Cell Biology and Toxicology (CBT) is an international journal focused on clinical and translational research with an emphasis on molecular and cell biology, genetic and epigenetic heterogeneity, drug discovery and development, and molecular pharmacology and toxicology. CBT has a disease-specific scope prioritizing publications on gene and protein-based regulation, intracellular signaling pathway dysfunction, cell type-specific function, and systems in biomedicine in drug discovery and development. CBT publishes original articles with outstanding, innovative and significant findings, important reviews on recent research advances and issues of high current interest, opinion articles of leading edge science, and rapid communication or reports, on molecular mechanisms and therapies in diseases.
《细胞生物学与毒理学》（CBT）是一本国际期刊，主要关注临床和转化研究，重点关注分子和细胞生物学、遗传和表观遗传异质性、药物发现和开发以及分子药理学和毒理学。CBT具有疾病特异性的范围，优先出版关于基因和蛋白质调控、细胞内信号通路功能障碍、细胞类型特异性功能以及药物发现和开发中的生物医学系统的出版物。CBT发表具有杰出、创新和重大发现的原创文章，对最近的研究进展和当前高度关注的问题进行重要评论，发表前沿科学的观点文章，并就疾病的分子机制和治疗进行快速交流或报告。
Current perspectives of cancer-associated fibroblast in therapeutic resistance: potential mechanism and future strategy
来源期刊：Cell Biology and ToxicologyDOI：10.1007/s10565-019-09461-z
Proteomic and genomic profiling of pancreatic cancer
来源期刊：Cell Biology and ToxicologyDOI：10.1007/s10565-019-09465-9
A new pyridazinone exhibits potent cytotoxicity on human cancer cells via apoptosis and poly-ubiquitinated protein accumulation
来源期刊：Cell Biology and ToxicologyDOI：10.1007/s10565-019-09466-8
Cell death mechanisms in eukaryotes
来源期刊：Cell Biology and ToxicologyDOI：10.1007/s10565-019-09496-2
Current understanding of the therapeutic benefits of mesenchymal stem cells in acute respiratory distress syndrome
来源期刊：Cell Biology and ToxicologyDOI：10.1007/s10565-019-09493-5
Clinical protein science in translational medicine targeting malignant melanoma
来源期刊：Cell Biology and ToxicologyDOI：10.1007/s10565-019-09468-6
Minimizing off-target effects in CRISPR-Cas9 genome editing
来源期刊：Cell Biology and ToxicologyDOI：10.1007/s10565-019-09486-4
Protein carbonylation in human bronchial epithelial cells exposed to cigarette smoke extract
来源期刊：Cell Biology and ToxicologyDOI：10.1007/s10565-019-09460-0
Exosomes produced from 3D cultures of umbilical cord mesenchymal stem cells in a hollow-fiber bioreactor show improved osteochondral regeneration activity
来源期刊：Cell Biology and ToxicologyDOI：10.1007/s10565-019-09504-5
Lifetime extension of humpback whale skin fibroblasts and their response to lipopolysaccharide (LPS) and a mixture of polychlorinated biphenyls (Aroclor)
来源期刊：Cell Biology and ToxicologyDOI：10.1007/s10565-018-09457-1
Resveratrol inhibits the proliferation of estrogen receptor-positive breast cancer cells by suppressing EZH2 through the modulation of ERK1/2 signaling
来源期刊：Cell Biology and ToxicologyDOI：10.1007/s10565-019-09471-x
Off-target genome editing: A new discipline of gene science and a new class of medicine
来源期刊：Cell Biology and ToxicologyDOI：10.1007/s10565-019-09475-7
Battling CRISPR-Cas9 off-target genome editing
来源期刊：Cell Biology and ToxicologyDOI：10.1007/s10565-019-09485-5
Interaction of EZH2 and P65 is involved in the arsenic trioxide-induced anti-angiogenesis in human triple-negative breast cancer cells
来源期刊：Cell Biology and ToxicologyDOI：10.1007/s10565-018-09458-0
The sodium pump α1 subunit regulates bufalin sensitivity of human glioblastoma cells through the p53 signaling pathway
来源期刊：Cell Biology and ToxicologyDOI：10.1007/s10565-019-09462-y
Temozolomide induces activation of Wnt/β-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy
来源期刊：Cell Biology and ToxicologyDOI：10.1007/s10565-019-09502-7
CRISPR-Cas12 and Cas13: the lesser known siblings of CRISPR-Cas9
来源期刊：Cell Biology and ToxicologyDOI：10.1007/s10565-019-09489-1
Off-target challenge for base editor-mediated genome editing
来源期刊：Cell Biology and ToxicologyDOI：10.1007/s10565-019-09474-8
Definition of clinical gene tests
来源期刊：Cell Biology and ToxicologyDOI：10.1007/s10565-019-09464-w
Roles of TGFβ1 in the expression of phosphoinositide 3-kinase isoform genes and sensitivity and response of lung telocytes to PI3K inhibitors
来源期刊：Cell Biology and ToxicologyDOI：10.1007/s10565-019-09487-3
CRISPR off-targets: a question of context
来源期刊：Cell Biology and ToxicologyDOI：10.1007/s10565-019-09497-1
A new light of proteomics in cell biology and toxicology
来源期刊：Cell Biology and ToxicologyDOI：10.1007/s10565-019-09492-6
Protein and lipid homeostasis altered in rat macrophages after exposure to metallic oxide nanoparticles
来源期刊：Cell Biology and ToxicologyDOI：10.1007/s10565-019-09484-6
Relevance of Erk1/2-PI3K/Akt signaling pathway in CEES-induced oxidative stress regulates inflammation and apoptosis in keratinocytes
来源期刊：Cell Biology and ToxicologyDOI：10.1007/s10565-019-09467-7
HDAC2-mediated upregulation of IL-6 triggers the migration of osteosarcoma cells
来源期刊：Cell Biology and ToxicologyDOI：10.1007/s10565-019-09459-7
Novel biphenyl diester derivative AB-38b inhibits NLRP3 inflammasome through Nrf2 activation in diabetic nephropathy
来源期刊：Cell Biology and ToxicologyDOI：10.1007/s10565-019-09501-8
Genome-wide off-targets of drugs: risks and opportunities
来源期刊：Cell Biology and ToxicologyDOI：10.1007/s10565-019-09491-7
Targeting neddylation inhibits intravascular survival and extravasation of cancer cells to prevent lung-cancer metastasis
来源期刊：Cell Biology and ToxicologyDOI：10.1007/s10565-019-09472-w
Refining CRISPR-based genome and epigenome editing off-targets
来源期刊：Cell Biology and ToxicologyDOI：10.1007/s10565-019-09482-8
In vitro toxicological assessment of free 3-MCPD and select 3-MCPD esters on human proximal tubule HK-2 cells
来源期刊：Cell Biology and ToxicologyDOI：10.1007/s10565-019-09498-0
Luteolin modulates gene expression related to steroidogenesis, apoptosis, and stress response in rat LC540 tumor Leydig cells
来源期刊：Cell Biology and ToxicologyDOI：10.1007/s10565-019-09481-9
Mitochondrial dysfunction and chronic lung disease
来源期刊：Cell Biology and ToxicologyDOI：10.1007/s10565-019-09473-9
Activation of SIRT1 by l-serine increases fatty acid oxidation and reverses insulin resistance in C2C12 myotubes (l-serine activates SIRT1 in C2C12 myotubes)
来源期刊：Cell Biology and ToxicologyDOI：10.1007/s10565-019-09463-x
An essential role for GLUT5-mediated fructose utilization in exacerbating the malignancy of clear cell renal cell carcinoma
来源期刊：Cell Biology and ToxicologyDOI：10.1007/s10565-019-09478-4
Keeping our eyes on CRISPR: the “Atlas” of gene editing
来源期刊：Cell Biology and ToxicologyDOI：10.1007/s10565-019-09480-w
Remarkable apoptotic pathway of Hemiscorpius lepturus scorpion venom on CT26 cell line
来源期刊：Cell Biology and ToxicologyDOI：10.1007/s10565-018-09455-3
BSA-bounded p-cresyl sulfate potentiates the malignancy of bladder carcinoma by triggering cell migration and EMT through the ROS/Src/FAK signaling pathway
来源期刊：Cell Biology and ToxicologyDOI：10.1007/s10565-019-09509-0
Peroxiredoxin 4 ameliorates amyloid beta oligomer-mediated apoptosis by inhibiting ER-stress in HT-22 hippocampal neuron cells
来源期刊：Cell Biology and ToxicologyDOI：10.1007/s10565-019-09477-5
Novel functional proteins coded by the human genome discovered in metastases of melanoma patients
来源期刊：Cell Biology and ToxicologyDOI：10.1007/s10565-019-09494-4
Nuphar alkaloids induce very rapid apoptosis through a novel caspase-dependent but BAX/BAK-independent pathway
来源期刊：Cell Biology and ToxicologyDOI：10.1007/s10565-019-09469-5
Bone microenvironment signaling of cancer stem cells as a therapeutic target in metastatic prostate cancer
来源期刊：Cell Biology and ToxicologyDOI：10.1007/s10565-019-09483-7
Correction to: Protein and lipid homeostasis altered in rat macrophages after exposure to metallic oxide nanoparticles
来源期刊：Cell Biology and ToxicologyDOI：10.1007/s10565-019-09507-2
Down-regulation of aryl hydrocarbon receptor intensifies carcinogen-induced retinal lesion via SOCS3-STAT3 signaling
来源期刊：Cell Biology and ToxicologyDOI：10.1007/s10565-019-09499-z
Correction to: Is the clinical lipidomics a potential goldmine?
来源期刊：Cell Biology and ToxicologyDOI：10.1007/s10565-019-09490-8
Applying switchable Cas9 variants to in vivo gene editing for therapeutic applications
来源期刊：Cell Biology and ToxicologyDOI：10.1007/s10565-019-09488-2
Correction to: Activation of SIRT1 by L-serine increases fatty acid oxidation and reverses insulin resistance in C2C12 myotubes
来源期刊：Cell Biology and ToxicologyDOI：10.1007/s10565-019-09476-6
Long-term treatment with arsenite activates HER1 and HER2 through upregulating EGF, TGFα, and HSP90 in a human uroepithelial cell line
来源期刊：Cell Biology and ToxicologyDOI：10.1007/s10565-019-09500-9
Trichloroethylene-induced downregulation of miR-199b-5p contributes to SET-mediated apoptosis in hepatocytes
来源期刊：Cell Biology and ToxicologyDOI：10.1007/s10565-019-09479-3
Understanding off-target effects through hybridization kinetics and thermodynamics
来源期刊：Cell Biology and ToxicologyDOI：10.1007/s10565-019-09505-4
Evidence for the critical role of the PI3K signaling pathway in particulate matter-induced dysregulation of the inflammatory mediators COX-2/PGE2 and the associated epithelial barrier protein Filaggrin in the bronchial epithelium
来源期刊：Cell Biology and ToxicologyDOI：10.1007/s10565-019-09508-1
