Clinical and Experimental Medicine (CEM) is a multidisciplinary journal that aims to be a forum of scientific excellence and information exchange in relation to the basic and clinical features of the following fields: hematology, onco-hematology, oncology, virology, immunology, and rheumatology. The journal publishes reviews and editorials, experimental and preclinical studies, translational research, prospectively designed clinical trials, and epidemiological studies. Papers containing new clinical or experimental data that are likely to contribute to changes in clinical practice or the way in which a disease is thought about will be given priority due to their immediate importance. Case reports will be accepted on an exceptional basis only, and their submission is discouraged. The major criteria for publication are clarity, scientific soundness, and advances in knowledge. In compliance with the overwhelmingly prevailing request by the international scientific community, and with respect for eco-compatibility issues, CEM is now published exclusively online.
临床和实验医学（CEM）是一个多学科期刊，旨在成为以下领域的基本和临床特征相关的科学卓越性和信息交流的论坛：血液学、肿瘤血液学、肿瘤学、病毒学、免疫学和风湿病学。该杂志发表评论和社论、实验和临床前研究、转化研究、前瞻性设计的临床试验和流行病学研究。包含新的临床或实验数据的论文，可能有助于改变临床实践或疾病的思考方式，由于其直接的重要性，将被优先考虑。仅在例外情况下接受病例报告，不鼓励提交。出版的主要标准是清晰度、科学合理性和知识的进步。根据国际科学界压倒性的普遍要求，并考虑到生态相容性问题，CEM现在只在网上发表。
Serum miR-122 levels correlate with diabetic retinopathy
来源期刊：Clinical and Experimental MedicineDOI：10.1007/s10238-019-00546-x
Eculizumab in refractory catastrophic antiphospholipid syndrome: a case report and systematic review of the literature
来源期刊：Clinical and Experimental MedicineDOI：10.1007/s10238-019-00565-8
NK and NKT-like cells in granulomatous and fibrotic lung diseases
来源期刊：Clinical and Experimental MedicineDOI：10.1007/s10238-019-00578-3
Direct antiviral agents upregulate natural killer cell potential activity in chronic hepatitis C patients
来源期刊：Clinical and Experimental MedicineDOI：10.1007/s10238-019-00564-9
The value of four imaging modalities in diagnosing lymph node involvement in rectal cancer: an overview and adjusted indirect comparison
来源期刊：Clinical and Experimental MedicineDOI：10.1007/s10238-019-00552-z
Mutation analysis of POLE gene in patients with early-onset colorectal cancer revealed a rare silent variant within the endonuclease domain with potential effect on splicing
来源期刊：Clinical and Experimental MedicineDOI：10.1007/s10238-019-00558-7
Advances in liquid biopsy using circulating tumor cells and circulating cell-free tumor DNA for detection and monitoring of breast cancer
来源期刊：Clinical and Experimental MedicineDOI：10.1007/s10238-019-00563-w
Droplet digital PCR revealed high concordance between primary tumors and lymph node metastases in multiplex screening of KRAS mutations in colorectal cancer
来源期刊：Clinical and Experimental MedicineDOI：10.1007/s10238-019-00545-y
Circulating soluble levels of MIF in women with breast cancer in the molecular subtypes: relationship with Th17 cytokine profile
来源期刊：Clinical and Experimental MedicineDOI：10.1007/s10238-019-00559-6
Serum lipidome screening in patients with stage I non-small cell lung cancer
来源期刊：Clinical and Experimental MedicineDOI：10.1007/s10238-019-00566-7
B7-H4 facilitates proliferation and metastasis of colorectal carcinoma cell through PI3K/Akt/mTOR signaling pathway
来源期刊：Clinical and Experimental MedicineDOI：10.1007/s10238-019-00590-7
Adeno-associated virus as a gene therapy vector: strategies to neutralize the neutralizing antibodies
来源期刊：Clinical and Experimental MedicineDOI：10.1007/s10238-019-00557-8
Comparison between clinical significance of serum CXCL-8 and classical tumor markers in oesophageal cancer (OC) patients
来源期刊：Clinical and Experimental MedicineDOI：10.1007/s10238-019-00548-9
High BAFF expression associated with active disease in systemic lupus erythematosus and relationship with rs9514828C>T polymorphism in TNFSF13B gene
来源期刊：Clinical and Experimental MedicineDOI：10.1007/s10238-019-00549-8
Early echocardiographic detection of left ventricular diastolic dysfunction in patients with systemic lupus erythematosus asymptomatic for cardiovascular disease
来源期刊：Clinical and Experimental MedicineDOI：10.1007/s10238-019-00600-8
The association between matrix metalloproteinase-7 genetic variant and bladder cancer risk in a Chinese Han population
来源期刊：Clinical and Experimental MedicineDOI：10.1007/s10238-019-00582-7
Radiation-induced lung injury: latest molecular developments, therapeutic approaches, and clinical guidance
来源期刊：Clinical and Experimental MedicineDOI：10.1007/s10238-019-00571-w
Cell adhesion molecules, plasminogen activator inhibitor type 1, and metabolic syndrome in patients with psoriasis
来源期刊：Clinical and Experimental MedicineDOI：10.1007/s10238-019-00595-2
Neutrocyte-to-lymphocyte ratio predicts the presence of a replicative hepatitis C virus strand after therapy with direct-acting antivirals
来源期刊：Clinical and Experimental MedicineDOI：10.1007/s10238-019-00561-y
FGB and FGG derived from plasma exosomes as potential biomarkers to distinguish benign from malignant pulmonary nodules
来源期刊：Clinical and Experimental MedicineDOI：10.1007/s10238-019-00581-8
Changes in APRI and FIB-4 in HBeAg-negative treatment-naive chronic hepatitis B patients with significant liver histological lesions receiving 5-year entecavir therapy
来源期刊：Clinical and Experimental MedicineDOI：10.1007/s10238-019-00560-z
MicroRNA-423 may regulate diabetic vasculopathy
来源期刊：Clinical and Experimental MedicineDOI：10.1007/s10238-019-00573-8
Anti-domain 1 of beta2-glycoprotein I aids risk stratification in lupus anticoagulant-positive patients
来源期刊：Clinical and Experimental MedicineDOI：10.1007/s10238-019-00555-w
Assessment of CD40 and CD40L expression in rheumatoid arthritis patients, association with clinical features and DAS28
来源期刊：Clinical and Experimental MedicineDOI：10.1007/s10238-019-00568-5
The clinicopathological and prognostic value of PD-L1 in urothelial carcinoma: a meta-analysis
来源期刊：Clinical and Experimental MedicineDOI：10.1007/s10238-019-00572-9
Crescent lesions are not a predictive factor in adult-onset Henoch–Schönlein purpura nephritis
来源期刊：Clinical and Experimental MedicineDOI：10.1007/s10238-019-00567-6
Prevalence and characteristics of arthritis in Kawasaki disease: a Chinese cohort study
来源期刊：Clinical and Experimental MedicineDOI：10.1007/s10238-019-00547-w
MAT2B mediates invasion and metastasis by regulating EGFR signaling pathway in hepatocellular carcinoma
来源期刊：Clinical and Experimental MedicineDOI：10.1007/s10238-019-00579-2
Iron chelation therapy for myelodysplastic syndrome: a systematic review and meta-analysis
来源期刊：Clinical and Experimental MedicineDOI：10.1007/s10238-019-00592-5
Lag3+ regulatory T lymphocytes in critical carotid artery stenosis
来源期刊：Clinical and Experimental MedicineDOI：10.1007/s10238-019-00570-x
Clinical and pathological features of immunoglobulin A nephropathy patients with nephrotic syndrome
来源期刊：Clinical and Experimental MedicineDOI：10.1007/s10238-019-00580-9
Inhibition of HSP90 overcomes melphalan resistance through downregulation of Src in multiple myeloma cells
来源期刊：Clinical and Experimental MedicineDOI：10.1007/s10238-019-00587-2
Senescence-associated miR-34a and miR-126 in middle-aged Indians with type 2 diabetes
来源期刊：Clinical and Experimental MedicineDOI：10.1007/s10238-019-00593-4
Adenylate kinase 4 promotes bladder cancer cell proliferation and invasion
来源期刊：Clinical and Experimental MedicineDOI：10.1007/s10238-019-00576-5
Impact of estrogen receptor α on the tamoxifen response and prognosis in luminal-A-like and luminal-B-like breast cancer
来源期刊：Clinical and Experimental MedicineDOI：10.1007/s10238-019-00583-6
Microcystin-LR in peripheral circulation worsens the prognosis partly through oxidative stress in patients with hepatocellular carcinoma
来源期刊：Clinical and Experimental MedicineDOI：10.1007/s10238-019-00550-1
Genetic and epigenetic analysis of the beta-2-microglobulin gene in microsatellite instable colorectal cancer
来源期刊：Clinical and Experimental MedicineDOI：10.1007/s10238-019-00601-7
Severe thrombocytopenia in pregnancy: a case series from west China
来源期刊：Clinical and Experimental MedicineDOI：10.1007/s10238-019-00575-6
Correlation analysis of hepatitis C virus core antigen and low viral loads: Can core antigen replace nucleic acid test?
来源期刊：Clinical and Experimental MedicineDOI：10.1007/s10238-019-00588-1
TNFA -308G>A and -238G>A polymorphisms and risk to systemic sclerosis: impact on TNF-α serum levels, TNFA mRNA expression, and autoantibodies
来源期刊：Clinical and Experimental MedicineDOI：10.1007/s10238-019-00569-4
IL-8 gene locus is associated with risk, severity and 28-day mortality of sepsis in a Chinese population
来源期刊：Clinical and Experimental MedicineDOI：10.1007/s10238-019-00584-5
The role of fibroblast activation protein in progression and development of osteosarcoma cells
来源期刊：Clinical and Experimental MedicineDOI：10.1007/s10238-019-00591-6
Increased levels of circulating fibroblast growth factor 21 in children with Kawasaki disease
来源期刊：Clinical and Experimental MedicineDOI：10.1007/s10238-019-00577-4
PDCD1 and PDCD1LG1 polymorphisms affect the susceptibility to multiple myeloma
来源期刊：Clinical and Experimental MedicineDOI：10.1007/s10238-019-00585-4
Functional polymorphisms of the receptor for the advanced glycation end product promoter gene in inflammatory bowel disease: a case–control study
来源期刊：Clinical and Experimental MedicineDOI：10.1007/s10238-019-00562-x
Hepatic dysfunction secondary to Kawasaki disease: characteristics, etiology and predictive role in coronary artery abnormalities
来源期刊：Clinical and Experimental MedicineDOI：10.1007/s10238-019-00596-1
The epithelial cadherin –160C/A polymorphism is associated with decreased risk of colorectal cancer: a case–control study
来源期刊：Clinical and Experimental MedicineDOI：10.1007/s10238-019-00586-3
E3 ubiquitin ligase CHIP attenuates cellular proliferation and invasion abilities in triple-negative breast cancer cells
来源期刊：Clinical and Experimental MedicineDOI：10.1007/s10238-019-00594-3
Evaluation of the influence of social, demographic, environmental, work-related factors and/or lifestyle habits on Raynaud’s phenomenon: a case–control study
来源期刊：Clinical and Experimental MedicineDOI：10.1007/s10238-019-00589-0
TNF-β +252 A>G (rs909253) polymorphism is independently associated with presence of autoantibodies in rheumatoid arthritis patients\n
来源期刊：Clinical and Experimental MedicineDOI：10.1007/s10238-019-00556-9
