Clinical and Experimental Pharmacology and Physiology is an international journal founded in 1974 by Mike Rand, Austin Doyle, John Coghlan and Paul Korner. Our focus is new frontiers in physiology and pharmacology, emphasizing the translation of basic research to clinical practice. We publish original articles, invited reviews and our exciting, cutting-edge Frontiers-in-Research series’.
《临床与实验药理学与生理学》（Clinical and Experimental Pharmacology and Physiology）是一本国际性期刊，由迈克·兰德（Mike Rand）、奥斯汀·道尔（Austin Doyle）、约翰·科格兰（John Coghlan）和保罗·科纳（Paul Korner）于1974年创办。我们的重点是生理学和药理学的新前沿，强调将基础研究转化为临床实践。我们发表原创文章，邀请评论和我们令人兴奋的，尖端的前沿研究系列。
A systematic review of the effects of oleoylethanolamide, a high‐affinity endogenous ligand of PPAR‐α, on the management and prevention of obesity
来源期刊：Clinical and Experimental Pharmacology and PhysiologyDOI：10.1111/1440-1681.13238
Omega‐3 fatty acids in coronary heart disease: Recent updates and future perspectives
来源期刊：Clinical and Experimental Pharmacology and PhysiologyDOI：10.1111/1440-1681.13034
Update on pathophysiology and preventive strategies of anthracycline‐induced cardiotoxicity
来源期刊：Clinical and Experimental Pharmacology and PhysiologyDOI：10.1111/1440-1681.13036
P2X7 receptor in cardiovascular disease: The heart side.
来源期刊：Clinical and Experimental Pharmacology and PhysiologyDOI：10.1111/1440-1681.13079
The GnRH analogues affect novel neuropeptide SMIM20/phoenixin and GPR173 receptor expressions in the female rat hypothalamic–pituitary–gonadal (HPG) axis
来源期刊：Clinical and Experimental Pharmacology and PhysiologyDOI：10.1111/1440-1681.13061
Metformin alleviates renal injury in diabetic rats by inducing Sirt1/FoxO1 autophagic signal axis
来源期刊：Clinical and Experimental Pharmacology and PhysiologyDOI：10.1111/1440-1681.13226
Platycodin D inhibits proliferation, migration and induces chemosensitization through inactivation of the NF‐κB and JAK2/STAT3 pathways in multiple myeloma cells
来源期刊：Clinical and Experimental Pharmacology and PhysiologyDOI：10.1111/1440-1681.13145
SPNS2 promotes the malignancy of colorectal cancer cells via regulating Akt and ERK pathway
来源期刊：Clinical and Experimental Pharmacology and PhysiologyDOI：10.1111/1440-1681.13124
Bradykinin‐potentiating factor isolated from Leiurus quinquestriatus scorpion venom alleviates cardiomyopathy in irradiated rats via remodelling of the RAAS pathway
来源期刊：Clinical and Experimental Pharmacology and PhysiologyDOI：10.1111/1440-1681.13202
Glutathione peroxidase‐1 gene rescues cocaine‐induced conditioned place preference in mice by inhibiting σ‐1 receptor expression
来源期刊：Clinical and Experimental Pharmacology and PhysiologyDOI：10.1111/1440-1681.13140
Upregulation of C/EBPβ and TSC2 by an HDAC inhibitor CG200745 protects heart from DOCA‐induced hypertrophy
来源期刊：Clinical and Experimental Pharmacology and PhysiologyDOI：10.1111/1440-1681.13022
Potential roles of Citrulline and watermelon extract on metabolic and inflammatory variables in diabetes mellitus, current evidence and future directions: A systematic review
来源期刊：Clinical and Experimental Pharmacology and PhysiologyDOI：10.1111/1440-1681.13190
Consumption of a high‐fat diet does not potentiate the deleterious effects on lipid and protein levels and body development in rats subjected to maternal protein restriction
来源期刊：Clinical and Experimental Pharmacology and PhysiologyDOI：10.1111/1440-1681.13210
Insulin‐like growth factor binding protein 7 accelerates hepatic steatosis and insulin resistance in non‐alcoholic fatty liver disease
来源期刊：Clinical and Experimental Pharmacology and PhysiologyDOI：10.1111/1440-1681.13159
Simultaneous angiotensin receptor blockade and glucagon‐like peptide‐1 receptor activation ameliorate albuminuria in obese insulin‐resistant rats
来源期刊：Clinical and Experimental Pharmacology and PhysiologyDOI：10.1111/1440-1681.13206
Effects of metoprolol, methyldopa, and nifedipine on endothelial progenitor cells in patients with gestational hypertension and preeclampsia
来源期刊：Clinical and Experimental Pharmacology and PhysiologyDOI：10.1111/1440-1681.13063
Th17 cells in glaucoma patients promote Ig production in IL‐17A and IL‐21‐dependent manner
来源期刊：Clinical and Experimental Pharmacology and PhysiologyDOI：10.1111/1440-1681.13141
Effect of imidazoline‐1 receptor agonists on renal dysfunction in rats associated with chronic, sequential fructose and ethanol administration
来源期刊：Clinical and Experimental Pharmacology and PhysiologyDOI：10.1111/1440-1681.13232
Protective effects of diphenyleneiodonium, an NADPH oxidase inhibitor, on lipopolysaccharide‐induced acute lung injury
来源期刊：Clinical and Experimental Pharmacology and PhysiologyDOI：10.1111/1440-1681.13050
Effects of selective serotonin reuptake inhibitors on motility of isolated fallopian tube
来源期刊：Clinical and Experimental Pharmacology and PhysiologyDOI：10.1111/1440-1681.13118
Isoliquiritigenin‐induced vasodilation by activating large‐conductance Ca2+‐activated K+ channels in mouse mesenteric arteries
来源期刊：Clinical and Experimental Pharmacology and PhysiologyDOI：10.1111/1440-1681.13156
Neuropharmacological effects of Aconiti Lateralis Radix Praeparata
来源期刊：Clinical and Experimental Pharmacology and PhysiologyDOI：10.1111/1440-1681.13228
Hypoperfusion in the posterior cingulate cortex is associated with lower bone mass density in elderly women with osteopenia and Alzheimer’s disease
来源期刊：Clinical and Experimental Pharmacology and PhysiologyDOI：10.1111/1440-1681.13217
Diminazene aceturate (DIZE) has cellular and in vivo antiarrhythmic effects
来源期刊：Clinical and Experimental Pharmacology and PhysiologyDOI：10.1111/1440-1681.13200
Pharmacogenomics guidelines: Current status and future development
来源期刊：Clinical and Experimental Pharmacology and PhysiologyDOI：10.1111/1440-1681.13097
Morin attenuates oxidized low‐density lipoprotein‐mediated injury by inducing autophagy via activating AMPK signalling in HUVECs
来源期刊：Clinical and Experimental Pharmacology and PhysiologyDOI：10.1111/1440-1681.13160
Silencing of C3G increases cardiomyocyte survival inhibition and apoptosis via regulation of p‐ERK1/2 and Bax
来源期刊：Clinical and Experimental Pharmacology and PhysiologyDOI：10.1111/1440-1681.13027
The anticholinergic drug oxybutynin inhibits voltage‐dependent K+ channels in coronary arterial smooth muscle cells
来源期刊：Clinical and Experimental Pharmacology and PhysiologyDOI：10.1111/1440-1681.13138
Metabolic‐vascular coupling in skeletal muscle: A potential role for capillary pericytes?
来源期刊：Clinical and Experimental Pharmacology and PhysiologyDOI：10.1111/1440-1681.13208
The vascular endothelium plays a role in insulin action
来源期刊：Clinical and Experimental Pharmacology and PhysiologyDOI：10.1111/1440-1681.13171
A prospective, randomized trial of intravenous hydroxocobalamin versus noradrenaline or saline for treatment of lipopolysaccharide‐induced hypotension in a swine model
来源期刊：Clinical and Experimental Pharmacology and PhysiologyDOI：10.1111/1440-1681.13060
Non‐invasive three‐dimensional power Doppler imaging for the assessment of acute cerebral blood flow alteration in a mouse model of subarachnoid haemorrhage
来源期刊：Clinical and Experimental Pharmacology and PhysiologyDOI：10.1111/1440-1681.13035
Effects of ANP on pulmonary vein electrophysiology, Ca2+ homeostasis and adrenergic arrhythmogenesis via PKA
来源期刊：Clinical and Experimental Pharmacology and PhysiologyDOI：10.1111/1440-1681.13199
Issue Information
来源期刊：Clinical and Experimental Pharmacology and PhysiologyDOI：10.1111/1440-1681.12989
Glycyrrhizin treatment ameliorates post‐traumatic stress disorder‐like behaviours and restores circadian oscillation of intracranial serotonin
来源期刊：Clinical and Experimental Pharmacology and PhysiologyDOI：10.1111/1440-1681.13173
A directly GP130‐targeting small molecule ameliorates collagen‐induced arthritis (CIA) by inhibiting IL‐6/GP130 signalling and Th17 differentiation
来源期刊：Clinical and Experimental Pharmacology and PhysiologyDOI：10.1111/1440-1681.13215
Pharmacokinetics, tissue distribution, plasma protein binding, and metabolism study of mefunidone, a novel pirfenidone derivative
来源期刊：Clinical and Experimental Pharmacology and PhysiologyDOI：10.1111/1440-1681.13078
Biophysical and biological characterization of PEGylated recombinant human endostatin
来源期刊：Clinical and Experimental Pharmacology and PhysiologyDOI：10.1111/1440-1681.13134
Issue Information
来源期刊：Clinical and Experimental Pharmacology and PhysiologyDOI：10.1111/1440-1681.12988
Involvement of miR‐200b–PKCα signalling in pulmonary hypertension in cor pulmonale model
来源期刊：Clinical and Experimental Pharmacology and PhysiologyDOI：10.1111/1440-1681.13213
Breast cancer drugs perturb fundamental vascular functions of endothelial cells by attenuating protein S‐nitrosylation
来源期刊：Clinical and Experimental Pharmacology and PhysiologyDOI：10.1111/1440-1681.13181
Knockdown of TMEM45A overcomes multidrug resistance and epithelial–mesenchymal transition in human colorectal cancer cells through inhibition of TGF‐β signalling pathway
来源期刊：Clinical and Experimental Pharmacology and PhysiologyDOI：10.1111/1440-1681.13220
Issue Information
来源期刊：Clinical and Experimental Pharmacology and PhysiologyDOI：10.1111/1440-1681.12990
Successful intravenous Alteplase for a centenarian woman with acute ischaemic stroke
来源期刊：Clinical and Experimental Pharmacology and PhysiologyDOI：10.1111/1440-1681.13067
Pyrroloquinoline quinone delays inflammaging induced by TNF‐α through the p16/p21 and Jagged1 signalling pathways
来源期刊：Clinical and Experimental Pharmacology and PhysiologyDOI：10.1111/1440-1681.13176
Issue Information
来源期刊：Clinical and Experimental Pharmacology and PhysiologyDOI：10.1111/1440-1681.12981
Association of endogenous DHEA/DHEAS with coronary heart disease: A systematic review and meta‐analysis
来源期刊：Clinical and Experimental Pharmacology and PhysiologyDOI：10.1111/1440-1681.13146
Functional activation of Gαq/11 protein via α1‐adrenoceptor in rat cerebral cortical membranes
来源期刊：Clinical and Experimental Pharmacology and PhysiologyDOI：10.1111/1440-1681.13084
Effects of nitric oxide on apoptosis and voltage‐gated calcium channels in human cardiac myofibroblasts
来源期刊：Clinical and Experimental Pharmacology and PhysiologyDOI：10.1111/1440-1681.13178
Withdrawn: Associations of candidate gene polymorphisms with poor responsiveness to aspirin: A meta‐analysis. Shen Jiang, Ying Yue, Chaolun Gou, Shan Hu and Yanhua Tang
来源期刊：Clinical and Experimental Pharmacology and PhysiologyDOI：10.1111/1440-1681.12973
