistry & high throughput screeningDOI：10.2174/1386207322666190920110324
Constructing Prediction Model of Lung Cancer Recurrence Risk Using Gene Function Clustering and Machine Learning.
来源期刊：Combinatorial chemistry & high throughput screeningDOI：10.2174/1386207322666190129111749
QSAR Models for Predicting Aquatic Toxicity of Esters Using Genetic Algorithm-Multiple Linear Regression Methods and Molecular Descriptors.
来源期刊：Combinatorial chemistry & high throughput screeningDOI：10.2174/1386207322666190618150856
Comparison of the Full-Length and 152~528 Truncate of Human Cyclic Nucleotide Phosphodiesterase 4B2 for the Characterization of Inhibitors.
来源期刊：Combinatorial chemistry & high throughput screeningDOI：10.2174/1386207322666190306142810
Ultrastructural Analysis of Human Gallstones using Synchrotron Radiation µCT.
来源期刊：Combinatorial chemistry & high throughput screeningDOI：10.2174/1386207322666190222122007
In Silico Molecular Docking, Synthesis of 4-(4-benzoylaminophenoxy) Phenol Derivatives as Androgen Receptor Antagonists.
来源期刊：Combinatorial chemistry & high throughput screeningDOI：10.2174/1386207322666190701124752
Multiple-line Chemotherapy and Tyrosine Kinase Inhibitor Treatment in Patients with Advanced Lung Cancer.
来源期刊：Combinatorial chemistry & high throughput screeningDOI：10.2174/1386207322666181231122030
Current Approaches of Drug Discovery for Chagas Disease: Methodological Advances.
来源期刊：Combinatorial chemistry & high throughput screeningDOI：10.2174/1386207322666191010144111
Identification of N-Substituted Triazolo-azetidines as Novel Antibacterials using pDualrep2 HTS Platform.
来源期刊：Combinatorial chemistry & high throughput screeningDOI：10.2174/1386207322666190412165316
Density functional theory study of adsorption of Melatonin, Vitamin C, Glutathione and Lipoic acid antioxidants onto single-wall boron nitride nanotubes in the external electric field: Design of new antioxidants delivery vehicles.
来源期刊：Combinatorial chemistry & high throughput screeningDOI：10.2174/1386207322666190930113200
Quantitative Structure-activity Relationship Analysis for Predicting Lipophilicity of Aniline Derivatives (Including some Pharmaceutical Compounds).
来源期刊：Combinatorial chemistry & high throughput screeningDOI：10.2174/1386207322666190419111559
Green chemistry preparation of thiochromeno[4,3-b]pyran and benzo[h]thiazolo[2,3-b]quinazoline derivatives using HSBM technique over ZnAl2O4 nano-powders.
来源期刊：Combinatorial chemistry & high throughput screeningDOI：10.2174/1386207322666190617164617
Synthesis, Molecular Docking and Biological Evaluation of 2-Mercaptoimidazoles using solid phase synthesis.
来源期刊：Combinatorial chemistry & high throughput screeningDOI：10.2174/1386207322666190425150818
From the Explored to the Unexplored: Computer-Tailored Drug Design Attempts in the Discovery of Selective Caspases Inhibitors.
来源期刊：Combinatorial chemistry & high throughput screeningDOI：10.2174/1386207322666190927143026
Exploration of the Hepatoprotective Effect and Mechanism of Swertia mussotii Franch in an Acute Liver Injury Rat Model.
来源期刊：Combinatorial chemistry & high throughput screeningDOI：10.2174/1386207322666191106105725
New Amine and Aromatic Substituted Analogues of Phencyclidine: Synthesis and Determination of Acute and Chronic Pain Activities.
来源期刊：Combinatorial chemistry & high throughput screeningDOI：10.2174/1386207322666191016152157
Screening GLP-1 Receptor Ligands from Natural Products in Herbs through High-Content Technique.
来源期刊：Combinatorial chemistry & high throughput screeningDOI：10.2174/1386207322666190919143735
Riboswitches in Archaea.
来源期刊：Combinatorial chemistry & high throughput screeningDOI：10.2174/1386207322666190425143301
Evaluatıon of Mıcro-RNA Levels, Apoptosıs and Oxıdatıve Stress Markers in Patıents Recıevıng Chemotherapy.
来源期刊：Combinatorial chemistry & high throughput screeningDOI：10.2174/1386207323666191224111348
The effect of temperature on the interaction of phenanthroline-based ligands with G-quadruplex: In silico viewpoint.
来源期刊：Combinatorial chemistry & high throughput screeningDOI：10.2174/1386207322666191022142629
Invasive-noninvasive sequential ventilation for the treatment of acute exacerbation of chronic obstructive pulmonary disease.
来源期刊：Combinatorial chemistry & high throughput screeningDOI：10.2174/1386207322666190415101408
Green synthesis of 4H-pyran derivatives using Fe3O4-MNPs as efficient nanocatalyst: Study of antioxidant activity.
来源期刊：Combinatorial chemistry & high throughput screeningDOI：10.2174/1386207322666191022130235
The effectiveness and safety of open versus laparoscopic surgery for rectal cancer after preoperative chemo-radiotherapy: a meta-analysis.
来源期刊：Combinatorial chemistry & high throughput screeningDOI：10.2174/1386207322666190415102505
