Clinical Therapeutics provides peer-reviewed, rapid publication of recent developments in drug and other therapies as well as in diagnostics, pharmacoeconomics, health policy, treatment outcomes, and innovations in drug and biologics research. In addition Clinical Therapeutics features updates on specific topics collated by expert Topic Editors. Clinical Therapeutics is read by a large international audience of scientists and clinicians in a variety of research, academic, and clinical practice settings. Articles are indexed by all major biomedical abstracting databases.
临床治疗学提供同行评审，快速出版的最新发展，在药物和其他疗法，以及在诊断，药物经济学，卫生政策，治疗结果，以及创新的药物和生物制剂研究。此外，《临床治疗学》还提供了由专家主题编辑整理的特定主题的更新。临床治疗学是由大量的科学家和临床医生在各种研究，学术和临床实践设置的国际观众阅读。所有主要生物医学摘要数据库均对文章进行了索引。
Association Between Immune-Related Adverse Events and Clinical Efficacy in Patients with Melanoma Treated With Nivolumab: A Multicenter Retrospective Study.
来源期刊：Clinical therapeuticsDOI：10.1016/j.clinthera.2018.11.004
The Natural History of Rheumatoid Arthritis.
来源期刊：Clinical therapeuticsDOI：10.1016/j.clinthera.2019.04.028
Normal Weight Obesity: An Underrecognized Problem in Individuals of South Asian Descent.
来源期刊：Clinical therapeuticsDOI：10.1016/j.clinthera.2019.05.016
Drug Discontinuation in Studies Including a Switch From an Originator to a Biosimilar Monoclonal Antibody: A Systematic Literature Review.
来源期刊：Clinical therapeuticsDOI：10.1016/j.clinthera.2018.11.002
Recurrent Thrombosis With Direct Oral Anticoagulants in Antiphospholipid Syndrome: A Systematic Literature Review and Meta-analysis.
来源期刊：Clinical therapeuticsDOI：10.1016/j.clinthera.2019.06.015
Colchicine for Stroke Prevention: A Systematic Review and Meta-analysis.
来源期刊：Clinical therapeuticsDOI：10.1016/j.clinthera.2019.02.003
Lipoprotein(a): Current Evidence for a Physiologic Role and the Effects of Nutraceutical Strategies.
来源期刊：Clinical therapeuticsDOI：10.1016/j.clinthera.2019.06.002
Colchicine as a Novel Therapy for Suppressing Chemokine Production in Patients With an Acute Coronary Syndrome: A Pilot Study.
来源期刊：Clinical therapeuticsDOI：10.1016/j.clinthera.2019.07.015
The impact of the opioid epidemic on children and adolescents.
来源期刊：Clinical therapeuticsDOI：10.1016/j.clinthera.2019.06.003
Effects of Sodium-glucose Cotransporter 2 Inhibitor Monotherapy on Weight Changes in Patients With Type 2 Diabetes Mellitus: a Bayesian Network Meta-analysis.
来源期刊：Clinical therapeuticsDOI：10.1016/j.clinthera.2019.01.001
Evaluating Benefit-risk Decision-making in Spinal Muscular Atrophy: A First-ever Study to Assess Risk Tolerance in the SMA Patient Community.
来源期刊：Clinical therapeuticsDOI：10.1016/j.clinthera.2019.03.012
A Single-dose, Comparative Bioavailability Study of a Formulation containing OM3 as Phospholipid and Free Fatty Acid to an Ethyl Ester Formulation in the Fasting and Fed States.
来源期刊：Clinical therapeuticsDOI：10.1016/j.clinthera.2019.01.017
Utility of Therapeutic Drug Monitoring of Imatinib, Nilotinib, and Dasatinib in Chronic Myeloid Leukemia: A Systematic Review and Meta-analysis.
来源期刊：Clinical therapeuticsDOI：10.1016/j.clinthera.2019.10.009
Mucosa Biology and the Development of Rheumatoid Arthritis: Potential for Prevention by Targeting Mucosal Processes.
来源期刊：Clinical therapeuticsDOI：10.1016/j.clinthera.2019.04.012
The Importance of Tablet Formulation on Allergen Release Kinetics and Efficiency: Comparison of Freeze-dried and Compressed Grass Pollen Sublingual Allergy Immunotherapy Tablet Formulations.
来源期刊：Clinical therapeuticsDOI：10.1016/j.clinthera.2019.02.008
Efficacy and Tolerability of Sufentanil, Dexmedetomidine, or Ketamine Added to Propofol-Based Sedation for Gastrointestinal Endoscopy in Elderly Patients: A Prospective, Randomized, Controlled Trial.
来源期刊：Clinical therapeuticsDOI：10.1016/j.clinthera.2019.06.011
Harmonization of Pharmacovigilance Regulation in Brazil: Opportunities to Improve Risk Communication.
来源期刊：Clinical therapeuticsDOI：10.1016/j.clinthera.2019.01.013
Managing Procedural Pain in the Neonate Using an Opioid-sparing Approach.
来源期刊：Clinical therapeuticsDOI：10.1016/j.clinthera.2019.07.014
Host-Pathogen Interactions in Coccidioidomycosis: Prognostic Clues and Opportunities for Novel Therapies.
来源期刊：Clinical therapeuticsDOI：10.1016/j.clinthera.2019.08.011
Medication Adherence, Health Care Utilization, and Costs in Patients With Major Depressive Disorder Initiating Adjunctive Atypical Antipsychotic Treatment.
来源期刊：Clinical therapeuticsDOI：10.1016/j.clinthera.2018.12.005
Fatigue in Mastocytosis: A Case Series.
来源期刊：Clinical therapeuticsDOI：10.1016/j.clinthera.2019.01.016
Using Patient Advisory Boards to Solicit Input Into Clinical Trial Design and Execution.
来源期刊：Clinical therapeuticsDOI：10.1016/j.clinthera.2019.06.006
Daratumumab Split First Versus Single Dosing Schedule Among Patients With Multiple Myeloma Treated in a US Community Oncology Setting: A Retrospective Observational Study.
来源期刊：Clinical therapeuticsDOI：10.1016/j.clinthera.2019.03.013
Predicting Rheumatoid Arthritis in At-Risk Individuals.
来源期刊：Clinical therapeuticsDOI：10.1016/j.clinthera.2019.04.017
Efficacy and tolerability of intravenous immunoglobulin and subcutaneous immunoglobulin in neurologic diseases.
来源期刊：Clinical therapeuticsDOI：10.1016/j.clinthera.2019.07.009
Peripartum Management of Gestational Diabetes Using a Digital Health Care Service: A Pilot, Randomized Controlled Study.
来源期刊：Clinical therapeuticsDOI：10.1016/j.clinthera.2019.09.005
Efficacy and Safety of Udenafil for the Treatment of Pulmonary Arterial Hypertension: a Placebo-controlled, Double-blind, Phase IIb Clinical Trial.
来源期刊：Clinical therapeuticsDOI：10.1016/j.clinthera.2019.05.006
Burden of Carcinoid Heart Disease in Patients With Carcinoid Syndrome Initiating Somatostatin Analogues.
来源期刊：Clinical therapeuticsDOI：10.1016/j.clinthera.2019.06.013
Outcomes of Macrolide Deescalation in Severe Community-Acquired Pneumonia.
来源期刊：Clinical therapeuticsDOI：10.1016/j.clinthera.2019.10.005
Estimating the Cost of Illness of Prostate Cancer in Iran.
来源期刊：Clinical therapeuticsDOI：10.1016/j.clinthera.2018.11.001
Effects of food and calcium carbonate on the pharmacokinetics of lusutrombopag, a novel thrombopoietin receptor agonist.
来源期刊：Clinical therapeuticsDOI：10.1016/j.clinthera.2019.06.004
Humanistic Burden of Refractory and Nonrefractory Chronic Idiopathic Urticaria: A Real-world Study in the United States.
来源期刊：Clinical therapeuticsDOI：10.1016/j.clinthera.2018.12.004
Automation With Intelligence in Drug Research.
来源期刊：Clinical therapeuticsDOI：10.1016/j.clinthera.2019.09.002
Ezetimibe and Rosuvastatin Combination Treatment Can Reduce the Dose of Rosuvastatin Without Compromising Its Lipid-Lowering Efficacy.
来源期刊：Clinical therapeuticsDOI：10.1016/j.clinthera.2019.10.010
Clinical and Economic Analysis of Morphine Versus Fentanyl in Managing Ventilated Neonates With Respiratory Distress Syndrome in the Intensive Care Setting.
来源期刊：Clinical therapeuticsDOI：10.1016/j.clinthera.2019.02.009
Associations Between Autonomic and Orthostatic Self-report and Physician Ratings of Orthostatic Intolerance in Youth.
来源期刊：Clinical therapeuticsDOI：10.1016/j.clinthera.2019.02.010
Analyzing missing data in perinatal pharmacoepidemiology research: Methodological considerations to limit the risk of bias.
来源期刊：Clinical therapeuticsDOI：10.1016/j.clinthera.2019.11.003
Pharmacokinetics and Pharmacodynamics of Once-daily Prolonged-release Tacrolimus in Liver Transplant Recipients.
来源期刊：Clinical therapeuticsDOI：10.1016/j.clinthera.2019.03.006
A Cost-effectiveness Analysis of Albumin in Septic Shock: A Patient-level Data Analysis.
来源期刊：Clinical therapeuticsDOI：10.1016/j.clinthera.2019.08.023
Computational Drug Discovery in Chemotherapy-induced Alopecia via Text Mining and Biomedical Databases.
来源期刊：Clinical therapeuticsDOI：10.1016/j.clinthera.2019.04.003
Association Between Exposure of Ipratropium and Salmeterol and Diagnosis of Multiple Sclerosis: A Matched Case-control Study.
来源期刊：Clinical therapeuticsDOI：10.1016/j.clinthera.2019.04.039
Hypnosis Program Effectiveness in a 12-week Home Care Intervention To Manage Chronic Pain in Elderly Women.
来源期刊：Clinical therapeuticsDOI：10.1016/j.clinthera.2019.11.007
Coadministration of Sublingual Immunotherapy Tablets and Management of Potential Adverse Effects: Austrian, German, and Swiss Expert Recommendations.
来源期刊：Clinical therapeuticsDOI：10.1016/j.clinthera.2019.07.005
Risk Factors of QTc Prolongation in Women With Hormone Receptor‒positive/Human Epidermal Growth Factor Receptor 2‒negative Metastatic Breast Cancer: A Retrospective Analysis of Health Care Claims Data.
来源期刊：Clinical therapeuticsDOI：10.1016/j.clinthera.2019.01.012
A Pooled Analysis of the Safety and Efficacy of Iclaprim Versus Vancomycin for the Treatment of Acute Bacterial Skin and Skin Structure Infections in Patients With Intravenous Drug Use: Phase 3 REVIVE Studies.
来源期刊：Clinical therapeuticsDOI：10.1016/j.clinthera.2019.04.004
Comparative Bioavailability Study of a New Orodispersible Formulation of Ibuprofen Versus Two Existing Oral Tablet Formulations in Healthy Male and Female Volunteers.
来源期刊：Clinical therapeuticsDOI：10.1016/j.clinthera.2019.04.040
Impact of Beta-Lactam Allergy on Treatment of Outpatient Infections.
来源期刊：Clinical therapeuticsDOI：10.1016/j.clinthera.2019.10.001
Selective Serotonin Reuptake Inhibitor Use and Risk of Arrhythmia: A Nationwide, Population-Based Cohort Study.
来源期刊：Clinical therapeuticsDOI：10.1016/j.clinthera.2019.04.023
High Pyridine Generation in Ceftazidime-Icodextrin Admixtures Used to Treat Peritoneal Dialysis-Associated Peritonitis.
来源期刊：Clinical therapeuticsDOI：10.1016/j.clinthera.2019.08.021
Host-Pathogen Interactions.
来源期刊：Clinical therapeuticsDOI：10.1016/j.clinthera.2019.08.017
