APS (Acta Pharmacologica Sinica) encourages submissions from all areas of pharmacology and the life sciences. Topics of particular interest include, but are not limited to, anticancer pharmacology, cardiovascular and pulmonary pharmacology, clinical pharmacology, drug discovery, gastrointestinal and hepatic pharmacology, genitourinary, renal and endocrine pharmacology, immunopharmacology and inflammation, molecular and cellular pharmacology, neuropharmacology, pharmaceutics and pharmacokinetics.
美国药理学学报（APS）鼓励来自药理学和生命科学各个领域的投稿。特别感兴趣的主题包括但不限于抗癌药理学、心血管和肺药理学、临床药理学、药物发现、胃肠和肝脏药理学、泌尿生殖、肾脏和内分泌药理学、免疫药理学和炎症、分子和细胞药理学、神经药理学、药剂学和药代动力学。
Curculigoside facilitates fear extinction and prevents depression-like behaviors in a mouse learned helplessness model through increasing hippocampal BDNF
来源期刊：Acta Pharmacologica SinicaDOI：10.1038/s41401-019-0238-4
Cannabis, cannabinoid receptors, and endocannabinoid system: yesterday, today, and tomorrow
来源期刊：Acta Pharmacologica SinicaDOI：10.1038/s41401-019-0210-3
Inhibition of M2-like macrophages by all-trans retinoic acid prevents cancer initiation and stemness in osteosarcoma cells
来源期刊：Acta Pharmacologica SinicaDOI：10.1038/s41401-019-0262-4
Honokiol inhibits breast cancer cell metastasis by blocking EMT through modulation of Snail/Slug protein translation
来源期刊：Acta Pharmacologica SinicaDOI：10.1038/s41401-019-0240-x
Kanglexin, a novel anthraquinone compound, protects against myocardial ischemic injury in mice by suppressing NLRP3 and pyroptosis
来源期刊：Acta Pharmacologica SinicaDOI：10.1038/s41401-019-0307-8
Costunolide alleviates HKSA-induced acute lung injury via inhibition of macrophage activation
来源期刊：Acta Pharmacologica SinicaDOI：10.1038/s41401-018-0192-6
Increased BBB permeability contributes to EGCG-caused cognitive function improvement in natural aging rats: pharmacokinetic and distribution analyses
来源期刊：Acta Pharmacologica SinicaDOI：10.1038/s41401-019-0243-7
Interplay between Alzheimer’s disease and global glucose metabolism revealed by the metabolic profile alterations of pancreatic tissue and serum in APP/PS1 transgenic mice
来源期刊：Acta Pharmacologica SinicaDOI：10.1038/s41401-019-0239-3
Diabetes inhibits corneal epithelial cell migration and tight junction formation in mice and human via increasing ROS and impairing Akt signaling
来源期刊：Acta Pharmacologica SinicaDOI：10.1038/s41401-019-0223-y
TRAIL-based gene delivery and therapeutic strategies
来源期刊：Acta Pharmacologica SinicaDOI：10.1038/s41401-019-0287-8
Artesunate attenuates LPS-induced osteoclastogenesis by suppressing TLR4/TRAF6 and PLCγ1-Ca2+-NFATc1 signaling pathway
来源期刊：Acta Pharmacologica SinicaDOI：10.1038/s41401-019-0289-6
Histone methyltransferase NSD2 mediates the survival and invasion of triple-negative breast cancer cells via stimulating ADAM9-EGFR-AKT signaling
来源期刊：Acta Pharmacologica SinicaDOI：10.1038/s41401-018-0199-z
Ganoderic acid hinders renal fibrosis via suppressing the TGF-β/Smad and MAPK signaling pathways
来源期刊：Acta Pharmacologica SinicaDOI：10.1038/s41401-019-0324-7
RNF6 promotes myeloma cell proliferation and survival by inducing glucocorticoid receptor polyubiquitination
来源期刊：Acta Pharmacologica SinicaDOI：10.1038/s41401-019-0309-6
Intravenous formulation of Panax notoginseng root extract: human pharmacokinetics of ginsenosides and potential for perpetrating drug interactions
来源期刊：Acta Pharmacologica SinicaDOI：10.1038/s41401-019-0273-1
Predicted secreted protein analysis reveals synaptogenic function of Clstn3 during WAT browning and BAT activation in mice
来源期刊：Acta Pharmacologica SinicaDOI：10.1038/s41401-019-0211-2
Sevoflurane promotes migration, invasion, and colony-forming ability of human glioblastoma cells possibly via increasing the expression of cell surface protein 44
来源期刊：Acta Pharmacologica SinicaDOI：10.1038/s41401-019-0221-0
Inactivation of TSC1 promotes epithelial-mesenchymal transition of renal tubular epithelial cells in mouse diabetic nephropathy
来源期刊：Acta Pharmacologica SinicaDOI：10.1038/s41401-019-0244-6
mTORC1 inhibitor RAD001 (everolimus) enhances non-small cell lung cancer cell radiosensitivity in vitro via suppressing epithelial–mesenchymal transition
来源期刊：Acta Pharmacologica SinicaDOI：10.1038/s41401-019-0215-y
α1-AR overactivation induces cardiac inflammation through NLRP3 inflammasome activation
来源期刊：Acta Pharmacologica SinicaDOI：10.1038/s41401-019-0305-x
A novel gemcitabine derivative-loaded liposome with great pancreas-targeting ability
来源期刊：Acta Pharmacologica SinicaDOI：10.1038/s41401-019-0227-7
Xanthatin induces glioma cell apoptosis and inhibits tumor growth via activating endoplasmic reticulum stress-dependent CHOP pathway
来源期刊：Acta Pharmacologica SinicaDOI：10.1038/s41401-019-0318-5
Mebendazole elicits potent antimyeloma activity by inhibiting the USP5/c-Maf axis
来源期刊：Acta Pharmacologica SinicaDOI：10.1038/s41401-019-0249-1
A novel compound AB38b attenuates oxidative stress and ECM protein accumulation in kidneys of diabetic mice through modulation of Keap1/Nrf2 signaling
来源期刊：Acta Pharmacologica SinicaDOI：10.1038/s41401-019-0297-6
Minocycline protects against myocardial ischemia/reperfusion injury in rats by upregulating MCPIP1 to inhibit NF-κB activation
来源期刊：Acta Pharmacologica SinicaDOI：10.1038/s41401-019-0214-z
Advances in the development of imaging probes and aggregation inhibitors for alpha-synuclein
来源期刊：Acta Pharmacologica SinicaDOI：10.1038/s41401-019-0304-y
Establishment of a mouse model of cancer cachexia with spleen deficiency syndrome and the effects of atractylenolide I
来源期刊：Acta Pharmacologica SinicaDOI：10.1038/s41401-019-0275-z
Associating 197 Chinese herbal medicine with drug targets and diseases using the similarity ensemble approach
来源期刊：Acta Pharmacologica SinicaDOI：10.1038/s41401-019-0306-9
Discovery and characterization of natural products as novel indoleamine 2,3-dioxygenase 1 inhibitors through high-throughput screening
来源期刊：Acta Pharmacologica SinicaDOI：10.1038/s41401-019-0246-4
Cathepsin L induced PC-12 cell apoptosis via activation of B-Myb and regulation of cell cycle proteins
来源期刊：Acta Pharmacologica SinicaDOI：10.1038/s41401-019-0286-9
Structure-based design of a hyperthermostable AgUricase for hyperuricemia and gout therapy
来源期刊：Acta Pharmacologica SinicaDOI：10.1038/s41401-019-0269-x
[1,2,4]Triazolo[1,5-a]pyrimidine derivative (Mol-5) is a new NS5-RdRp inhibitor of DENV2 proliferation and DENV2-induced inflammation
来源期刊：Acta Pharmacologica SinicaDOI：10.1038/s41401-019-0316-7
RepSox, a small molecule inhibitor of the TGFβ receptor, induces brown adipogenesis and browning of white adipocytes
来源期刊：Acta Pharmacologica SinicaDOI：10.1038/s41401-019-0264-2
Cocaine potently blocks neuronal α3β4 nicotinic acetylcholine receptors in SH-SY5Y cells
来源期刊：Acta Pharmacologica SinicaDOI：10.1038/s41401-019-0276-y
A new recombinant MS-superoxide dismutase alleviates 5-fluorouracil-induced intestinal mucositis in mice
来源期刊：Acta Pharmacologica SinicaDOI：10.1038/s41401-019-0295-8
DL0410 ameliorates cognitive deficits in APP/PS1 transgenic mice by promoting synaptic transmission and reducing neuronal loss
来源期刊：Acta Pharmacologica SinicaDOI：10.1038/s41401-019-0312-y
Isosibiricin inhibits microglial activation by targeting the dopamine D1/D2 receptor-dependent NLRP3/caspase-1 inflammasome pathway
来源期刊：Acta Pharmacologica SinicaDOI：10.1038/s41401-019-0296-7
C10ORF12 modulates PRC2 histone methyltransferase activity and H3K27me3 levels
来源期刊：Acta Pharmacologica SinicaDOI：10.1038/s41401-019-0247-3
Urotensin II and urantide exert opposite effects on the cellular components of atherosclerotic plaque in hypercholesterolemic rabbits
来源期刊：Acta Pharmacologica SinicaDOI：10.1038/s41401-019-0315-8
Integrating yeast chemical genomics and mammalian cell pathway analysis
来源期刊：Acta Pharmacologica SinicaDOI：10.1038/s41401-019-0231-y
Prostaglandin E1 attenuates high glucose-induced apoptosis in proximal renal tubular cells by inhibiting the JNK/Bim pathway
来源期刊：Acta Pharmacologica SinicaDOI：10.1038/s41401-019-0314-9
The inhibitory mechanism of aurintricarboxylic acid targeting serine/threonine phosphatase Stp1 in Staphylococcus aureus: insights from molecular dynamics simulations
来源期刊：Acta Pharmacologica SinicaDOI：10.1038/s41401-019-0216-x
Metoprolol prevents neuronal dendrite remodeling in a canine model of chronic obstructive sleep apnea
来源期刊：Acta Pharmacologica SinicaDOI：10.1038/s41401-019-0323-8
Characteristics of β-oxidative and reductive metabolism on the acyl side chain of cinnamic acid and its analogues in rats
来源期刊：Acta Pharmacologica SinicaDOI：10.1038/s41401-019-0218-8
Propofol affects mouse embryonic fibroblast survival and proliferation in vitro via ATG5- and calcium-dependent regulation of autophagy
来源期刊：Acta Pharmacologica SinicaDOI：10.1038/s41401-019-0303-z
Author Correction: Plumbagin attenuates cancer cell growth and osteoclast formation in the bone microenvironment of mice
来源期刊：Acta Pharmacologica SinicaDOI：10.1038/s41401-019-0252-6
Small molecule IVQ, as a prodrug of gluconeogenesis inhibitor QVO, efficiently ameliorates glucose homeostasis in type 2 diabetic mice
来源期刊：Acta Pharmacologica SinicaDOI：10.1038/s41401-018-0208-2
Publisher Correction: Inflammation-activated CXCL16 pathway contributes to tubulointerstitial injury in mouse diabetic nephropathy
来源期刊：Acta Pharmacologica SinicaDOI：10.1038/s41401-019-0226-8
23,24-Dihydrocucurbitacin B promotes lipid clearance by dual transcriptional regulation of LDLR and PCSK9
来源期刊：Acta Pharmacologica SinicaDOI：10.1038/s41401-019-0274-0
Clcn3 deficiency ameliorates high-fat diet-induced obesity and adipose tissue macrophage inflammation in mice
来源期刊：Acta Pharmacologica SinicaDOI：10.1038/s41401-019-0229-5
