Chemico-Biological Interactions publishes research reports and review articles that examine the molecular, cellular, and/or biochemical basis of toxicologically relevant outcomes. Special emphasis is placed on toxicological mechanisms associated with interactions between chemicals and biological systems. Outcomes may include all traditional endpoints caused by synthetic or naturally occurring chemicals, both in vivo and in vitro. Endpoints of interest include, but are not limited to carcinogenesis, mutagenesis, respiratory toxicology, neurotoxicology, reproductive and developmental toxicology, and immunotoxicology.
化学-生物学相互作用出版研究报告和综述文章，检查毒理学相关结果的分子、细胞和/或生化基础。特别强调与化学品和生物系统之间相互作用相关的毒理学机制。结果可能包括体内和体外合成或天然化学品引起的所有传统终点。感兴趣的终点包括但不限于致癌作用、诱变、呼吸毒理学、神经毒理学、生殖和发育毒理学以及免疫毒理学。
Computer-designed active human butyrylcholinesterase double mutant with a new catalytic triad.
来源期刊：Chemico-biological interactionsDOI：10.1016/j.cbi.2019.04.019
Chitosan oligosaccharides prevent doxorubicin-induced oxidative stress and cardiac apoptosis through activating p38 and JNK MAPK mediated Nrf2/ARE pathway.
来源期刊：Chemico-biological interactionsDOI：10.1016/j.cbi.2019.03.027
The linear no-threshold model is less realistic than threshold or hormesis-based models: An evolutionary perspective.
来源期刊：Chemico-biological interactionsDOI：10.1016/j.cbi.2018.10.007
Matrine induces apoptosis and autophagy of glioma cell line U251 by regulation of circRNA-104075/BCL-9.
来源期刊：Chemico-biological interactionsDOI：10.1016/j.cbi.2019.05.030
Downregulation of microRNA-532-5p promotes the proliferation and invasion of bladder cancer cells through promotion of HMGB3/Wnt/β-catenin signaling.
来源期刊：Chemico-biological interactionsDOI：10.1016/j.cbi.2019.01.015
β-Caryophyllene, a natural bicyclic sesquiterpene attenuates doxorubicin-induced chronic cardiotoxicity via activation of myocardial cannabinoid type-2 (CB2) receptors in rats.
来源期刊：Chemico-biological interactionsDOI：10.1016/j.cbi.2019.02.028
A new pyrrole based small molecule from Tinospora cordifolia induces apoptosis in MDA-MB-231 breast cancer cells via ROS mediated mitochondrial damage and restoration of p53 activity.
来源期刊：Chemico-biological interactionsDOI：10.1016/j.cbi.2018.12.005
Hyperoside protects rat ovarian granulosa cells against hydrogen peroxide-induced injury by sonic hedgehog signaling pathway.
来源期刊：Chemico-biological interactionsDOI：10.1016/j.cbi.2019.108759
Buparlisib is a novel inhibitor of daunorubicin reduction mediated by aldo-keto reductase 1C3.
来源期刊：Chemico-biological interactionsDOI：10.1016/j.cbi.2019.01.026
Isorhamnetin glycoside isolated from Opuntia ficus-indica (L.) MilI induces apoptosis in human colon cancer cells through mitochondrial damage.
来源期刊：Chemico-biological interactionsDOI：10.1016/j.cbi.2019.108734
Zolmitriptan attenuates hepatocellular carcinoma via activation of caspase mediated apoptosis.
来源期刊：Chemico-biological interactionsDOI：10.1016/j.cbi.2019.05.033
Downregulation of Bach1 protects osteoblasts against hydrogen peroxide-induced oxidative damage in vitro by enhancing the activation of Nrf2/ARE signaling.
来源期刊：Chemico-biological interactionsDOI：10.1016/j.cbi.2019.06.019
GSPE alleviates renal fibrosis by inhibiting the activation of C3/ HMGB1/ TGF-β1 pathway.
来源期刊：Chemico-biological interactionsDOI：10.1016/j.cbi.2019.108926
Effects of new tetrahydroquinoline-isoxazole hybrids on bioenergetics of hepatocarcinoma Hep-G2 cells and rat liver mitochondria.
来源期刊：Chemico-biological interactionsDOI：10.1016/j.cbi.2019.02.002
The impact of dose rate on the linear no threshold hypothesis.
来源期刊：Chemico-biological interactionsDOI：10.1016/j.cbi.2018.12.007
Dimethylsphingosine and miltefosine induce apoptosis in lung adenocarcinoma A549\u202fcells in a synergistic manner.
来源期刊：Chemico-biological interactionsDOI：10.1016/j.cbi.2019.108731
Pharmacokinetics of K117 and K127, two novel antidote candidates to treat Tabun poisoning.
来源期刊：Chemico-biological interactionsDOI：10.1016/j.cbi.2019.108737
PDGFBB-modified stem cells from apical papilla and thermosensitive hydrogel scaffolds induced bone regeneration.
来源期刊：Chemico-biological interactionsDOI：10.1016/j.cbi.2019.108931
Molecular dynamics simulations of the interaction of Mouse and Torpedo acetylcholinesterase with covalent inhibitors explain their differential reactivity: Implications for drug design.
来源期刊：Chemico-biological interactionsDOI：10.1016/j.cbi.2019.06.028
Marine natural compound cyclo(L-leucyl-L-prolyl) peptide inhibits migration of triple negative breast cancer cells by disrupting interaction of CD151 and EGFR signaling.
来源期刊：Chemico-biological interactionsDOI：10.1016/j.cbi.2019.108872
Synthesis, characterization and toxicity assessment of a new polymeric nanoparticle, l-glutamic acid-g-p(HEMA).
来源期刊：Chemico-biological interactionsDOI：10.1016/j.cbi.2019.108870
Penta-O-galloyl-β-d-glucose, a hydrolysable tannin from Radix Paeoniae Alba, inhibits adipogenesis and TNF-α-mediated inflammation in 3T3-L1 cells.
来源期刊：Chemico-biological interactionsDOI：10.1016/j.cbi.2019.01.037
Overexpression of glutathione peroxidase-1 attenuates cocaine-induced reproductive dysfunction in male mice by inhibiting nuclear factor κB.
来源期刊：Chemico-biological interactionsDOI：10.1016/j.cbi.2019.05.001
Human and murine steroid 5β-reductases (AKR1D1 and AKR1D4): insights into the role of the catalytic glutamic acid.
来源期刊：Chemico-biological interactionsDOI：10.1016/j.cbi.2019.03.025
Pharmacokinetic study of precisely representative antidepressant, prokinetic, anti-inflammatory and anti-oxidative compounds from Fructus aurantii and Magnolia Bark.
来源期刊：Chemico-biological interactionsDOI：10.1016/j.cbi.2019.108851
Neutral endopeptidase (NEP) inhibitors - thiorphan, sialorphin, and its derivatives exert anti-proliferative activity towards colorectal cancer cells in vitro.
来源期刊：Chemico-biological interactionsDOI：10.1016/j.cbi.2019.04.033
The suppressed autophagy induced by carbon disulfide could be rescued by N-carbamoyl glutamate during the window of embryo implantation in mice.
来源期刊：Chemico-biological interactionsDOI：10.1016/j.cbi.2019.108751
Azure B affects amyloid precursor protein metabolism in PS70\u202fcells.
来源期刊：Chemico-biological interactionsDOI：10.1016/j.cbi.2018.11.023
