Translating molecular bioscience and experimental research into medical insights, Clinical Science offers multi-disciplinary coverage and clinical perspectives to advance human health.Its international Editorial Board is charged with selecting peer-reviewed original papers of the highest scientific merit covering the broad spectrum of biomedical specialities including, although not exclusively:Cardiovascular systemCerebrovascular systemGastrointestinal tract and liverGenomic medicineInfection and immunityInflammationOncologyMetabolismEndocrinology and nutritionNephrologyCirculationRespiratory systemVascular biologyMolecular pathology.
《临床科学》将分子生物科学和实验研究转化为医学见解，提供多学科覆盖和临床视角，以促进人类健康。其国际编辑委员会负责选择涵盖广泛生物医学专业的最高科学价值的同行评审原创论文，包括但不限于：心血管系统脑血管系统胃肠道和肝脏基因组医学感染和免疫炎症肿瘤代谢内分泌和营养肾脏病循环呼吸系统血管生物学分子病理学。
Fetal programming and the angiotensin-(1-7) axis: a review of the experimental and clinical data.
来源期刊：Clinical scienceDOI：10.1042/CS20171550
MicroRNAs and other non-coding RNAs in adipose tissue and obesity: emerging roles as biomarkers and therapeutic targets.
来源期刊：Clinical scienceDOI：10.1042/CS20180890
CircRASSF2 promotes laryngeal squamous cell carcinoma progression by regulating the miR-302b-3p/IGF-1R axis.
来源期刊：Clinical scienceDOI：10.1042/CS20190110
New therapeutic targets for the prevention of infectious acute exacerbations of COPD: role of epithelial adhesion molecules and inflammatory pathways.
来源期刊：Clinical scienceDOI：10.1042/CS20181009
Empagliflozin prevents cardiomyopathy via sGC-cGMP-PKG pathway in type 2 diabetes mice.
来源期刊：Clinical scienceDOI：10.1042/CS20190585
Transforming growth factor β (TGFβ) and related molecules in chronic kidney disease (CKD).
来源期刊：Clinical scienceDOI：10.1042/CS20180438
GPR120 protects lipotoxicity-induced pancreatic β-cell dysfunction through regulation of PDX1 expression and inhibition of islet inflammation.
来源期刊：Clinical scienceDOI：10.1042/CS20180836
Suppression of miRNA let-7i-5p promotes cardiomyocyte proliferation and repairs heart function post injury by targetting CCND2 and E2F2.
来源期刊：Clinical scienceDOI：10.1042/CS20181002
Chemerin-9, a potent agonist of chemerin receptor (ChemR23), prevents atherogenesis.
来源期刊：Clinical scienceDOI：10.1042/CS20190336
Elafibranor interrupts adipose dysfunction-mediated gut and liver injury in mice with alcoholic steatohepatitis.
来源期刊：Clinical scienceDOI：10.1042/CS20180873
HEG1 indicates poor prognosis and promotes hepatocellular carcinoma invasion, metastasis, and EMT by activating Wnt/β-catenin signaling.
来源期刊：Clinical scienceDOI：10.1042/CS20190225
SPARC is required for the maintenance of glucose homeostasis and insulin secretion in mice.
来源期刊：Clinical scienceDOI：10.1042/CS20180714
Trained immunity and diabetic vascular disease.
来源期刊：Clinical scienceDOI：10.1042/CS20180905
The vermiform appendix: an immunological organ sustaining a microbiome inoculum.
来源期刊：Clinical scienceDOI：10.1042/CS20180956
Involvement of serum amyloid A1 in the rupture of fetal membranes through induction of collagen I degradation.
来源期刊：Clinical scienceDOI：10.1042/CS20180950
Ovarian cancer-derived exosomes promote tumor metastasis in vivo an effect modulated by the invasiveness capacity of their originating cells.
来源期刊：Clinical scienceDOI：10.1042/CS20190082
DDAH-2 alleviates contrast medium iopromide-induced acute kidney injury through nitric oxide synthase.
来源期刊：Clinical scienceDOI：10.1042/CS20190455
Effect of Mycophenolate and Rapamycin on Renal Fibrosis in Lupus Nephritis.
来源期刊：Clinical scienceDOI：10.1042/CS20190536
Endogenous hydrogen sulfide sulfhydrates IKKβ at cysteine 179 to control pulmonary artery endothelial cell inflammation.
来源期刊：Clinical scienceDOI：10.1042/cs20190514
SETD3 is regulated by a couple of microRNAs and plays opposing roles in proliferation and metastasis of hepatocellular carcinoma.
来源期刊：Clinical scienceDOI：10.1042/cs20190666
Targeting Bromodomain-containing proteins to prevent spontaneous preterm birth.
来源期刊：Clinical scienceDOI：10.1042/CS20190919
ZEB1-AS1 is associated with poor prognosis in non-small-cell lung cancer and influences cell migration and apoptosis by repressing ID1.
来源期刊：Clinical scienceDOI：10.1042/CS20180983
Adipocytes initiates an adipose-cerebral-peripheral sympathetic reflex to induce insulin resistance during high fat feeding.
来源期刊：Clinical scienceDOI：10.1042/CS20190412
Endothelial cell-derived small extracellular vesicles suppress cutaneous wound healing through regulating fibroblasts autophagy.
来源期刊：Clinical scienceDOI：10.1042/CS20190008
Impaired l-arginine-nitric oxide pathway contributes to the pathogenesis of resistant hypertension.
来源期刊：Clinical scienceDOI：10.1042/cs20190851
Hyperglycemia-induced transcriptional regulation of ROCK1 and TGM2 expression is involved in small artery remodeling in obese diabetic Göttingen Minipigs.
来源期刊：Clinical scienceDOI：10.1042/CS20191066
Particulate matter exposure aggravates osteoarthritis severity.
来源期刊：Clinical scienceDOI：10.1042/cs20190458
Down-regulation of placental Cdc42 and Rac1 links mTORC2 inhibition to decreased trophoblast amino acid transport in human intrauterine growth restriction.
来源期刊：Clinical scienceDOI：10.1042/CS20190794
First identification of PODXL nonsense mutations in autosomal dominant focal segmental glomerulosclerosis.
来源期刊：Clinical scienceDOI：10.1042/CS20180676
Depletion of CD11c+ dendritic cells in apolipoprotein E-deficient mice limits angiotensin II-induced abdominal aortic aneurysm formation and growth.
来源期刊：Clinical scienceDOI：10.1042/cs20190924
MiR-33a is a therapeutic target in SPG4-related hereditary spastic paraplegia human neurons.
来源期刊：Clinical scienceDOI：10.1042/CS20180980
Processes exacerbating apoptosis in non-alcoholic steatohepatitis.
来源期刊：Clinical scienceDOI：10.1042/CS20190068
Creating a potential diagnostic for prostate cancer risk stratification (InformMDx™) by translating novel scientific discoveries concerning cAMP degrading phosphodiesterase-4D7 (PDE4D7).
来源期刊：Clinical scienceDOI：10.1042/CS20180519
Role of Orexin-B/Orexin 2 receptor in myocardial protection.
来源期刊：Clinical scienceDOI：10.1042/CS20181036
Application of nintedanib and other potential anti-fibrotic agents in fibrotic diseases.
来源期刊：Clinical scienceDOI：10.1042/CS20190249
Impact of obesity-induced type 2 diabetes on long-term outcomes following stroke.
来源期刊：Clinical scienceDOI：10.1042/CS20190492
Relationship between renin-angiotensin-aldosterone system and renal Kir5.1 channels.
来源期刊：Clinical scienceDOI：10.1042/cs20190876
A novel function for HEG1 in promoting metastasis in hepatocellular carcinoma.
来源期刊：Clinical scienceDOI：10.1042/cs20190704
Neutral endopeptidase inhibitors blunt kidney fibrosis by reducing myofibroblast formation.
来源期刊：Clinical scienceDOI：10.1042/CS20180882
The human duodenal mucosa harbors all components for a local renin angiotensin system.
来源期刊：Clinical scienceDOI：10.1042/CS20180877
Sexual dimorphism of miRNA signatures in feto-placental endothelial cells is associated with altered barrier function and actin organisation.
来源期刊：Clinical scienceDOI：10.1042/cs20190379
Cyclosporine A promotes the therapeutic effect of mesenchymal stem cells on transplantation reaction.
来源期刊：Clinical scienceDOI：10.1042/cs20190294
Is there a role for autophagy in ascending aortopathy associated with tricuspid or bicuspid aortic valve?
来源期刊：Clinical scienceDOI：10.1042/CS20181092
Mitochondrial protein 18 is a positive apoptotic regulator in cardiomyocytes under oxidative stress.
来源期刊：Clinical scienceDOI：10.1042/CS20190125
Elevated level of circulatory sTLT1 induces inflammation through SYK/MEK/ERK signalling in coronary artery disease.
来源期刊：Clinical scienceDOI：10.1042/CS20190999
Specialized pro-resolving mediators in diabetes: novel therapeutic strategies.
来源期刊：Clinical scienceDOI：10.1042/cs20190067
Lack of adipose-specific hexose-6-phosphate dehydrogenase causes inactivation of adipose glucocorticoids and improves metabolic phenotype in mice.
来源期刊：Clinical scienceDOI：10.1042/cs20190679
Overexpression of the aryl hydrocarbon receptor nuclear translocator partially rescues fetoplacental angiogenesis in severe fetal growth restriction.
来源期刊：Clinical scienceDOI：10.1042/CS20190381
Electrolyte transport in the renal collecting duct and its regulation by the renin-angiotensin-aldosterone system.
来源期刊：Clinical scienceDOI：10.1042/CS20180194
Lipid metabolism participates in human membranous nephropathy identified by whole-genome gene expression profiling.
来源期刊：Clinical scienceDOI：10.1042/CS20181110
