Clinical Cancer Research publishes innovative clinical and translational cancer research studies that bridge the laboratory and the clinic. The Journal is especially interested in clinical trials evaluating new treatments, accompanied by research on pharmacology, and molecular alterations or biomarkers that predict response or resistance to treatment. The Journal also prioritizes laboratory and animal studies of new drugs and molecule-targeted agents with the potential to lead to clinical trials, and studies of targetable mechanisms of oncogenesis, progression of the malignant phenotype, and metastatic disease.Specific areas of interest include clinical and translational research in targeted therapies; mechanisms of drug sensitivity and resistance; pharmacogenetics and pharmacogenomics; personalized medicine; novel applications of bioinformatics and biostatistics; immunotherapy and clinical immunology; gene therapy; radiobiology and radiation oncology; large-scale molecular characterization of human tumors; diagnostic biomarkers; innovative imaging and other novel methods with potential applicability to clinical investigation; clinical genetics; and detection of minimal disease.
临床癌症研究出版创新的临床和转化癌症研究的研究，桥梁实验室和临床。该杂志对评估新疗法的临床试验特别感兴趣，同时对药理学、预测治疗反应或耐药性的分子变化或生物标志物进行研究。该杂志还优先考虑新药和分子靶向制剂的实验室和动物研究，有可能导致临床试验，以及肿瘤发生、恶性表型进展和转移性疾病的靶向机制研究。药物敏感和耐药机制;药物遗传学和药物基因组学;个性化医疗;生物信息学和生物统计学的新应用;免疫治疗和临床免疫学;基因治疗;放射生物学和放射肿瘤学;人类肿瘤的大规模分子表征;诊断性生物标志物;具有潜在临床研究适用性的创新成像和其他新方法;临床遗传学;和微小疾病检测。
Prognostic Value of Deep Learning PET/CT-Based Radiomics: Potential Role for Future Individual Induction Chemotherapy in Advanced Nasopharyngeal Carcinoma
来源期刊：Clinical Cancer ResearchDOI：10.1158/1078-0432.CCR-18-3065
The Immunoscore: Colon Cancer and Beyond
来源期刊：Clinical Cancer ResearchDOI：10.1158/1078-0432.CCR-18-1851
Association of Systemic Inflammation Index and Body Mass Index with Survival in Patients with Renal Cell Cancer Treated with Nivolumab
来源期刊：Clinical Cancer ResearchDOI：10.1158/1078-0432.CCR-18-3661
Nivolumab in Patients with Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck: Efficacy and Safety in CheckMate 141 by Prior Cetuximab Use
来源期刊：Clinical Cancer ResearchDOI：10.1158/1078-0432.CCR-18-3944
Potent Cell-Cycle Inhibition and Upregulation of Immune Response with Abemaciclib and Anastrozole in neoMONARCH, Phase II Neoadjuvant Study in HR+/HER2− Breast Cancer
来源期刊：Clinical Cancer ResearchDOI：10.1158/1078-0432.CCR-19-1425
Circulating Tumor DNA in HER2-Amplified Breast Cancer: A Translational Research Substudy of the NeoALTTO Phase III Trial
来源期刊：Clinical Cancer ResearchDOI：10.1158/1078-0432.CCR-18-2521
Role of KEAP1/NFE2L2 Mutations in the Chemotherapeutic Response of Patients with Non–Small Cell Lung Cancer
来源期刊：Clinical Cancer ResearchDOI：10.1158/1078-0432.CCR-19-1237
IL15 by Continuous Intravenous Infusion to Adult Patients with Solid Tumors in a Phase I Trial Induced Dramatic NK-Cell Subset Expansion
来源期刊：Clinical Cancer ResearchDOI：10.1158/1078-0432.CCR-18-3468
A Fatty Acid Oxidation-dependent Metabolic Shift Regulates the Adaptation of BRAF-mutated Melanoma to MAPK Inhibitors
来源期刊：Clinical Cancer ResearchDOI：10.1158/1078-0432.CCR-19-0253
Tumor Lysis, Adverse Events, and Dose Adjustments in 297 Venetoclax-Treated CLL Patients in Routine Clinical Practice
来源期刊：Clinical Cancer ResearchDOI：10.1158/1078-0432.CCR-19-0361
IL23-Producing Human Lung Cancer Cells Promote Tumor Growth via Conversion of Innate Lymphoid Cell 1 (ILC1) into ILC3
来源期刊：Clinical Cancer ResearchDOI：10.1158/1078-0432.CCR-18-3458
Proteomics-Derived Biomarker Panel Improves Diagnostic Precision to Classify Endometrioid and High-grade Serous Ovarian Carcinoma
来源期刊：Clinical Cancer ResearchDOI：10.1158/1078-0432.CCR-18-3818
Comprehensive Liquid Profiling of Circulating Tumor DNA and Protein Biomarkers in Long-Term Follow-Up Patients with Hepatocellular Carcinoma
来源期刊：Clinical Cancer ResearchDOI：10.1158/1078-0432.CCR-18-3477
Immune Suppression by PD-L2 against Spontaneous and Treatment-Related Antitumor Immunity
来源期刊：Clinical Cancer ResearchDOI：10.1158/1078-0432.CCR-18-3991
Trabectedin Inhibits EWS-FLI1 and Evicts SWI/SNF from Chromatin in a Schedule-dependent Manner
来源期刊：Clinical Cancer ResearchDOI：10.1158/1078-0432.CCR-18-3511
Efficacy and Safety of the Biosimilar ABP 215 Compared with Bevacizumab in Patients with Advanced Nonsquamous Non–small Cell Lung Cancer (MAPLE): A Randomized, Double-blind, Phase III Study
来源期刊：Clinical Cancer ResearchDOI：10.1158/1078-0432.CCR-18-2702
A Novel Mitochondrial Inhibitor Blocks MAPK Pathway and Overcomes MAPK Inhibitor Resistance in Melanoma
来源期刊：Clinical Cancer ResearchDOI：10.1158/1078-0432.CCR-19-0836
Validation of Melanoma Immune Profile (MIP), a Prognostic Immune Gene Prediction Score for Stage II–III Melanoma
来源期刊：Clinical Cancer ResearchDOI：10.1158/1078-0432.CCR-18-2847
Intratumoral Adaptive Immunosuppression and Type 17 Immunity in Mismatch Repair Proficient Colorectal Tumors
来源期刊：Clinical Cancer ResearchDOI：10.1158/1078-0432.CCR-19-0114
A Phase II Trial of Pembrolizumab and Vorinostat in Recurrent Metastatic Head and Neck Squamous Cell Carcinomas and Salivary Gland Cancer
来源期刊：Clinical Cancer ResearchDOI：10.1158/1078-0432.CCR-19-2214
TBCRC023: A Randomized Phase II Neoadjuvant Trial of Lapatinib Plus Trastuzumab Without Chemotherapy for 12 versus 24 Weeks in Patients with HER2-Positive Breast Cancer
来源期刊：Clinical Cancer ResearchDOI：10.1158/1078-0432.CCR-19-0851
HER2-Overexpressing/Amplified Breast Cancer as a Testing Ground for Antibody–Drug Conjugate Drug Development in Solid Tumors
来源期刊：Clinical Cancer ResearchDOI：10.1158/1078-0432.CCR-18-1976
A First-in-Human Phase I Study of INVAC-1, an Optimized Human Telomerase DNA Vaccine in Patients with Advanced Solid Tumors
来源期刊：Clinical Cancer ResearchDOI：10.1158/1078-0432.CCR-19-1614
Therapeutic Targeting of TGFβ Ligands in Glioblastoma Using Novel Antisense Oligonucleotides Reduces the Growth of Experimental Gliomas
来源期刊：Clinical Cancer ResearchDOI：10.1158/1078-0432.CCR-17-3024
Cell-Proliferation Imaging for Monitoring Response to CDK4/6 Inhibition Combined with Endocrine-Therapy in Breast Cancer: Comparison of [18F]FLT and [18F]ISO-1 PET/CT
来源期刊：Clinical Cancer ResearchDOI：10.1158/1078-0432.CCR-18-2769
Phase I Study of a CD45-Targeted Antibody–Radionuclide Conjugate for High-Risk Lymphoma
来源期刊：Clinical Cancer ResearchDOI：10.1158/1078-0432.CCR-19-1567
Harmonic Motion Imaging of Pancreatic Tumor Stiffness Indicates Disease State and Treatment Response
来源期刊：Clinical Cancer ResearchDOI：10.1158/1078-0432.CCR-18-3669
An Integrative Approach to Inform Optimal Administration of OX40 Agonist Antibodies in Patients with Advanced Solid Tumors
来源期刊：Clinical Cancer ResearchDOI：10.1158/1078-0432.CCR-19-0526
Phase I Clinical Trial of the Wee1 Inhibitor Adavosertib (AZD1775) with Irinotecan in Children with Relapsed Solid Tumors: A COG Phase I Consortium Report (ADVL1312)
来源期刊：Clinical Cancer ResearchDOI：10.1158/1078-0432.CCR-19-3470
Molecular Characterization of Locally Relapsed Head and Neck Cancer after Concomitant Chemoradiotherapy
来源期刊：Clinical Cancer ResearchDOI：10.1158/1078-0432.CCR-19-0628
DNA Methylation Profiling Identifies Distinct Clusters in Angiosarcomas
来源期刊：Clinical Cancer ResearchDOI：10.1158/1078-0432.CCR-19-2180
FDA Approval Summary: Calaspargase Pegol-mknl For Treatment of Acute Lymphoblastic Leukemia in Children and Young Adults
来源期刊：Clinical Cancer ResearchDOI：10.1158/1078-0432.CCR-19-1255
Oncogenic NRG1 Fusions: A New Hope for Targeted Therapy in Pancreatic Cancer
来源期刊：Clinical Cancer ResearchDOI：10.1158/1078-0432.CCR-19-1280
Multicenter, Open-Label, Phase II Study of Bendamustine and Rituximab Followed by 90-Yttrium (Y) Ibritumomab Tiuxetan for Untreated Follicular Lymphoma (Fol-BRITe)
来源期刊：Clinical Cancer ResearchDOI：10.1158/1078-0432.CCR-18-3755
A PI3K/AKT Scaffolding Protein, IQ Motif–Containing GTPase Associating Protein 1 (IQGAP1), Promotes Head and Neck Carcinogenesis
来源期刊：Clinical Cancer ResearchDOI：10.1158/1078-0432.CCR-19-1063
Cytotoxic T Cells and their Activation Status are Independent Prognostic Markers in Meningiomas
来源期刊：Clinical Cancer ResearchDOI：10.1158/1078-0432.CCR-19-0389
Molecular and Clinical Activity of CDX-3379, an Anti-ErbB3 Monoclonal Antibody, in Head and Neck Squamous Cell Carcinoma Patients
来源期刊：Clinical Cancer ResearchDOI：10.1158/1078-0432.CCR-18-3453
Linsitinib (OSI-906) for the Treatment of Adult and Pediatric Wild-Type Gastrointestinal Stromal Tumors, a SARC Phase II Study
来源期刊：Clinical Cancer ResearchDOI：10.1158/1078-0432.CCR-19-1069
BRAF Inhibition: Bridge or Boost to T-cell Therapy?
来源期刊：Clinical Cancer ResearchDOI：10.1158/1078-0432.CCR-19-0286
Pembrolizumab Exposure–Response Assessments Challenged by Association of Cancer Cachexia and Catabolic Clearance—Letter
来源期刊：Clinical Cancer ResearchDOI：10.1158/1078-0432.CCR-19-0164
MAP9 Loss Triggers Chromosomal Instability, Initiates Colorectal Tumorigenesis, and Is Associated with Poor Survival of Patients with Colorectal Cancer
来源期刊：Clinical Cancer ResearchDOI：10.1158/1078-0432.CCR-19-1611
Comprehensive Transcriptome Profiling of Cryptic CBFA2T3–GLIS2 Fusion–Positive AML Defines Novel Therapeutic Options: A COG and TARGET Pediatric AML Study
来源期刊：Clinical Cancer ResearchDOI：10.1158/1078-0432.CCR-19-1800
Tisotumab Vedotin in Previously Treated Recurrent or Metastatic Cervical Cancer
来源期刊：Clinical Cancer ResearchDOI：10.1158/1078-0432.CCR-19-2962
Mogamulizumab Forecast: Clearer Patients, with a Slight Chance of Immune Mayhem
来源期刊：Clinical Cancer ResearchDOI：10.1158/1078-0432.CCR-19-2742
Abstract AP16: MODELING ENDOMETRIOID AND HIGH GRADE SEROUS CARCINOMAS IN THE MOUSE USING CRISPR/CAS9-MEDIATED SOMATIC GENE EDITING IN FALLOPIAN TUBE EPITHELIUM
来源期刊：Clinical Cancer ResearchDOI：10.1158/1557-3265.OVCASYMP18-AP16
Abstract GMM-041: OVARIAN CANCER CELLS INDUCE A FEEDBACK RESPONSE TO PLATINUM-BASED CHEMOTHERAPY BY ACTIVATING AN ONCOGENIC RSK-EPHA2-GPRC5A SIGNALING SWITCH
来源期刊：Clinical Cancer ResearchDOI：10.1158/1557-3265.OVCASYMP18-GMM-041
AACR Cancer Progress Report 2019: Transforming Lives Through Innovative Cancer Science
来源期刊：Clinical Cancer ResearchDOI：10.1158/1078-0432.ccr-19-2655
Abstract DP-013: DEVELOPMENT AND VALIDATION OF CIRCULATING CA125 PREDICTION MODEL IN POSTMENOPAUSAL WOMEN WITHOUT OVARIAN CANCER
来源期刊：Clinical Cancer ResearchDOI：10.1158/1557-3265.OVCASYMP18-DP-013
Quantitative Ultrasound Spectroscopy for Differentiation of Hepatocellular Carcinoma from At-Risk and Normal Liver Parenchyma
来源期刊：Clinical Cancer ResearchDOI：10.1158/1078-0432.CCR-19-1030
A Solution to the Dilution: The Role for Biomarkers in Advanced Ovarian Cancer
来源期刊：Clinical Cancer ResearchDOI：10.1158/1078-0432.CCR-19-3072
