Clinical Colorectal Cancer is a peer-reviewed, quarterly journal that publishes original articles describing various aspects of clinical and translational research of gastrointestinal cancers. Clinical Colorectal Cancer is devoted to articles on detection, diagnosis, prevention, and treatment of colorectal, pancreatic, liver, and other gastrointestinal cancers. The main emphasis is on recent scientific developments in all areas related to gastrointestinal cancers. Specific areas of interest include clinical research and mechanistic approaches; drug sensitivity and resistance; gene and antisense therapy; pathology, markers, and prognostic indicators; chemoprevention strategies; multimodality therapy; and integration of various approaches.
《临床结直肠癌》是一份同行评审的季刊，发表描述胃肠癌临床和转化研究各个方面的原创文章。《临床结直肠癌》致力于结直肠癌、胰腺癌、肝癌和其他胃肠癌的检测、诊断、预防和治疗。主要重点是最近在与胃肠道癌症有关的所有领域的科学发展。感兴趣的具体领域包括临床研究和机械方法;药物敏感性和耐药性;基因和反义治疗;病理学、标志物和预后指标;化学预防策略;综合疗法;以及各种方法的综合。
Stromal PD‐1/PD‐L1 Expression Predicts Outcome in Colon Cancer Patients
来源期刊：Clinical Colorectal CancerDOI：10.1016/j.clcc.2018.09.007
Impact of Sex on Chemotherapy Toxicity and Efficacy Among Patients With Metastatic Colorectal Cancer: Pooled Analysis of 5 Randomized Trials.
来源期刊：Clinical colorectal cancerDOI：10.1016/j.clcc.2018.12.006
Bolus 5‐fluorouracil (5‐FU) In Combination With Oxaliplatin Is Safe and Well Tolerated in Patients Who Experienced Coronary Vasospasm With Infusional 5‐FU or Capecitabine
来源期刊：Clinical Colorectal CancerDOI：10.1016/j.clcc.2018.09.006
5‐Fluorouracil‐related Cardiotoxicity; Findings From Five Randomized Studies of 5‐Fluorouracil‐based Regimens in Metastatic Colorectal Cancer
来源期刊：Clinical Colorectal CancerDOI：10.1016/j.clcc.2018.10.006
Pattern, Stage, and Time of Recurrent Colorectal Cancer After Curative Surgery.
来源期刊：Clinical colorectal cancerDOI：10.1016/j.clcc.2019.01.003
Review: Pathology and Its Clinical Relevance of Mucinous Appendiceal Neoplasms and Pseudomyxoma Peritonei.
来源期刊：Clinical colorectal cancerDOI：10.1016/j.clcc.2018.11.007
A Genomic Analysis Workflow for Colorectal Cancer Precision Oncology.
来源期刊：Clinical colorectal cancerDOI：10.1016/J.CLCC.2019.02.008
Phase II Study of Tivantinib and Cetuximab in Patients With KRAS Wild-type Metastatic Colorectal Cancer With Acquired Resistance to EGFR Inhibitors and Emergence of MET Overexpression: Lesson Learned for Future Trials With EGFR/MET Dual Inhibition.
来源期刊：Clinical colorectal cancerDOI：10.1016/j.clcc.2019.02.004
Prognostic Effect of Tumor Sidedness in Colorectal Cancer: A SEER‐Based Analysis
来源期刊：Clinical Colorectal CancerDOI：10.1016/j.clcc.2018.10.005
Regorafenib Is Associated With Increased Skeletal Muscle Loss Compared to TAS-102 in Metastatic Colorectal Cancer.
来源期刊：Clinical colorectal cancerDOI：10.1016/J.CLCC.2019.04.003
Fluoropyrimidine Cardiotoxicity: Time for a Contemporaneous Appraisal
来源期刊：Clinical Colorectal CancerDOI：10.1016/j.clcc.2018.08.001
E‐Cadherin in Colorectal Cancer: Relation to Chemosensitivity
来源期刊：Clinical Colorectal CancerDOI：10.1016/j.clcc.2018.10.003
The Role of the Gut Microbiome in Colorectal Cancer: Where Are We? Where Are We Going?
来源期刊：Clinical colorectal cancerDOI：10.1016/J.CLCC.2019.07.006
Biologics, Immunotherapy, and Future Directions in the Treatment of Advanced Cholangiocarcinoma.
来源期刊：Clinical colorectal cancerDOI：10.1016/j.clcc.2019.02.005
Rising Incidence and Improved Survival of Anal Squamous Cell Carcinoma in Norway, 1987‐2016
来源期刊：Clinical Colorectal CancerDOI：10.1016/j.clcc.2018.10.001
Trends in Colorectal Cancer Incidence and Survival in Iowa SEER Data: The Timing of It All.
来源期刊：Clinical colorectal cancerDOI：10.1016/j.clcc.2018.12.001
Effects of Adjuvant Chemotherapy on Cognitive Function of Patients With Early‐stage Colorectal Cancer
来源期刊：Clinical Colorectal CancerDOI：10.1016/j.clcc.2018.09.002
Disqualification of Neoadjuvant Rectal Score Based on Data of 6596 Patients From the Netherlands Cancer Registry.
来源期刊：Clinical colorectal cancerDOI：10.1016/j.clcc.2019.01.001
Tumor-associated Macrophages and Neuroendocrine Differentiation Decrease the Efficacy of Bevacizumab Plus Chemotherapy in Patients With Advanced Colorectal Cancer.
来源期刊：Clinical colorectal cancerDOI：10.1016/j.clcc.2018.12.004
Angiogenic and Antiangiogenic VEGFA Splice Variants in Colorectal Cancer: Prospective Retrospective Cohort Study in Patients Treated With Irinotecan-Based Chemotherapy and Bevacizumab.
来源期刊：Clinical colorectal cancerDOI：10.1016/J.CLCC.2019.07.007
A Pilot Study of the PD-1 Targeting Agent AMP-224 Used With Low-Dose Cyclophosphamide and Stereotactic Body Radiation Therapy in Patients With Metastatic Colorectal Cancer.
来源期刊：Clinical colorectal cancerDOI：10.1016/J.CLCC.2019.06.004
KRAS Status as a Predictor of Chemotherapy Activity in Patients With Metastatic Colorectal Cancer.
来源期刊：Clinical colorectal cancerDOI：10.1016/j.clcc.2019.05.004
Efficacy and Safety of Aflibercept in Combination With Chemotherapy Beyond Second-Line Therapy in Metastatic Colorectal Carcinoma Patients: An AGEO Multicenter Study.
来源期刊：Clinical colorectal cancerDOI：10.1016/j.clcc.2019.08.003
Validated Nomogram Predicting 6-Month Survival in Pancreatic Cancer Patients Receiving First-Line 5-Fluorouracil, Oxaliplatin, and Irinotecan.
来源期刊：Clinical colorectal cancerDOI：10.1016/j.clcc.2019.08.004
Rationale and Design of the IROCAS Study: Multicenter, International, Randomized Phase 3 Trial Comparing Adjuvant Modified (m) FOLFIRINOX to mFOLFOX6 in Patients With High‐Risk Stage III (pT4 and/or N2) Colon Cancer—A UNICANCER GI‐PRODIGE Trial
来源期刊：Clinical Colorectal CancerDOI：10.1016/j.clcc.2018.09.011
Diagnostic Nodes of Patient Selection for Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy Among Colorectal Cancer Patients: A Swiss National Multicenter Survey.
来源期刊：Clinical colorectal cancerDOI：10.1016/J.CLCC.2019.06.002
ACORN: Observational Study of Bevacizumab in Combination With First-Line Chemotherapy for Treatment of Metastatic Colorectal Cancer in the UK.
来源期刊：Clinical colorectal cancerDOI：10.1016/J.CLCC.2019.07.003
FOLFCIS Treatment and Genomic Correlates of Response in Advanced Anal Squamous Cell Cancer
来源期刊：Clinical Colorectal CancerDOI：10.1016/j.clcc.2018.09.005
What is the Optimal Preoperative Imaging Modality for Assessing Peritoneal Cancer Index? An Analysis From the United States HIPEC Collaborative.
来源期刊：Clinical colorectal cancerDOI：10.1016/j.clcc.2019.12.002
Safety and Oncological Outcomes of Bevacizumab Therapy in Patients With Advanced Colorectal Cancer and Self-expandable Metal Stents.
来源期刊：Clinical colorectal cancerDOI：10.1016/j.clcc.2019.05.009
Metronomic Capecitabine With Cyclophosphamide Regimen in Unresectable or Relapsed Pseudomyxoma Peritonei.
来源期刊：Clinical colorectal cancerDOI：10.1016/J.CLCC.2019.03.002
Neoadjuvant Chemotherapy With mFOLFOXIRI Without Routine Use of Radiotherapy for Locally Advanced Rectal Cancer.
来源期刊：Clinical colorectal cancerDOI：10.1016/j.clcc.2019.07.001
Prognostic Effect of Adenosine‐related Genetic Variants in Metastatic Colorectal Cancer Treated With Bevacizumab‐based Chemotherapy
来源期刊：Clinical Colorectal CancerDOI：10.1016/j.clcc.2018.09.003
Overuse and Limited Benefit of Chemotherapy for Stage II Colon Cancer in Young Patients.
来源期刊：Clinical colorectal cancerDOI：10.1016/J.CLCC.2019.04.002
Novel Prognostic Factors in Resected Small Bowel Adenocarcinoma.
来源期刊：Clinical colorectal cancerDOI：10.1016/J.CLCC.2019.05.002
Network Mapping of Molecular Biomarkers Influencing Radiation Response in Rectal Cancer.
来源期刊：Clinical colorectal cancerDOI：10.1016/J.CLCC.2019.01.004
Efficacy and Safety of Two Neoadjuvant Strategies With Bevacizumab in MRI-Defined Locally Advanced T3 Resectable Rectal Cancer: Final Results of a Randomized, Noncomparative Phase 2 INOVA Study.
来源期刊：Clinical colorectal cancerDOI：10.1016/J.CLCC.2019.04.006
Survival Outcomes After Surgical Management of the Primary Tumor With and Without Radiotherapy for Metastatic Rectal Adenocarcinoma: A National Cancer Database (NCDB) Analysis.
来源期刊：Clinical colorectal cancerDOI：10.1016/j.clcc.2018.12.005
Impact of Single-organ Metastasis to the Liver or Lung and Genetic Mutation Status on Prognosis in Stage IV Colorectal Cancer.
来源期刊：Clinical colorectal cancerDOI：10.1016/j.clcc.2019.12.001
ACTH‐Secreting Neuroendocrine Carcinoma of the Cecum: Case Report and Review of the Literature
来源期刊：Clinical Colorectal CancerDOI：10.1016/j.clcc.2018.07.013
Efficacy and Cardiotoxic Safety Profile of Raltitrexed in Fluoropyrimidines‐Pretreated or High‐Risk Cardiac Patients With GI Malignancies: Large Single‐Center Experience
来源期刊：Clinical Colorectal CancerDOI：10.1016/j.clcc.2018.09.010
Effect of Responsiveness of Lymph Nodes to Preoperative Chemoradiotherapy in Patients With Rectal Cancer on Prognosis After Radical Resection.
来源期刊：Clinical colorectal cancerDOI：10.1016/j.clcc.2019.03.001
Colon Cancer Tumor Location Defined by Gene Expression May Disagree With Anatomic Tumor Location.
来源期刊：Clinical colorectal cancerDOI：10.1016/j.clcc.2019.02.002
Type and Consequences of Short-Term Complications in Colon Cancer Surgery, Focusing on the Oldest Old.
来源期刊：Clinical colorectal cancerDOI：10.1016/j.clcc.2019.11.003
Anti-Mesothelin Recombinant Immunotoxin Therapy for Colorectal Cancer.
来源期刊：Clinical colorectal cancerDOI：10.1016/J.CLCC.2019.06.006
Lung Metastasis Predicts Better Prognosis in Metastatic Colorectal Cancer With Mutated KRAS.
来源期刊：Clinical colorectal cancerDOI：10.1016/j.clcc.2019.06.001
Relationship Between Tumor Response and Tumor-Related Symptoms in RAS Wild-Type Metastatic Colorectal Cancer: Retrospective Analyses From 3 Panitumumab Trials.
来源期刊：Clinical colorectal cancerDOI：10.1016/J.CLCC.2019.07.009
Health-related Quality of Life in the Phase III LUME-Colon 1 Study: Comparison and Interpretation of Results From EORTC QLQ-C30 Analyses.
来源期刊：Clinical colorectal cancerDOI：10.1016/j.clcc.2019.08.005
Patient-reported Symptom Outcomes and Microsatellite Instability in Patients With Metastatic Colorectal Cancer.
来源期刊：Clinical colorectal cancerDOI：10.1016/j.clcc.2019.10.006
Pathologic Staging Inconsistency Between ypT4N0 (stage II) and ypT1‐2N1 (stage III) After Preoperative Chemoradiotherapy and Total Mesorectal Excision in Rectal Cancer: A Multi‐Institutional Study
来源期刊：Clinical Colorectal CancerDOI：10.1016/j.clcc.2018.11.003
