Clinical Pharmacology & Therapeutics (CPT) is the authoritative cross-disciplinary journal in experimental and clinical medicine devoted to publishing advances in the nature, action, efficacy, and evaluation of therapeutics. CPT welcomes original Articles in the emerging areas of translational, predictive and personalized medicine; new therapeutic modalities including gene and cell therapies; pharmacogenomics, proteomics and metabolomics; bioinformation and applied systems biology complementing areas of pharmacokinetics and pharmacodynamics, human investigation and clinical trials, pharmacovigilence, pharmacoepidemiology, pharmacometrics, and population pharmacology.
临床药理学与治疗学（CPT）是实验和临床医学领域的权威性交叉学科期刊，致力于发表治疗学的性质、作用、疗效和评价方面的进展。CPT欢迎转化、预测和个性化医学新兴领域的原创文章;包括基因和细胞治疗的新治疗模式;药物基因组学、蛋白质组学和代谢组学;生物信息学和应用系统生物学补充了药物动力学和药效学、人体研究和临床试验、药物警戒、药物流行病学、药物计量学和群体药理学等领域。
Assessment of an In Silico Mechanistic Model for Proarrhythmia Risk Prediction Under the CiPA Initiative
来源期刊：Clinical Pharmacology and TherapeuticsDOI：10.1002/cpt.1184
Real‐World Data for Regulatory Decision Making: Challenges and Possible Solutions for Europe
来源期刊：Clinical Pharmacology and TherapeuticsDOI：10.1002/cpt.1426
M281, an Anti‐FcRn Antibody: Pharmacodynamics, Pharmacokinetics, and Safety Across the Full Range of IgG Reduction in a First‐in‐Human Study
来源期刊：Clinical Pharmacology and TherapeuticsDOI：10.1002/cpt.1276
Development of the PGx‐Passport: A Panel of Actionable Germline Genetic Variants for Pre‐Emptive Pharmacogenetic Testing
来源期刊：Clinical Pharmacology and TherapeuticsDOI：10.1002/cpt.1489
General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico Strategy
来源期刊：Clinical Pharmacology and TherapeuticsDOI：10.1002/cpt.1647
Are Novel, Nonrandomized Analytic Methods Fit for Decision Making? The Need for Prospective, Controlled, and Transparent Validation
来源期刊：Clinical Pharmacology and TherapeuticsDOI：10.1002/cpt.1638
Pharmacogenomics of Vincristine‐Induced Peripheral Neuropathy Implicates Pharmacokinetic and Inherited Neuropathy Genes
来源期刊：Clinical Pharmacology and TherapeuticsDOI：10.1002/cpt.1179
Abemaciclib Inhibits Renal Tubular Secretion Without Changing Glomerular Filtration Rate
来源期刊：Clinical Pharmacology and TherapeuticsDOI：10.1002/cpt.1296
Physiologically‐Based Pharmacokinetic Models for Evaluating Membrane Transporter Mediated Drug–Drug Interactions: Current Capabilities, Case Studies, Future Opportunities, and Recommendations
来源期刊：Clinical Pharmacology and TherapeuticsDOI：10.1002/cpt.1693
Genomewide Association Study of Statin‐Induced Myopathy in Patients Recruited Using the UK Clinical Practice Research Datalink
来源期刊：Clinical Pharmacology and TherapeuticsDOI：10.1002/cpt.1557
A Comparison of EMA and FDA Decisions for New Drug Marketing Applications 2014–2016: Concordance, Discordance, and Why
来源期刊：Clinical Pharmacology and TherapeuticsDOI：10.1002/cpt.1565
A PK/PD Analysis of Circulating Biomarkers and Their Relationship to Tumor Response in Atezolizumab‐Treated non‐small Cell Lung Cancer Patients
来源期刊：Clinical Pharmacology and TherapeuticsDOI：10.1002/cpt.1198
Examining the Use of Real‐World Evidence in the Regulatory Process
来源期刊：Clinical Pharmacology and TherapeuticsDOI：10.1002/cpt.1658
Pharmacogenomics Clinical Annotation Tool (PharmCAT)
来源期刊：Clinical Pharmacology and TherapeuticsDOI：10.1002/cpt.1568
Calling Star Alleles With Stargazer in 28 Pharmacogenes With Whole Genome Sequences
来源期刊：Clinical Pharmacology and TherapeuticsDOI：10.1002/cpt.1552
Exposure–Response Analyses of Upadacitinib Efficacy in Phase II Trials in Rheumatoid Arthritis and Basis for Phase III Dose Selection
来源期刊：Clinical Pharmacology and TherapeuticsDOI：10.1002/cpt.1543
Vedolizumab for Inflammatory Bowel Disease: Two‐Year Results of the Initiative on Crohn and Colitis (ICC) Registry, A Nationwide Prospective Observational Cohort Study
来源期刊：Clinical Pharmacology and TherapeuticsDOI：10.1002/cpt.1712
Pharmacokinetics, Safety, and Tolerability of Tezepelumab (AMG 157) in Healthy and Atopic Dermatitis Adult Subjects
来源期刊：Clinical Pharmacology and TherapeuticsDOI：10.1002/cpt.1401
Relationship Between Benralizumab Exposure and Efficacy for Patients With Severe Eosinophilic Asthma
来源期刊：Clinical Pharmacology and TherapeuticsDOI：10.1002/cpt.1371
Pediatric Anthracycline‐Induced Cardiotoxicity: Mechanisms, Pharmacogenomics, and Pluripotent Stem‐Cell Modeling
来源期刊：Clinical Pharmacology and TherapeuticsDOI：10.1002/cpt.1311
Evaluation of the Effects of a Monthly Buprenorphine Depot Subcutaneous Injection on QT Interval During Treatment for Opioid Use Disorder
来源期刊：Clinical Pharmacology and TherapeuticsDOI：10.1002/cpt.1406
Single Therapeutic and Supratherapeutic Doses of Ubrogepant Do Not Affect Cardiac Repolarization in Healthy Adults: Results From a Randomized Trial
来源期刊：Clinical Pharmacology and TherapeuticsDOI：10.1002/cpt.1696
Exposure–Response Relationships for Efficacy and Safety of Risankizumab in Phase II and III Trials in Psoriasis Patients
来源期刊：Clinical Pharmacology and TherapeuticsDOI：10.1002/cpt.1594
A Structured Preapproval and Postapproval Comparative Study Design Framework to Generate Valid and Transparent Real‐World Evidence for Regulatory Decisions
来源期刊：Clinical Pharmacology and TherapeuticsDOI：10.1002/cpt.1480
Small But Mighty: The Use of Real‐World Evidence to Inform Precision Medicine
来源期刊：Clinical Pharmacology and TherapeuticsDOI：10.1002/cpt.1466
Improving the Safety of Medicines in the European Union: From Signals to Action
来源期刊：Clinical Pharmacology and TherapeuticsDOI：10.1002/cpt.1678
Repurposing of Diagnostic Whole Exome Sequencing Data of 1,583 Individuals for Clinical Pharmacogenetics
来源期刊：Clinical Pharmacology and TherapeuticsDOI：10.1002/cpt.1665
Digital Learning to Improve Safe and Effective Prescribing: A Systematic Review
来源期刊：Clinical Pharmacology and TherapeuticsDOI：10.1002/cpt.1549
Enantiospecific Pharmacogenomics of Fluvastatin
来源期刊：Clinical Pharmacology and TherapeuticsDOI：10.1002/cpt.1463
Genomic Variation and Pharmacokinetics in Old Age: A Quantitative Review of Age‐ vs. Genotype‐Related Differences
来源期刊：Clinical Pharmacology and TherapeuticsDOI：10.1002/cpt.1057
Dual Roles for the TSPYL Family in Mediating Serotonin Transport and the Metabolism of Selective Serotonin Reuptake Inhibitors in Patients with Major Depressive Disorder
来源期刊：Clinical Pharmacology and TherapeuticsDOI：10.1002/cpt.1692
Model‐Informed Drug Development for Ixazomib, an Oral Proteasome Inhibitor
来源期刊：Clinical Pharmacology and TherapeuticsDOI：10.1002/cpt.1047
Risk of Myocardial Infarction Among New Users of Calcium Supplements Alone or Combined With Vitamin D: A Population‐Based Case‐Control Study
来源期刊：Clinical Pharmacology and TherapeuticsDOI：10.1002/cpt.1636
The Missing Reality of Real Life in Real‐World Evidence
来源期刊：Clinical Pharmacology and TherapeuticsDOI：10.1002/cpt.1465
Pharmacogenomics in Practice
来源期刊：Clinical Pharmacology and TherapeuticsDOI：10.1002/cpt.1600
Real‐World Data: An Unrealized Opportunity in Global Health?
来源期刊：Clinical Pharmacology and TherapeuticsDOI：10.1002/cpt.1476
Neural architecture influences rTMS-induced functional change: a DTI and FMRI study of cue-reactivity modulation in alcohol users.
来源期刊：Clinical pharmacology and therapeuticsDOI：10.1002/cpt.1545
Association of Statin and Its Lipophilicity With Cardiovascular Events in Patients Receiving Chronic Dialysis
来源期刊：Clinical Pharmacology and TherapeuticsDOI：10.1002/cpt.1722
Comparison of Different Strategies to Measure Medication Adherence via Claims Data in Patients With Chronic Heart Failure
来源期刊：Clinical Pharmacology and TherapeuticsDOI：10.1002/cpt.1378
The Current and Future Potential of TMS-EEG in Psychiatry.
来源期刊：Clinical pharmacology and therapeuticsDOI：10.1002/cpt.1541
Anastrozole Aromatase Inhibitor Plasma Drug Concentration Genome‐Wide Association Study: Functional Epistatic Interaction Between SLC38A7 and ALPPL2
来源期刊：Clinical Pharmacology and TherapeuticsDOI：10.1002/cpt.1359
Interchangeability of Generics—Experiences and Outlook Toward Pharmacokinetics Variability and Generic‐Generic Substitution
来源期刊：Clinical Pharmacology and TherapeuticsDOI：10.1002/cpt.1250
Broad‐Spectrum Profiling of Drug Safety via Learning Complex Network
来源期刊：Clinical Pharmacology and TherapeuticsDOI：10.1002/cpt.1750
“Thorough QT/QTc in a Dish”: Can Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes Predict Thorough QT Outcomes?
来源期刊：Clinical Pharmacology and TherapeuticsDOI：10.1002/cpt.1384
Trials in “True” Dyslipidemic Patients Are Urged to Reconsider Comprehensive Lipid Management as a Means to Reduce Residual Cardiovascular Risk
来源期刊：Clinical Pharmacology and TherapeuticsDOI：10.1002/cpt.1436
Are EMA, FDA and other international regulators talking to each other?
来源期刊：Clinical pharmacology and therapeuticsDOI：10.1002/cpt.1617
A Patient‐Centric Model for Discontinuation of a Single‐Sourced Approved Drug
来源期刊：Clinical Pharmacology and TherapeuticsDOI：10.1002/cpt.1411
A new liver eQTL map from 1,183 individuals provides evidence for novel eQTLs of drug response, metabolic and sex-biased phenotypes.
来源期刊：Clinical pharmacology and therapeuticsDOI：10.1002/cpt.1751
A Framework Proposal to Follow‐Up on Preclinical Convulsive Signals of a New Molecular Entity in First‐in‐Human Studies Using Electroencephalographic Monitoring
来源期刊：Clinical Pharmacology and TherapeuticsDOI：10.1002/cpt.1455
Path Toward Proactive Therapy for Patent Ductus Arteriosus
来源期刊：Clinical Pharmacology and TherapeuticsDOI：10.1002/cpt.1583
